Angiotensinogen – a marker of non-developing pregnancy
https://doi.org/10.21886/2219-8075-2025-16-2-37-42
Abstract
Objective: to investigate the effects of angiotensinogen on the endometrium in missed abortion. Materials and methods: a prospective cohort that included 212 women, 160 with missed abortion and 52 with progressing pregnancies at 6–12 weeks. In all participants, the average serum concentration of angiotensinogen was measured. Additionally, a morphological examination of the endometrium was performed in patients with missed abortion. Results: women with missed abortion had significantly lower angiotensinogen levels compared to those with progressing pregnancies. Based on the results of a nonparametric analysis, there was a direct correlation between low angiotensinogen levels and spiral artery thrombosis in missed abortion patients at 11–12 weeks (r=0,37, p<0,01). Conclusion: these findings suggest that a decrease in angiotensinogen levels is associated with impaired angiogenesis in the endometrium and can lead to spiral artery thrombosis during on the endometrium in missed abortion.
About the Authors
A. A. Orazmuradov
Peoples’ Friendship University of Russia n. a. Patrice Lumumba
Russian Federation
Competing Interests:
Russian Federation
Agamurad A. Orazmuradov, Dr. Sci. (Med.), Prof., Depart. of Obstetrics and Gynecology with a course of perinatology, Medical Institute
Moscow
Competing Interests:
Authors declare no conflict of interest
Zh. Zh. Suleymanova
Peoples’ Friendship University of Russia n. a. Patrice Lumumba
Russian Federation
Competing Interests:
Russian Federation
Zhasmin Zh. Suleymanova, Depart. of Obstetrics and Gynecology with a course of perinatology, Medical Institute
Moscow
Competing Interests:
Authors declare no conflict of interest
E. A. Kuzmina
Peoples’ Friendship University of Russia n. a. Patrice Lumumba
Russian Federation
Competing Interests:
Russian Federation
Ekaterina A. Kuzmina, Depart. of Obstetrics and Gynecology with a course of perinatology, Medical Institute
Moscow
Competing Interests:
Authors declare no conflict of interest
I. N. Kostin
Peoples’ Friendship University of Russia n. a. Patrice Lumumba
Russian Federation
Competing Interests:
Russian Federation
Igor N. Kostin, Dr. Sci. (Med.), Prof., Depart. of Obstetrics and Gynecology with a course of perinatology, Medical Institute
Moscow
Competing Interests:
Authors declare no conflict of interest
Kh. Haddad
Peoples’ Friendship University of Russia n. a. Patrice Lumumba
Russian Federation
Competing Interests:
Russian Federation
Khalid Haddad, Cand. Sci. (Med.), Assistant, Depart. Of Obstetrics and Gynecology with a course of perinatology, Medical Institute
Moscow
Competing Interests:
Authors declare no conflict of interest
E. V. Mukovnikova
Peoples’ Friendship University of Russia n. a. Patrice Lumumba
Russian Federation
Competing Interests:
Russian Federation
Ekaterina V. Mukovnikova, Depart. of Obstetrics and Gynecology with a course of perinatology, Medical Institute
Moscow
Competing Interests:
Authors declare no conflict of interest
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Review
For citations:
Orazmuradov A.A., Suleymanova Zh.Zh., Kuzmina E.A., Kostin I.N., Haddad Kh., Mukovnikova E.V. Angiotensinogen – a marker of non-developing pregnancy. Medical Herald of the South of Russia. 2025;16(2):37-42. (In Russ.) https://doi.org/10.21886/2219-8075-2025-16-2-37-42
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