Diagnostic value of determination of baseline concentrations of С-reactive protein and interleukin-6 in blood to assess the risk of cardiovascular disease
https://doi.org/10.21886/2219-8075-2015-3-86-91
Abstract
Purpose: to identify the diagnostic value of simultaneous determination of baseline concentrations of С-reactive protein (CRP) and interleukin-6 levels in the blood in patients as additional factors in assessing the risk of cardiovascular disease by screening by specifying the intensity of inflammation.
Materials and methods: screening to identify cardiovascular risk and the concentration in the blood CRP and interleukin-6 in 304 patients urban populations in the outpatient polyclinic inspection and survey.
Results: set pairing between the increased risk on a scale SCORE, and the concentration of CRP in the blood. Diagnostic level of CRP in the blood to separate the risk of cardiovascular disease at the lowest and the highest was 3 mg/l. a closer link was established between the number of risk factors and the studied marker of inflammation.
Summary: when screening risk assessment should be carried out in the cardiovascular disease with quantitative measurement of CRP in the blood concentrations of the base.
About the Authors
M. I. Nazheva
Rostov state medical university
Russian Federation
Faculty of internal medicine № 2
Russian Federation
Faculty of internal medicine № 2
I. A. Demidov
Rostov state medical university
Russian Federation
Faculty of internal medicine № 2
Russian Federation
Faculty of internal medicine № 2
References
1. Байракова Ю.В., Баздырев Е.Д., Казачек Я.В., Каличенко Н.А. с соавт. Прогностическая роль С-реактивного белка в прогрессировании атеросклероза через год после коронарного шунтирования // Кардиология, 2013.-N 6.-С.40-45.
2. Макоева М.Х., Федорова М.М., Автандилов А.Г., Семитко С.П., Долгов В.В., Ройтман А.П. Динамика и прогностическое значение мозгового натрийуретического пептида и С-реактивного белка при остром инфаркте миокарда в зависимости от тактики лечения // Клиническая лабораторная диагностика. -2014.-N2.-С.23-26.
3. Гусев Е.Ю. С-реактивный белок: патогенетическое и диагностическое значение. // Уральский медицинский журнал, 2014.- N 1.-С.113-121.
4. Nissen S., Tuzcu E., Schoenhagen P. et al. Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) Investigators // N. Engl. J. Med. -2005. –Vol.352. –P.29–38.
5. Ridker P., Cannon C., Morrow D. et al. Pravastatin or Atorvastatin Evaluation and Infection Therapy Thrombolysis in Myocardial Infarction 22 (PROVE IT- TIMI 22) Investigators. C-reactive protein levels and outcomes after statin therapy // N. Engl. J. Med.- 2005.-Vol.352.–P.20–28.
6. Kotseva K., Wood D., De Backer G. et al. EUROASPIRE Study Group.EUROASPIRE III. Management of cardiovascular risk factors in asymptomatic high-risk patients in general practice: cross-sectional survey in 12 European countries. // Eur. J. Cardiovasc. Prev. Rehabil. -2010.Oct. –Vol.17.-N5.-P.530-540.
7. Андреевская Е.М., Минушкина Л.О. Оценка риска сердечно-сосудистых осложнений у женщин в перименопаузе: значение определения высокочувствительного С-реактивного белка // Российский медицинский журнал, 2014.-N1.-С.22-26.
8. Качковский М.А., Симерзин В.В., Рубаненко О.А., Кириченко Н.А. Гемостазиологические, липидемические и гемодинамические показатели, ассоциированные с риском смерти от сердечнососудистых заболеваний у пациентов из групп высокого и очень высокого риска по шкале SCORE // Терапевтический архив. -2014.-N3.-С.59-64.
9. Rose G. The strategyofpreventivemedicine. // Oxford: Oxford University Press.-1992. -278 p.
Review
For citations:
Nazheva M.I., Demidov I.A. Diagnostic value of determination of baseline concentrations of С-reactive protein and interleukin-6 in blood to assess the risk of cardiovascular disease. Medical Herald of the South of Russia. 2015;(3):86-91. (In Russ.) https://doi.org/10.21886/2219-8075-2015-3-86-91
Views:
508
Email this article 