NOOTROPICS AND MELAXEN’ NEUROPROTECTIONAL ACTIVITY MORPHOPHARMACOLOGICAL ANALYSIS IN RATS’ ACUTE CEREBRAL ISCHEMIA
https://doi.org/10.21886/2219-8075-2015-3-42-46
Abstract
purpose: оn the base of complex morpho-pharmacological analysis to evaluate nootropics and its combinations with melaxen effects in rats experimental acute cerebral ischemia.
materials and methods: morphological (light-, electron microscopic and morphometric) analysis of the experimental material
(frontal cortex and hippocampus) and lethality was studied on 21 white rats with induced by the ligation of bilateral common carotid arteries of acute cerebral ischemia and used a preventive course of nootropics (vinpocetine, piracetam) and melaxen.
results: it was established that preventive combined vinpocetine and melaxen usage significantly reduces rat’s lethality and brain ischemic damage degree, indicating obvious neuroprotective activity.
summary: the results obtained indicate significant potential importance of melatonin-based drugs usage for neuroprotection therapy emprovement in cerebral ischemia.
About the Authors
E. V. Gantsgorn
Rostov State Medical University
Russian Federation
Russian Federation
Pharmacology and Clinical Pharmacology Department, Histology, Cytology and Embryology Department
D. P. Khloponin
Rostov State Medical University
Russian Federation
Pharmacology and Clinical Pharmacology Department, Histology, Cytology and Embryology Department
Russian Federation
Pharmacology and Clinical Pharmacology Department, Histology, Cytology and Embryology Department
P. A. Khloponin
Rostov State Medical University
Russian Federation
Pharmacology and Clinical Pharmacology Department, Histology, Cytology and Embryology Department
Russian Federation
Pharmacology and Clinical Pharmacology Department, Histology, Cytology and Embryology Department
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Review
For citations:
Gantsgorn E.V., Khloponin D.P., Khloponin P.A. NOOTROPICS AND MELAXEN’ NEUROPROTECTIONAL ACTIVITY MORPHOPHARMACOLOGICAL ANALYSIS IN RATS’ ACUTE CEREBRAL ISCHEMIA. Medical Herald of the South of Russia. 2015;(3):42-46. (In Russ.) https://doi.org/10.21886/2219-8075-2015-3-42-46
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