SURGICAL ENDOINTOXICATION UNDER ENTERAL PROTEKTION THERAPY

Abstract

Purpose: to establish efficiency of enteral protection therapy in correction of a syndrome of endogenic intoxication at acute peritonitis.

Materials and methods: pilot studies on dogs (n=32) and clinical observations (n=46) are the basis for work. The acute purulent fibrinous peritonitis was modelled. After operation in dynamics series of biophysical and biochemical indicators of intestine structures, markers of endogenic intoxication were studied at the organ and organism levels.

Results: it is established that in development of endogenic intoxication syndrome at acute peritonitis the important role belongs to an enteral failure owing to membrane destruction phenomena because there were excessive intensity of lipids peroxidation, increased phospholipase activity and a hypoxia. The Remaksolum was effective in correction of an enteral failure and, as a result, in cupping of endogenic intoxication. Clinical and laboratory researches confirmed Remaksolum efficiency in cupping of endogenic intoxication at patients with acute peritonitis.

Summary: in the development of enteral insufficiency syndrome in acute peritonitis play a key role membranodestabiliziruyuschie phenomenon due to the high intensity of lipid peroxidation, increased phospholipase activity and hypoxia. Application remaxol in the early postoperative period pathogenetically substantiated and clinically advisable to correct the endogenous intoxication in acute peritonitis. The drug, possessing antioxidant, antihypoxic, fosfolipazdepres-sive action leads to stabilization of the phospholipid bilayer of cell membranes ki shechnika reduces the negative aspects of enteric disease.