METABOLIC CHANGES IN HEPATOCYTES OF EXPERIMENTAL ANIMALS AFTER PROLONGED TREATMENT WITH SIMVASTATIN
https://doi.org/10.21886/2219-8075-2013-1-42-45
Abstract
Purpose: To analyse the metabolic changes in the liver cells of experimental animals after prolonged treatment with simvastatin.
Materials and Methods: Our experiment was taken on 40 rates (males) which were divided on two groups: 1-st (control) – 20 intact animals; 2-nd (experimental) – 20 animals who took simvastatin during 3 months (Zocor, 20 mg) on 1,5 mg once per day.
Results and Summary: Estimation the level of glycolysis metabolites, activity of enzymes of carbohydrates and energetic metabolism and antioxidant protection gave us possibility to established that one of the pathophysiologic damage of liver functions after the prolonged treatment with statins was hypoxia which characterized by decreasing velocityof key pathways of energetic metabolism and decreasingof powerof enzymatic antioxidant defense.
About the Authors
Z. I. Mikashinovich
Rostov State Medical University
Russian Federation
Russian Federation
Department of Common and Clinical Biochemistry №1
29 Nakhichevansky st., Rostov-on-Don, 344022E. S. Belousova
Rostov State Medical University
Russian Federation
Russian Federation
Department of Common and Clinical Biochemistry №1
29 Nakhichevansky st., Rostov-on-Don, 344022E. G. Telesmanich
Rostov State Medical University
Russian Federation
Russian Federation
Department of Common and Clinical Biochemistry №1
29 Nakhichevansky st., Rostov-on-Don, 344022References
1. Кабалава Ж.Д., Виллевальде С.В. Статины в первичной профилактике сердечно-сосудистых заболеваний. // Терапевтический архив. – 2011. – Т. 83, №9. – С. 70-75.
2. Ito M.K. Dyslipidemia: management using optimal lipid-lowering therapy. // Annаles Pharmacotherapy. – 2012. – Vol. 46, 10. – P. 1368-1381.
3. Справочник по лабораторным методам исследований. / Под ред. Даниловой. Л.А. - СПб.: Питер, 2003. - 736 с.
4. Гуревич В.С., Конторщикова К.Н., Шатилина Л.В. Сравнительный анализ двух методов определения активности супероксиддисмутазы. // Лабораторное дело. - 1990. - № 4. - С. 44-47.
5. Биохимические исследования слюны в клинической практике. / Под ред. проф. Микашинович З.И. – Ростов н/Д, 2004. – 80 с.
6. Справочник по клинико-биохимическим исследованиям и лабораторной диагностике. / Под ред. Камышникова В.С. – М.: «МЕДпресс-информ», 2004. – 920 с.
7. Nordmann I.N. Determination the аctivitidehydrogenasique des mitochondries a 1-acid-dichloride-2,3,5-triphenyl-tetrazolium. // Bull. Sos. Chim. Biol. – 1957. – Vol. 33. - P. 189-197.
8. Кривченкова Р.С. Определение активности цитохромоксидазы в суспензии митохондрий. // Современные методы в биохимии. – М.: Медицина, 1977. – С. 47-49.
9. Дизрегуляционная патология системы крови. / Под ред. Гольдберга Е.Д., Крыжановского Г.Н. - М.: ООО «Медицинское информационное агентство», 2009. - 432 с.
10. Гипоксия: адаптация, патогенез, клиника. / Под ред. Шевченко Ю.Л. – СПб., 2000. – 350 с.
Review
For citations:
Mikashinovich Z.I., Belousova E.S., Telesmanich E.G. METABOLIC CHANGES IN HEPATOCYTES OF EXPERIMENTAL ANIMALS AFTER PROLONGED TREATMENT WITH SIMVASTATIN. Medical Herald of the South of Russia. 2013;(1):42-45. (In Russ.) https://doi.org/10.21886/2219-8075-2013-1-42-45
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