METABOLIC EFFECTS OF DIACAMPH HYDROCHLORIDE AND BEMITHYLUM IN RATS WITH CHRONIC IMMOBILIZATION STRESS MODEL UNDER THE CONDITIONS OF NORMOGLYCAEMIA AND ALLOXAN-INDUCED DIABETES MELLITUS

Abstract

Purpose. To evaluate the influence of diacamph hydrochloride and bemithylum on carbohydrate and energy metabolism, as well as pro-antioxidant balance in normoglycaemic rats and on the model of diabetes mellitus.

Materials and methods. Diacamph hydrochloride (25 mg/kg i.p.) and bemithylum (50 mg/kg i.p.) experimental therapy in normoglycaemic rats and ones with diabetes mellitus model under the conditions of immobilization during two weeks.
Results. In chronic immobilization stress, especially against the background of alloxan-induced diabetes mellitus there were pathological changes as follows: significant decrease of glycogen level in internal organs, appearance of lactate-acidosis, depletion of ATP pool, oxidative stress activation against the background of antioxidant protection exhaustion. Both diacamhp hydrochloride and bemithylum eliminated these impairments, diacamph hydrochloride was more effective in diabetes mellitus at that.
Summary. In chronic immobilization stress in normoglycaemic animals the diacamph hydrochloride and bemithylum exert comparable normalizing effect on carbohydrate and energy metabolism, as well as pro-antioxidant balance. Under the conditions of diabetes mellitus diacamph hydrochloride provides more marked effect than bemithylum.