THE ROLE OF ANTIOXYDANT ENZYMES IN PATHOGENESIS OF ARTERIAL HYPERTENSION AT TEENAGERS
https://doi.org/10.21886/2219-8075-2013-3-60-62
Abstract
Purpose: to study antioxidant enzymatic state of rythrocytes at arterial hypertension (AH) at teenagers.
Materials and methods: venous blood taken from cubital vein and stabilized by heparin was used for investigation. 20 teenagers from 13 to 16 years was examinated. Main antioxidant enzymes: superoxidedismutase (SOD), catalase, glutathione reductase (GR), glutathione peroxidase (GPO) and level of reductive form of glutathione (GSH) were investigated in the purpose to estimate the state of antioxidant system.
Results: teenagers with AH has had dysbalance in the first line of antioxidant system (increasing SOD activity and inhibition of catalase) in combination with more intensive work of second line of antioxidant enzymes (significant activation of GPO).
Summary: clinico-biochemical analisis has shown that nonspecific adaptational changes have formed at teenagers that can be included into laboratory algorithms of diagnostic of AH.
About the Authors
Z. I. Mikashinowich
Rostov State Medical University
Russian Federation
Russian Federation
Department of common and clinical biochemistry №1
29 Nakhichevansky st., Rostov-on-Don, 344022
G. J. Nagornaya
Rostov State Medical University
Russian Federation
Russian Federation
Clinico-diagnostic laboratory
29 Nakhichevansky st., Rostov-on-Don, 344022T. D. Kovalenko
Rostov State Medical University
Russian Federation
Russian Federation
Clinico-diagnostic laboratory
29 Nakhichevansky st., Rostov-on-Don, 344022References
1. Титов В.Н. Основы патогенетической классификации форм артериальной гипертонии // Российский кардиологический журнал. – 2009. – С. 79-95.
2. Образцова Г.И. Факторы, влияющие на развитие артериальной гипертензии у детей и подростков: дисс. д. мед. наук. – Санкт-Петербург, 2009. – С. 104
3. Perkovic V., Huxley R., Wu Y. et al. // Hypertension. – 2007. – V.50. – P.991-997.
4. Саркисян О.Г. Особенности изменений метаболических процессов при атрофических кольпитах и их коррекция: дисс. …канд. мед. наук. – Ростов-на-Дону, 2000. – С. 15.
5. Королюк М.А., Иванова Л.И., Майорова И.Г. и др. // Лаб. дело. – 1988. - № 1. – С. 16-19.
6. Моин В.М. Простой и специфический метод определения активности глутатионпероксидазы в эритроцитах // Лаб. дело. – 1986. - № 12. – С. 724-727.
7. Юсупова Л.Б. О повышении точности определения активности глутатионредуктазы эритроцитов // Лаб. дело. – 1989. - № 4. – С. 19-21.
8. Ellman G.L. Tissue sulfhydryl groups // Arch. Biochem. Biophys. – 1959. – V.82. – P. 70-77.
9. Зенков Н.К., Ланкин В.З., Меньщикова Е.Б. Окислительный стресс: биохимический и патофизиологический аспекты – М.: МАИК «Наука/ Интерпериодика». – 2001. – 343 с.
Review
For citations:
Mikashinowich Z.I., Nagornaya G.J., Kovalenko T.D. THE ROLE OF ANTIOXYDANT ENZYMES IN PATHOGENESIS OF ARTERIAL HYPERTENSION AT TEENAGERS. Medical Herald of the South of Russia. 2013;(3):60-62. (In Russ.) https://doi.org/10.21886/2219-8075-2013-3-60-62
Views:
586
Email this article 