FEATURES OF PROPHYLAXIS OF POSTOPERATIVE VENOUS THROMBOEMBOLISM IN ONCOLOGIC PATIENTS
https://doi.org/10.21886/2219-8075-2014-4-54-57
Abstract
Purpose: to study methods of prophylaxis of venous thromboembolism (VTE) in oncologic patients.
Materials and methods: results of treatment of 92 patients with various options of an abdominal cancer were analysed. 43 patients (I group) received low-molecular-weight heparin (LMWH) as agent of anticoagulant prevention (enoxaparin 40 mg subcutaneuosly per day for 10 days). The 2nd group was presented by 49 patients, not received anticoagulant therapy. Coagulation profiles, D-dimers and liver function tests were studied.
Results: in I group popliteal vein thrombosis was revealed in 2 (4,7%) cases. In two patients (4,7%) varicothromboflebitis was revealed. In 2nd group femoropopliteal thrombosis was diagnosed in 5 patients (10,2%) and thrombosis of superficial veins of lower extremities in 3 patients (6,1%).
Summary: it is more preferable to use LMWH for prevention of VTE. An adequate laboratory control in such patients and selection of an individual dose depends on results of APTT (activated partial thromboplastin time). Especially it concerns to patients with metastatic liver cancer and another groups of high-risk cancer patients.
About the Authors
I. I. Katelnitskyy
Rostov State Medical University
Russian Federation
Department of surgical diseases №1
Russian Federation
Department of surgical diseases №1
O. I. Kit
Rostov oncological research institute
Russian Federation
Russian Federation
O. V. Katelnitskaya
Rostov oncological research institute
Russian Federation
Russian Federation
I. I. Prostov
Rostov State Medical University
Russian Federation
Department of surgical diseases №1
Russian Federation
Department of surgical diseases №1
A. V. Ivashenko
Rostov Railway Hospital
Russian Federation
Russian Federation
K. A. Tumanova
Rostov oncological research institute
Russian Federation
Russian Federation
References
1. Trousseau A. Phlegmasia alba dolens. Lectures on clinical medicine, delivered at the Hotel-Dieu, Paris/ A. Trousseau. – London: New Sydenham Society, 1872. - P.281-295.
2. Онкология: учеб. для вузов/. Под ред. М. И. Давыдов, Ш. Х. Ганцев. -Москва: ГЭОТАР-Медиа, 2013. -912 с.
3. Nader Hanna, Kaloyan A., Birkov et al. Impact of venous thromboembolism on mortality of elderly Medicare patients with stage III colon cancer //The Oncologist. – 2012. – V.17. – P. 1191-1197.
4. Agnelli G, Bolis G, Capussotti L, et al. A clinical outcome-based prospective study on venous thromboembolism after cancer surgery: The @RISTOS project. //Ann Surg. – 2006. – V.243. – P.89–95.
5. Нарушения системы гемостаза у онкологических больных / О.А. Тарабрин, А.И. Мазуренко // Достижения биологии и медицины. Одесский национальный медицинский университет. – Одесса. – 2012. – том 1. – №12. – с. 23-25.
6. Rasmussen M.C., WilleJorgensen P., Jorgensen L.N. Postoperative fatal pulmonary embolism in a general surgical department// Amer. J. Surg. – 1995. – Vol. 169. – P. 214–216.
7. Gary H. Lyman, Alok A. Khorana, Anna Falanga et al. American Society of Clinical Oncology Guideline: Recommendations for Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer. //Journal of Clinical Oncology, vol. 25, n 34, 2007. p. 5490- 5505.
8. Lyman GH1, Khorana AA, Falanga A. Thrombosis and cancer: emerging data for the practicing oncologist. Am Soc Clin Oncol Educ Book. 2013.oi:1200/EdBook_AM.2013.33.e337.
9. Khorana AA, Francis CW, Culakova E, et al. Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients. //Cancer. – 2007. – V.110. – P. 2339–2346.
Review
For citations:
Katelnitskyy I.I., Kit O.I., Katelnitskaya O.V., Prostov I.I., Ivashenko A.V., Tumanova K.A. FEATURES OF PROPHYLAXIS OF POSTOPERATIVE VENOUS THROMBOEMBOLISM IN ONCOLOGIC PATIENTS. Medical Herald of the South of Russia. 2014;(4):54-57. (In Russ.) https://doi.org/10.21886/2219-8075-2014-4-54-57
Views:
372
Email this article 