Cell Composition of Cord Blood and G-Scf-Mobilized Blood Transplantational Material
Abstract
Cord blood cell composition is a short-lasting delivery stress consequence and is similar on adult G-CSF-mobilized peripheral blood. G-SCF realizes biological effect by number of secondary messengers, many of which are also natural effectors of stress. In this research comparative characteristics of cell composition, including lymphocytes subpopulations, CD34+ and CD133+ cells, hematopoietic progenitor cells colony-forming activity and mobilizing cytokines concentration (IL-8, MMP-2, MMP-9), between term newborns cord blood and G-SCF-mobilized peripheral blood is shown.
Mobilized cytokines concentration ratio in combination with CD34+ cells count in cord blood and mobilized peripheral blood suggests that delivery stress possibly is not single cause of cord blood features.
About the Authors
R. Sh. Ibragimov
Federal Research Center of pediatric hematology, oncology and immunology
Russian Federation
117/2 Leninskiyi pr., Moscow. 117997
Russian Federation
117/2 Leninskiyi pr., Moscow. 117997
E. V. Raikina
Federal Research Center of pediatric hematology, oncology and immunology
Russian Federation
117/2 Leninskiyi pr., Moscow. 117997
Russian Federation
117/2 Leninskiyi pr., Moscow. 117997
E. Yu. Osipova
Federal Research Center of pediatric hematology, oncology and immunology;
Moscow stem cell bank
Russian Federation
Russian Federation
117/2 Leninskiyi pr., Moscow. 117997;
31 Bakinskaya st., Moscow, 115516
O. A. Maiorova
Federal Research Center of pediatric hematology, oncology and immunology
Russian Federation
117/2 Leninskiyi pr., Moscow. 117997
Russian Federation
117/2 Leninskiyi pr., Moscow. 117997
M. V. Yakovleva
Moscow stem cell bank
Russian Federation
31 Bakinskaya st., Moscow, 115516
Russian Federation
31 Bakinskaya st., Moscow, 115516
S. A. Roumiantsev
Federal Research Center of pediatric hematology, oncology and immunology
Russian Federation
Russian Federation
117/2 Leninskiyi pr., Moscow. 117997
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Review
For citations:
Ibragimov R.Sh., Raikina E.V., Osipova E.Yu., Maiorova O.A., Yakovleva M.V., Roumiantsev S.A. Cell Composition of Cord Blood and G-Scf-Mobilized Blood Transplantational Material. Medical Herald of the South of Russia. 2010;(2):26-34. (In Russ.)
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