Kindling-Induced Stress Disturbances of Immunologiocal Organs and Suprarenal Glands Under Conditions of Ketogenig Diet Usage
Abstract
Purpose: To study animal’s stress manifestation in the course of formation of a kindling epileptic syndrome in the conditions of application of a ketogenic diet.
Materials and Methods: Experiment was hold on rats which were simulated corazol kindling by 25,0 mg/kg, i.p.daily injection during 21 day Results: The decreasing of the weight of spleen, thymus along with simultaneous increasing of the weight of suprarenal glands and enlargement of the cortical and medullar layers have been seen. Besides, heightened level of corticotropin, corticosteron and gastrin have been registered in blood.
Summary: It was established that ketogenic diet (80% of lipids, 3,35 carbohydrates and 16,7 % of proteins) prevented kindlinginduced deteriorations and this effect was more pronounced in case of four weeks ketogenic diet treatment.
Keywords
kindling,
ketogenic diet,
suprarenal glands,
spleen,
thymus,
corticotrophin,
corticosterone,
gastrin
About the Author
V. A. Polyasny
Odessa National Medical University
Ukraine
2 Valikhovskiy lane, Odessa 65082
Ukraine
2 Valikhovskiy lane, Odessa 65082
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Review
For citations:
Polyasny V.A. Kindling-Induced Stress Disturbances of Immunologiocal Organs and Suprarenal Glands Under Conditions of Ketogenig Diet Usage. Medical Herald of the South of Russia. 2012;(3):48-51. (In Russ.)
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