Extractionno-Photometric Determination of Diabenol
Abstract
Purpose: To study spectral and physicochemical characteristics Diabenol’s ion-associates and extraction equilibria and to develop a method for determination of small amounts of substance in the presence of other compounds.
Materials and Methods: An extraction-photometric method of analysis was chosen because it is widely used in pharmaceutical analysis and find a use in chemico-toxiological researches.
Results: It was developed a method of extraction-photometric detection of dosage forms with small amounts of diabenol in the presence of substance that prevent its detection with the methods of titrimetric analysis and ultraviolet spectroscopy. The investigation showed that the use of chloroform as extraction agent of diabenol ion-associates and anionic dyes is optimal.
Summary: This method makes possible to detect the basic substance with high precision and repeatability of measurements.
About the Authors
O. I. Ascalepova
Rostov State Medical University; South Federal University
Russian Federation
Russian Federation
Chemistry and Pharmacytical Chemistry Department, 29 Nakhichevansky st., Rostov-on-Don, 344022;
Analytic Chemistry Department, 7 Zorge st., Rostov-on-Don, 344058
I. E. Nicanorova
Rostov State Medical University
Russian Federation
Russian Federation
Chemistry and Pharmacytical Chemistry Department
29 Nakhichevansky st., Rostov-on-Don, 344022
V. A. Anisymova
Research Institute of Physical and Organic Chemistry of South Federal University
Russian Federation
194/2 Stachki av., Rostov-on-Don, 344090
Russian Federation
194/2 Stachki av., Rostov-on-Don, 344090
References
1. А.А.Спасов, И.Н.Иёжица, Л.И.Бугаева, В.А.Анисимова. Спектр фармакологической активности и токсикологические свойства производных бензимидазола //Химико-фармацевтический журнал. – 1999. - №5. - С. 6-17.
2. А.А.Спасов, Л.А.Смирнова, И.Н. Иёжица, С.А.Сергеева, А.А.Озеров. Фармакокинетика некоторых производных бензимидазола //Вопросы медицинской химии. – 2001. - Том 47, №4. - С.233-258.
3. M.A.Samotrueva, S.A. Khivrina, A.B.Matveev. Some Aspects of Immunomodulatory Effects of New Benzimidazole Deriveties// Bulletin of Experimental Biology and Medicine. - Vol.139, No. 1. – 2005.
4. I.G. Popovich, M.A. Zabezhinski, P.A. Egormin, et al. Insulin in aging and cancer: antidiabetic drug diabenol as geroprotector and anticarcinogen //The International Journal of Biochemistry & Cell Biology. – 2005. – №37. – P. 1117-1129.
5. Патент RU 2061481 С1. Средство, обладающее антиагрегационной активностью. Анисимова В.А.
6. Патент FR 2 691 462-A1.Nouveaux derives du benzimidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. Anisimova V.A.
7. Патент US 5623073. Benzimidazole compounds. Anisimova V.A.
8. Коренман И.М. Экстракция в анализе органических веществ. - М., 1977.
9. Булатов М.И., Калинкин И.П. Фотометрические методы анализа. – М., 1986. - 432с.
Review
For citations:
Ascalepova O.I., Nicanorova I.E., Anisymova V.A. Extractionno-Photometric Determination of Diabenol. Medical Herald of the South of Russia. 2011;(4):24-28. (In Russ.)
Views:
348
Email this article 