Preventive Maintenance of Bacterial Complications at Newborns with the Respiratory Distress-Syndrome by Human Recombinant granulocyte Colony-Stimulating Factor
Abstract
Purpose: Definition of immunological criteria of purpose of rhGCSF became research aim newborns with respiratory distress syndrome, being on PPV.
Materials and Methods: At 64 newborns determined at receipt: G-CSF, FRF, sFas, IL-6, IL-8, IL-4, IL-1, TNF (IFA), subpopulational structure of lymphocytes and level of lymphocytes in early and late apoptosis (flow cytometry with colouring annexin and propidium iodide; Beckman Coulter Epics, USA).
Summary: Criteria for prescription of rhGCSF are decrease of plasma level of endogenous hr-GCSF low 1556 pg/ml and increase of lymphocytes, being in early and late apoptosis, above 9,5% and 0,56% (accordingly). Realization of randomized studies use rh-GCSF at newborns to development of neutropenic is necessary.
About the Authors
M. G. Puchtinskaya
Rostov Scientific Research Institute of Obstetrics and Pediatrics
Russian Federation
43 Mechnikova st., Rostov-on-Don, 344013
Russian Federation
43 Mechnikova st., Rostov-on-Don, 344013
V. V. Estrin
Rostov Scientific Research Institute of Obstetrics and Pediatrics
Russian Federation
43 Mechnikova st., Rostov-on-Don, 344013
Russian Federation
43 Mechnikova st., Rostov-on-Don, 344013
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Review
For citations:
Puchtinskaya M.G., Estrin V.V. Preventive Maintenance of Bacterial Complications at Newborns with the Respiratory Distress-Syndrome by Human Recombinant granulocyte Colony-Stimulating Factor. Medical Herald of the South of Russia. 2010;(2):50-53. (In Russ.)
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