Clinical and immunological characteristics of patients with moderate COVID-19 with different lung lesion areas
https://doi.org/10.21886/2219-8075-2023-14-4-22-28
Abstract
Objective: to study the clinical and immunological parameters of patients with COVID-19 in moderate form with varying degrees of lung tissue damage.
Materials and methods: 80 patients hospitalized with a diagnosis of «COVID-19, moderate form; complication: bilateral polysegmental interstitial pneumonia» were examined. The difference in laboratory parameters (general clinical, biochemical and immunological) was evaluated depending on the degree of lung damage (up to 25 and up to 50%). Comparison group: 20 healthy volunteers.
Results: the differences between patients with different lung lesion areas consisted in higher levels of prognosis severity markers – CRP, LDH. In the immune status in the CT group 2, there was a decrease in CD3+ lymphocytes and their helper subpopulation, dysimmunoglobulinemia and a higher IL-6 content.
Conclusions: CT examination is of great importance for monitoring the progression of the disease. The smaller area of lung lesion reflects a lighter course of the disease, which does not exclude the need for dispensary observation and rehabilitation after discharge.
About the Authors
N. A. Skripkina
City Hospital № 1 n.a. N.A. Semashko
Russian Federation
Competing Interests:
Russian Federation
Nadezhda A. Skripkina – infectious diseases specialist of the infectious diseases department
Rostov-on-Don
Competing Interests:
Authors declares no conflict of interest
D. V. Sizyakin
City Hospital № 1 n.a. N.A. Semashko
Russian Federation
Competing Interests:
Russian Federation
Dmitry V. Sizyakin – Dr. Sci. (Med.), Prof., chief medical office
Rostov-on-Don
Competing Interests:
Authors declares no conflict of interest
E. A. Antonova
City Hospital № 1 n.a. N.A. Semashko
Russian Federation
Competing Interests:
Russian Federation
Elena A. Antonova – Head of the KDL
Rostov-on-Don
Competing Interests:
Authors declares no conflict of interest
References
1. Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Res. 2020;176:104742. https://doi.org/10.1016/j.antiviral.2020.104742
2. Wu C, Chen X, Cai Y, Xia J, Zhou X, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934-943. Erratum in: JAMA Intern Med. 2020;180(7):1031. https://doi.org/10.1001/jamainternmed.2020.0994.
3. Shi Y, Wang Y, Shao C, Huang J, Gan J, et al. COVID-19 infection: the perspectives on immune responses. Cell Death Differ. 2020;27(5):1451-1454. https://doi.org/10.1038/s41418-020-0530-3
4. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. https://doi.org/10.1056/NEJMoa2002032
5. Perico L, Benigni A, Casiraghi F, Ng LFP, Renia L, Remuzzi G. Immunity, endothelial injury and complement-induced coagulopathy in COVID-19. Nat Rev Nephrol. 2021;17(1):46-64. https://doi.org/10.1038/s41581-020-00357-4
6. Hu B, Huang S, Yin L. The cytokine storm and COVID-19. J Med Virol. 2021;93(1):250-256. https://doi.org/10.1002/jmv.26232
7. Zheng Y, Wang L, Ben S. Meta-analysis of chest CT features of patients with COVID-19 pneumonia. J Med Virol. 2021;93(1):241-249. https://doi.org/10.1002/jmv.26218
8. Skripkinа N.A., Sizyakinа L.P., Antonova E.A., Sizyakin D.V., Zakurskayа V.Y. Features of innate and adaptive immunity in patients with moderate course of COVID-19 with various degrees of lung tissue damage. Cytokines and inflammation. 2022;19(1-4):69-74. https://doi.org/10.17816/CI2022221-4-10
Review
For citations:
Skripkina N.A., Sizyakin D.V., Antonova E.A. Clinical and immunological characteristics of patients with moderate COVID-19 with different lung lesion areas. Medical Herald of the South of Russia. 2023;14(4):22-28. (In Russ.) https://doi.org/10.21886/2219-8075-2023-14-4-22-28
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