INDICATORS OF CYTOKINE STATUS IN INFANTS WITH PERINATAL CNS DAMAGE TO MOTHERS WITH CHRONIC PLACENTAL NSUFFICIENCY
https://doi.org/10.21886/2219-8075-2015-3-78-81
Abstract
Purpose: the study of cytokine status in infants with perinatal CNS damage from mothers with placental insufficiency.
Materials and methods: were examined 95 newborns from mothers with chronic kidney disease. Control group – newborns from mothers with physiological pregnancy and childbirth(n = 19). The definition in the cord blood of newborns level of IL-6, TNF-alpha, IFN-g, IL-1β, IL-4 were performed by the method of enzyme immunoassay with the use of diagnostic kits “Cytokine”, St. Petersburg.
Results: for children from an early manifestation of perinatal Central nervous system from mothers with decompensated chronic kidney failure, by the increase in cord blood levels of IL-6, IL-1β, TNF-alpha , IFN-g, For children delayed manifestation of perinatal Central nervous system from mothers with asthma, chronic kidney failure, by the increase in the level of IL -6, TNFalpha, IL -4, IFN-g. For children, delayed manifestation of perinatal Central nervous system from mothers with compensated chronic kidney failure, by the increase in the level of IL -4, IFN-g, IL-6.
Summary: the development of perinatal CNS damage in newborns from mothers with chronic kidney disease associated with the violation of cytokine balance in cord blood, with a tendency to focus on Th1-type, which promotes the formation of inflammatory mode immune regulation.
About the Authors
M. A. Levkovich
Rostov research Institute of obstetrics and Pediatrics
Russian Federation
Russian Federation
V. A. Lindе
Rostov research Institute of obstetrics and Pediatrics
Russian Federation
Russian Federation
Т. G. Plakhotya
Rostov research Institute of obstetrics and Pediatrics
Russian Federation
Russian Federation
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Review
For citations:
Levkovich M.A., Lindе V.A., Plakhotya Т.G. INDICATORS OF CYTOKINE STATUS IN INFANTS WITH PERINATAL CNS DAMAGE TO MOTHERS WITH CHRONIC PLACENTAL NSUFFICIENCY. Medical Herald of the South of Russia. 2015;(3):78-81. (In Russ.) https://doi.org/10.21886/2219-8075-2015-3-78-81
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