Opportunities proteomic the analysis of fibers of urine for an estimation of progressing of a chronic heart failure
Abstract
Purpose: To reveal, what changes of fibers of a pattern of urine at sick are connected by a chronic heart failure (CHF) with increase of a functional class (FC) of disease.
Materials and Methods: 90 patients with CHF II-IV FC are surveyed. Control group practically healthy 30 patients. Differentiated allocation separate proteins and fibers of urine of patients made by means of weights-spectrometry.
Results: At patients CHF in structure of fibers of urine markers of alteration of kidneys, connected with structural transformation. Progressing CHF up to a final stage it is connected with increase of occurrence β-sarcoglican, similar to tolloids fiber 2 and L-antigen. Among contracting fibers in process of increase FC CHFoccurrence cation-transport ATP decreases, and isoforms 1 fiber 6, connected with microtubuls – raises, that causes reduction of activity of receipt of calcium in sarcoplasmic rethiculum in nephrocytes and endoteliocytes vessels of kidneys.
Summary: Changes of an albuminous spectrum of urine at patients CHF it is information are significant for the forecast of progressing of a basic disease.
About the Authors
M. M. Batyushin
Rostov State Medical University
Russian Federation
Russian Federation
Department of Internal Medicine № 1
29 Nakhichevansky st., Rostov-on-Don, 344022
N. S. Vrublevskaya
Rostov State Medical University
Russian Federation
Russian Federation
Department of Internal Medicine № 1
29 Nakhichevansky st., Rostov-on-Don, 344022
I. V. Sarvilina
Rostov State Medical University
Russian Federation
Russian Federation
Department of Internal Medicine № 1
29 Nakhichevansky st., Rostov-on-Don, 344022
References
1. Go A.S., Yang J., Ackerson L.M. et al. Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) Study // Circulation. – 2006. – № 113(23). – P. 2713–2723.
2. Elsayed E.F., Tighiouart H., Griffith J. Cardiovascular Disease and Subsequent Kidney Disease //Arch. Intern. Med. – 2007. – № 167. – P. 1130–1136.
3. Смирнов А.В., Добронравов В.А., Каюков И.Г. Кардиоренальный континуум: патогенетические основы превентивной нефрологии //Нефрология. – 2005. – № 9(3). – C. 7–15.
4. Шутов A.M., Мардер Н.Я., Хамидулина Г.А., Myхорин В.П., Машина Т.В., Антонова С.В. Хроническая сердечная недостаточность у больных с хронической болезнью почек // Нефрология и диализ. – 2005. – № 7(2). – C. 140–144.
5. Lee Y.A., Liang C.S., Lee M.A., Lindpaintner K. Local stress, not systemic factors, regulate gene expression of the cardiac reninangiotensin system in vivo: a comprehensive study of all its components in the dog //Proc. Nath. Acad. Sci. USA. – 2006. – № 93(20). – P. 11035–11040.
Review
For citations:
Batyushin M.M., Vrublevskaya N.S., Sarvilina I.V. Opportunities proteomic the analysis of fibers of urine for an estimation of progressing of a chronic heart failure. Medical Herald of the South of Russia. 2011;(1):33-38. (In Russ.)
Views:
345
Email this article 