Clinical features of depression in men with testosterone deficiency
https://doi.org/10.21886/2219-8075-2025-16-2-55-64
Abstract
Objective: to study the clinical features of depression in men with low testosterone levels. Materials and methods: the study included 140 males aged 18 to 65 years diagnosed with recurrent depressive disorder (F33) and a depressive episode (F32) according to ICD-10. The main group consisted of men with depression comorbid with testosterone deficiency (n = 90). The control group included men with depression and normal testosterone levels (n = 50). Results: symptoms of depression in men with testosterone deficiency were less severe and led to less functional disturbance. There were some clinical differences in symptoms and syndromes such as sexual function, sleep, irritability, alcohol consumption, severe and functionality, main syndrome etc. For the main group was more typical mono-episode with manifestation at a later age while for the control group recurrent episodes manifesting at an earlier age were more typical. Conclusions: depression in men with testosterone deficiency has a number of differences that must be taken into account when diagnosing and choosing treatment tactics.
Supporting agencies: The study was conducted within the framework of the state assignment of the Federal State Budgetary Educational Institution of Higher Professional Education Rostov State Medical university “Depression in Men with Testosterone Deficiency”.
About the Authors
Yu. Yu. Osadshiy
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Yuriy Yu. Osadshiy, Junior Research Fellow of the Department of Psychiatry and Narcology
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
M. N. Kryuchkova
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Marina N. Kryuchkova, Cand. Sci. (Med.), Associate Professor of the Department of Psychiatry and Narcology
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
A. A. Sidorov
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Alexey A. Sidorov, psychiatrist-narcologist at the Center for Psychological Support
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
A. Ya. Perekhov
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Aleksei Y. Perekhov, Cand. Sci. (Med.), Associate Professor of the Department of Psychiatry and Narcology
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
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Review
For citations:
Osadshiy Yu.Yu., Kryuchkova M.N., Sidorov A.A., Perekhov A.Ya. Clinical features of depression in men with testosterone deficiency. Medical Herald of the South of Russia. 2025;16(2):55-64. (In Russ.) https://doi.org/10.21886/2219-8075-2025-16-2-55-64
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