New quality criteria for fresh frozen plasma
Elena V. Ryabikina,
Elena A. Chernogubova,
Yuri V. Shatokhin,
Irina V. Snezhko,
Olga V. Gerasimova,
Elvira E. Kudinova https://doi.org/10.21886/2219-8075-2019-10-1-65-71
Abstract
Objective: development of new quality criteria for fresh frozen plasma. Matherials and methods: at diff erent times of storage of fresh frozen plasma harvested standardly and from the donors aft er Biolan exposure, the parameters of the kallikrein-kinin system were determined: the activity of kallikrein, the inhibitory activity of the α1 -proteinase inhibitor, α2 -macroglobulin, the total arginine-esterase activity and the level of prekallikrein. Results: during the quarantine process of fresh frozen plasma, prepared in a standard way, the processes of proteolysis activation is noticed already by 10th day from the beginning of FFP storage, and the preparation of donors for the blood donation with help of the biolan adaptogen provides better preservation of the components of the kallikrein-kinin system. Conclusions: analysis of the main components of the kallikrein-kinin system can be used as an additional criterion of the quality of fresh frozen plasma before the transfusion procedure.
About the Authors
Elena V. Ryabikina
Rostov State Medical University
Russian Federation
PhD, assistant professor of the Department of Hematology and Transfusiology with the courses of clinical laboratory diagnostics, genetics and laboratory genetics of faculty of professional development and training
Russian Federation
PhD, assistant professor of the Department of Hematology and Transfusiology with the courses of clinical laboratory diagnostics, genetics and laboratory genetics of faculty of professional development and training
Elena A. Chernogubova
Rostov State Medical University;
Federal Research Center of the Southern Scientifi c Center of the Russian Academy of Sciences
PhD, Leading researcher
PhD, Leading researcher
Yuri V. Shatokhin
Rostov State Medical University
MD, professor of the Department of Hematology and Transfusiology with courses in clinical laboratory diagnostics, genetics and laboratory genetics of faculty of professional development and training
MD, professor of the Department of Hematology and Transfusiology with courses in clinical laboratory diagnostics, genetics and laboratory genetics of faculty of professional development and training
Irina V. Snezhko
Rostov State Medical University
PhD, аssociate Professor of the Department of Hematology and Transfusiology with courses in clinical laboratory diagnostics, genetics and laboratory genetics of faculty of professional development and training
PhD, аssociate Professor of the Department of Hematology and Transfusiology with courses in clinical laboratory diagnostics, genetics and laboratory genetics of faculty of professional development and training
Olga V. Gerasimova
Rostov State Medical University
assistant professor of the Department of Hematology and Transfusiology with the courses of clinical laboratory diagnostics, genetics and laboratory genetics of faculty of professional development and training
assistant professor of the Department of Hematology and Transfusiology with the courses of clinical laboratory diagnostics, genetics and laboratory genetics of faculty of professional development and training
Elvira E. Kudinova
Blood Transfusion Station of the Rostov Region
head. zonal laboratory of immunological typing of the tissues
head. zonal laboratory of immunological typing of the tissues
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Review
For citations:
Ryabikina E.V., Chernogubova E.A., Shatokhin Yu.V., Snezhko I.V., Gerasimova O.V., Kudinova E.E. New quality criteria for fresh frozen plasma. Medical Herald of the South of Russia. 2019;10(1):65-71. (In Russ.) https://doi.org/10.21886/2219-8075-2019-10-1-65-71
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