Influence of an Ante- and Intranatal Factors on Cord Blood Cell Composition of Fullterm Newborns
Abstract
The hypoxia is the powerful stressful factor, and, presumably, should result not only in rising of erythrocytes counts for the compensatory purpose, but also in rising of other blood cells number, as consequence of mobilization in the answer stress.
In article the influence assessment of pregnancy and delivery features, acute and chronic fetal hypoxia on cord blood cell composition of the full-term newborns is shown. Increase of leucocytes count at elongation of the second period of delivery, presence of chronic prenatal hypoxia or acute hypoxia in delivery is revealed. Differences of cord blood cell composition depending on newborn gender and body weight which consist in higher leucocytes count (all subpopulations including hematopoietic stem cells) at boys and at higher body weight are shown. Differences according to gender and to body weight are independent from each other. It is shown, that boys worse adapt for delivery that is expressed in higher concentration of mobilization cytokines and higher leucocytes and hemopoietic progenitors count in cord blood. It is shown, that mobilization cytokine concentration (IL-8, G-CSF, MMP-9) in cord blood of full-term newborns statistically significantly above, than in peripheral blood of healthy donors. Thus IL-8, G-CSF, MMP-9 concentration higher at boys in comparison with girls; at normal delivery in comparison with delivery by planned cesarean sections and at acute fetal hypoxia.
About the Authors
S. A. Roumiantsev
Federal Research Center of pediatric hematology, oncology and immunology
Russian Federation
117/2 Leninskiyi pr., Moscow. 117997
Russian Federation
117/2 Leninskiyi pr., Moscow. 117997
O. A. Mayorova
Federal Research Center of pediatric hematology, oncology and immunology
Russian Federation
117/2 Leninskiyi pr., Moscow. 117997
Russian Federation
117/2 Leninskiyi pr., Moscow. 117997
N. N. Zimina
Moscow Center of family planning and reproduction
Russian Federation
24 «А» Sevastopolsky avenue, Moscow, 117209
Russian Federation
24 «А» Sevastopolsky avenue, Moscow, 117209
M. V. Yakovleva
Moscow stem cell bank
Russian Federation
31 Bakinskaya st., Moscow, 115516
Russian Federation
31 Bakinskaya st., Moscow, 115516
M. A. Kurtser
Moscow Center of family planning and reproduction
Russian Federation
24 «А» Sevastopolsky avenue, Moscow, 117209
Russian Federation
24 «А» Sevastopolsky avenue, Moscow, 117209
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Review
For citations:
Roumiantsev S.A., Mayorova O.A., Zimina N.N., Yakovleva M.V., Kurtser M.A. Influence of an Ante- and Intranatal Factors on Cord Blood Cell Composition of Fullterm Newborns. Medical Herald of the South of Russia. 2010;(2):18-25. (In Russ.)
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