tHE ROLE OF corticotropin-RELEASING HORMONE IN INITIATION OF LABOR
https://doi.org/10.21886/2219-8075-2013-4-26-29
Abstract
Purpose: To determine the content of corticotropin-releasing hormone, substance P, prostaglandin F2a, neurokinins A and B, interleukins 6 and 8, relaxin and cortisol in the blood serum and amniotic fluid and to evaluate the influence of these markers on the biomechanism of labor.
Materials and methods: 100 parturient women were included in the study. Criteria for including in the group were the gestation term of 38 and more weeks and the absence of endocrine pathology. The blood serum and the amniotic fluid of the patients divided into 3 groups were studied by ELISA technique.
Results: In the course of study it was revealed that the rise in the concentration of corticotropin-releasing hormone, relaxin and cortisol in the blood serum together with low content of prostaglandin F2α increased the probability of labor anomaly development.
Summary: It should be noted that the course of labor and its outcome depend not only on the absolute values of biological substances in the studied media, but also on their interaction before and during labor.
About the Authors
T. G. Arutyunyan
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
V. A. Linde
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Zh. A. Elzhorukaeva
Rostov Scientific and Research Institute of Obstetrics and Pediatrics
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
Russian Federation
43, Mechnikova Str., Rostov-on-Don, 344012
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Review
For citations:
Arutyunyan T.G., Linde V.A., Elzhorukaeva Zh.A. tHE ROLE OF corticotropin-RELEASING HORMONE IN INITIATION OF LABOR. Medical Herald of the South of Russia. 2013;(4):26-29. (In Russ.) https://doi.org/10.21886/2219-8075-2013-4-26-29
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