Pharmacokinetics studying fenibut in experiment at pregnancy

Abstract

Purpose: To spend an estimation of parities between the maintenance fenibut in plasma of blood and a brain of rats and its maintenance in a placenta and an organism of embryos of rats.

Materials and Methods: Experimental researches are spent on 124 pregnant females of rats. The preparation was entered in a stomach, unitary in doses of weight of an animal by of 100 and 200 mg/kg. Through 5, 10, 20, 40 mines, 1 h 20 min, 2 h 40 min., 6 and 12 hours after preparation introduction took samples of blood, a brain, a placenta, an embryos and waters about an embryo.

Results: The maximum concentration fenibut in all bodies and fabrics is reached on 40 minute, then throughout 6 hours stable level of a preparation with constant smooth decrease is observed that quite arranges obstetrics clinic as in the course of regulation of the patrimonial certificate are especially important stability, duration and absence of sharp jumps in concentration of a preparation.

Summary: The preparation greatest quantity concentrates in the basic body of the appendix – a brain. The least quantity fenibut gets to an embryo. The obtained data confirms expediency of use fenibut in obstetrics clinic.