Experience of Neuroblastoma Treatment in Children and Teenagers (Materials of Pediatric Oncology Department of Rostov Cancer Research Institute for 2001–2009)

Abstract

Purpose: Analysis of clinical material in the group of patients with neuroblastoma for the period 2001-2009, summary of the material, assessment of treatment results.
Materials and Methods: 79 patients with neuroectodermal tumours.
Results: Patients have been analyzed depending on sex, age, stage of the disease, prognostic factors, site of the primary focus and secondary affection. We analyzed immediate and long-term results of neuroblastoma treatment with various regimes of complex treatment including administration of cytostatics on automedia of organism (autoblood, autoplasma): AHCT - autohemochemotherapy, APCT – autoplasmochemotherapy, as well as use of biotherapy (chemicals of transretinoic acid).
Summary: Most patients at the time of diagnosis are III and IV stages of cancer (85-90%); 50% of affected children under three years old. When localized stage 100% of the patients are alive with different period of observations. Child survival with III and IV stage disease should not exceed 20%. Treatment of this category of patients remained difficult challenges. Effectiveness requires further study of biotherapy.