Intensifity of Lipid Peroxidation and Antioxidant Status at Patients with Different Types of Cardiovascular Disease
Abstract
Purpose: The estimation of lipid peroxidation and antioxidant status at patients with acute form of myocardial infarction and postinfarction cardiosclerosis.
Materials and Methods: Erythrocytes and plasma of venous blood were taken from 200 patients.
Results: It was established that acute course of myocardial infarction characterized by intensification of lipid peroxidation. On our opinion, the hyperproduction of hydrogen peroxide is leading mechanism in vessel tense regulation. Tissue hypoxia was found at postinfarction cardiosclerosis, we suppose that it activates the tissue macrophages and stimulates the synthesis of intercellular matrix components.
Summary: the orientation and degree of manifestation of activity changes of plasma and erythrocytic superoxide dismutase can serve as prognostic criterion of myocardial infarction.
About the Authors
Z. I. Mikashinowich
Rostov State Medical University
Russian Federation
Russian Federation
General and Clinic Biochemistry Department №1
29 Nakhichevansky st., Rostov-on-Don, 344022
E. V. Olempieva
Interdepartmental Study and Methodology Centre UFSB of Rostov Region
Russian Federation
Russian Federation
31 B.Sadovaya st., Rostov-on-Don, 344082
R. A. Gridasova
Rostov State Medical University
Russian Federation
Russian Federation
General and Clinic Biochemistry Department №1
29 Nakhichevansky st., Rostov-on-Don, 344022
A. A. Schwezov
Rostov State Medical University
Russian Federation
Russian Federation
General and Clinic Biochemistry Department №1
29 Nakhichevansky st., Rostov-on-Don, 344022
I. Y. Dementyeva
Rostov State Medical University
Russian Federation
Russian Federation
General and Clinic Biochemistry Department №1
29 Nakhichevansky st., Rostov-on-Don, 344022
T. D. Kovalenko
Rostov State Medical University
Russian Federation
Russian Federation
General and Clinic Biochemistry Department №1
29 Nakhichevansky st., Rostov-on-Don, 344022
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Review
For citations:
Mikashinowich Z.I., Olempieva E.V., Gridasova R.A., Schwezov A.A., Dementyeva I.Y., Kovalenko T.D. Intensifity of Lipid Peroxidation and Antioxidant Status at Patients with Different Types of Cardiovascular Disease. Medical Herald of the South of Russia. 2011;(3):33-37. (In Russ.)
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