The case of multiple changes in genetically engineered biological therapy in a child with juvenile idiopathic arthritis
https://doi.org/10.21886/2219-8075-2025-16-1-68-73
Abstract
A clinical case of multiple changes in genetic engineering biological therapy in a child with juvenile idiopathic arthritis is presented. A detailed study of this pathology in recent years is associated with an increase in morbidity among the child population, as well as a large number of prognostically unfavorable outcomes of the disease. Particular progress has been made through the use of new approaches in the treatment of arthritis in children. Currently, the use of genetic engineering therapy in the treatment of rheumatic diseases is a highly effective method for reducing disability and improving the quality of life of patients. But at the same time, the issue of starting therapy, choosing a group of biologically active drugs and their timely change in the absence of effect remains relevant. A feature of this clinical case is the timely change in treatment tactics with repeated changes in the class of genetically engineered drugs. Over several years of using GIBP, 6 drugs were used that gave a positive, but short-term effect.
About the Authors
A. A. Lebedenko
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Alexander A. Lebedenko, Dr. Sci. (Med.), professor, Head of the Department of Pediatric Diseases No. 2
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
S. V. Maltsev
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Stanislav V. Maltsev, Dr. Sci. (Med.), Associate Professor, Head of the Department of Pediatric Diseases No. 2
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
A. N. Posevina
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Anastasia N. Posevina, Cand. Sci. (Med.), assistant at Head of the Department of Pediatric Diseases No. 2
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
K. V. Kineva
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Karina V. Kineva, pediatrician of the pediatric department of the clinic
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
E. B. Tyurina
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Elena B. Tyurina, Cand. Sci. (Med.), pediatrician of the pediatric department of the clinic
Rostov-on-Don
Competing Interests:
Authors declare no conflict of interest
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Review
For citations:
Lebedenko A.A., Maltsev S.V., Posevina A.N., Kineva K.V., Tyurina E.B. The case of multiple changes in genetically engineered biological therapy in a child with juvenile idiopathic arthritis. Medical Herald of the South of Russia. 2025;16(1):68-73. (In Russ.) https://doi.org/10.21886/2219-8075-2025-16-1-68-73
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