PREEKLAMPSYA IN WOMEN WITH NUTRITIONAL OBESITY AND THERAPY OF RENAL DYSFUNCTION BEFORE DELIVERY
https://doi.org/10.21886/2219-8075-2015-3-104-107
Abstract
Purpose: To evaluate the effect of different treatment options preeclampsia (PE) on renal dysfunction in women with alimentary obesity (AO) before delivery.
Materials and Methods: A randomized study of 63 pregnant women with PE and AO. The average age - 27,4 Ѓ} 1,6 years. The first group - 31 women who underwent conventional therapy. The second - 32 women, therapy provides for the correction of renal dysfunction. Examined leptin, renin-angiotensin system (RAAS), VNS, adaptation circulation, kidney function.
Results: The high concentration of leptin activation of the RAAS, endothelial dysfunction and VNS aggravate kidney damage.
Summary: conducting therapy, taking into account existing renal dysfunction contributed to the restructuring of the circulatory adaptation, VNS and RAAS close to normal pregnancy, compensation of renal dysfunction.
About the Authors
S. S. Tumanyan
Rostov State Medical University
Russian Federation
Department of Anesthesiology and Intensive Care
Russian Federation
Department of Anesthesiology and Intensive Care
A. N. Rymashevskiy
Rostov State Medical University
Russian Federation
Department of Anesthesiology and Intensive Care
Russian Federation
Department of Anesthesiology and Intensive Care
S. V. Tumanyan
Rostov State Medical University
Russian Federation
Department obstetrics and gynecology №1
Russian Federation
Department obstetrics and gynecology №1
O. V. Keller
Rostov State Medical University
Russian Federation
Department of Anesthesiology and Intensive Care
Russian Federation
Department of Anesthesiology and Intensive Care
References
1. Медведь, В.И. Преэклампсия в клинике экстрагенитальной патологии / В.И. Медведь, Е.М. Дуда // Почки. – 2013. – № 3(5). – С. 36-38.
2. Хромылев, А.В. Метаболический синдром и беременность / А.В. Хромылев // Ожирение и метаболизм. – 2014. – № 2. – С. 3-7.
3. Петунина, Н.А. Роль гормонов жировой ткани в развитии осложнений беременности у женщин с ожирением / Н.А. Петунина, И.А. Кузина // Ожирение и метаболизм. – 2013. – № 1. – С. 3-8.
4. Мальцева, Н.В. Сравнительный анализ содержания α2 – микроглобулина и ассоциированного с беременностью протеина в крови и моче при нормальной беременности и гестозе / Н.В. Мальцева, В.Г. Левченко, В.Н. Зорина, А.А. Дубовик, Н.Н. Васильева // Бюллетень СО РАМН. – 2005. – №118 (4). – С. 119-126.
5. Мицич, Д. Роль лептина в нарушении репродуктивной функции при ожирении / Д. Мицич, Г. Цвийович, А. Кендерешки, М. Шумарац-Думанович, С. Зорич, Д. Пейкович, К. Маркович // Ожирение и метаболизм. – 2006. – № 3. – С. 2-8.
6. Misra, V.K. The Influence of Overweight and Obesity on Longitudinal Trends in Maternal Serum Leptin Levels During Pregnancy / V.K. Misra, S. Trudeau // Obesity. – 2011. – № 192. – P. 416–421.
7. Ingelsson, E. Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham offspring study / E. Ingelsson, M.J. Pencina, G.H. Tofler, et al. // Circulation. – 2007. – № 116. – P. 984–992.
8. Серов В.Н. Прогностическое значение состояния вегетативной нервной системы и артериальной гипертензии у беременных с гестозом / В.Н. Серов, И.И. Стольникова // Акушерство и гинекология. – 2006. – № 4. – С. 19‒22.
9. Cornelius Jungheinrich md. The starch family: are they all equal? Pharmacokinetics and pharmacodynamics of hydroxyethyl starches / Cornelius Jungheinrich md // Transfusion Alternatives in Transfusion Medicine. – 2007. – № 3 (9). – P. 152‒163.
10. Papafragkaki, D.K. Obesity and renal disease: A possible role of leptin / D.K. Papafragkaki, T George // Hormones. – 2005. – № 4 (2). – P. 90–95.
Review
For citations:
Tumanyan S.S., Rymashevskiy A.N., Tumanyan S.V., Keller O.V. PREEKLAMPSYA IN WOMEN WITH NUTRITIONAL OBESITY AND THERAPY OF RENAL DYSFUNCTION BEFORE DELIVERY. Medical Herald of the South of Russia. 2015;(3):104-107. (In Russ.) https://doi.org/10.21886/2219-8075-2015-3-104-107
Views:
416
Email this article 