To the problem of essential early diagnostics of funicular myelosis

Abstract

Purpose: to assess indices of peripheral blood and marrow of patients with funicular myelosis in comparison with anamnesis data in order to establish the reason of mielinopathy development to prescribe early pathogenic therapy.
Material and Methods: 25 patients aged 42-79, with verified funicular myelosis, having various possible reasons of myelinopathy development in anamnesis. The received results: the assessment of indices of peripheral blood and marrow revealed changes characteristic of В12 deficiency anaemia. Early diagnostics of В-12 deficiency anaemia and well-timed beginning of treatment have been shown to result in complete regression of clinical symptoms of funicular myelosis in all patients, whereas in cases with prolongation of the disease for more than 6 months even adequate therapy resulted only in partial regression of neurologic symptomatology.
Summary: presence of clinical sings of funicular myelosis, even at absence of changes of laboratory blood indices, requires more profound examination and more scrupulous anamnesis taking.