Obesity = inflammation. Pathogenesis. How does this threaten men?
https://doi.org/10.21886/2219-8075-2020-11-4-6-23
Abstract
Today, adipose tissue has ceased to be perceived only as an energetic substance with its intrinsic properties in the form of thermoregulation and mechanical protection, known since the beginning of the twentieth century. Today, adipose tissue is a fullfledged endocrine organ that is distributed throughout the body — the usefulness of its work directly affects the energy balance, not only through involvement in the metabolism of carbohydrates and fats, but also by the production of many adipokines, a total of more than 600 known today. This review research the causal relationship of subclinical or systemic inflammation of adipose tissue with an excess of energy resources, insulin resistance, leptin, adiponectin, estrogen metabolites and one of the most pro-inflammatory cytokines - interleukin 6. Attention is also paid to the relationship between prostate cancer and obesity, as an ambiguous relationship due to the maximum paying attention to testosterone. Further study of adipose tissue will make it possible to establish specific pathophysiological mechanisms responsible for the development of not only disorders of carbohydrate metabolism, but also a number of other systems in view of the not fully understood systemic action of adipokines and associated inflammatory mediators in obese individuals. Systematic literature search was perform in the Medline, Scopus, Web of Science and elibrary databases.
About the Authors
Z. Sh. Pavlova
Medical Scientific-Educational Center of Lomonosov Moscow State University
Russian Federation
Russian Federation
Cand. Sci. (Med.), Endocrinologist, Senior Researcher, Department of Age-Associated Diseases,
Moscow
I. I. Golodnikov
https://istina.msu.ru/profile/Ivan.gol/
Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Medical Academy of Continuing Professional Education
Russian Federation
Resident Physician, Department of Endocrinology,
Moscow
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For citations:
Pavlova Z.Sh., Golodnikov I.I. Obesity = inflammation. Pathogenesis. How does this threaten men? Medical Herald of the South of Russia. 2020;11(4):6-23. (In Russ.) https://doi.org/10.21886/2219-8075-2020-11-4-6-23
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