ROLE OF IMPAIRED IRON METABOLISM IN THE DEVELOPMENT OF DISORDERS OF RHYTHM AND CONDUCTION IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
https://doi.org/10.21886/2219-8075-2015-3-95-100
Abstract
Purpose: to analyze the relationship between iron metabolism and rhythm and conduction disorders in the children with acute lymphoblastic leukemia (ALL).
Materials and Мethods: the children were studied over time: at admission to the clinic before the start of chemotherapy (Group 1a), after remission induction (Group 1b), and after discontinuation of intensive polychemotherapy (Group 1c).
Results: examination of iron metabolism in the children with ALL revealed significantly elevated serum iron level with increased iron transferring saturation index, ferritin and hepcidin levels and lower total iron binding capacity (TIBC) at all stages of polychemotherapy (PCT). Summary: the children with ALL demonstrated significant association between serum iron level and nomotopic automatism disorders (sinus tachy-, brady, arrhythmias) at all PCT stages; between serum iron level and extrasystoles appearance during and after discontinuation of the treatment; and also between serum ferritin level and myocardial depolarization disorders at all PCT stages and conduction disorders during and after discontinuation of the treatment.
About the Authors
A. A. Savisko
Rostov State Medical University
Russian Federation
Russian Federation
N. E Laguteeva
Rostov State Medical University
Russian Federation
Russian Federation
E. D. Tepliakova
Rostov State Medical University
Russian Federation
Russian Federation
A. V. Shestopalov
FSCCPHOI n.a. D. Rogachev
Russian Federation
Russian Federation
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Review
For citations:
Savisko A.A., Laguteeva N.E., Tepliakova E.D., Shestopalov A.V. ROLE OF IMPAIRED IRON METABOLISM IN THE DEVELOPMENT OF DISORDERS OF RHYTHM AND CONDUCTION IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA. Medical Herald of the South of Russia. 2015;(3):95-100. (In Russ.) https://doi.org/10.21886/2219-8075-2015-3-95-100
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