Analysis of Pregnancy, Labor and Perinatal Outcomes of Women with Pyelonephritis
Abstract
Purpose: Assessment of the impact of chronic pyelonephritis (CP) on pregnancy, childbirth and the state of a newborn.
Materials and Methods: 64 pregnant women with chronic pyelonephritis (study group). Comparison group consisted of 124 apparently healthy women with physiological pregnancy. In the groups evaluated parity, clinical and laboratory parameters of blood (blood count, hematocrit, leukocyte index of intoxication), during pregnancy, birth, state of the newborn babies and their incidence. To detect virus-bacterial pathogens persisting in the urine of infants born to mothers with HP, examined 42 children. All isolates were determined rates of adhesion and persistence factors (antilizotsim (ALA) and antiinterferon (AIA) activity). In the urine of surveyed defined mycoplasma, chlamydia, herpes simplex virus type I and II, Epstein-Barr virus, cytomegalovirus, and papilloma viruses using standard polymerase chain reaction (PCR).
Results: Pregnancy complicated by HP more severe with various complications: anemia and placental insufficiency. In patients with CP were significantly more marked prematurity (6,25% versus 1,6% in the comparison group). In assessing the viral-bacterial infection of the urine of infants born to mothers suffering from CP, 50% of the bacterial population was observed in 50% were identified opportunistic bacteria in an amount not to exceed thresholds.
Summary: Chronic pyelonephritis is one of the factors influencing the course of pregnancy. Perinatal morbidity in children born to women who suffer from CP, no more than general population values. Significant correlation between the microflora of mother and child is absent.
About the Authors
A. N. Rymashevsky
Rostov State Medical University
Russian Federation
Russian Federation
Department of Obstetrics and Gynecology № 1
29 Nakhichevansky st., Rostov-on-Don, 344022
A. E. Volkov
Rostov State Medical University
Russian Federation
Russian Federation
Department of Obstetrics and Gynecology № 1
29 Nakhichevansky st., Rostov-on-Don, 344022
J. L. Naboka
Rostov State Medical University
Russian Federation
Russian Federation
Microbiology and Virology Department №1
29 Nakhichevansky st., Rostov-on-Don, 344022
N. A. Krasnikova
Rostov State Medical University
Russian Federation
Russian Federation
Department of Obstetrics and Gynecology № 1
29 Nakhichevansky st., Rostov-on-Don, 344022
V. V. Markina
Rostov State Medical University
Russian Federation
Russian Federation
Department of Obstetrics and Gynecology № 1
29 Nakhichevansky st., Rostov-on-Don, 344022
References
1. Бабина М.Г. Особенности течения беременности, родов, состояния новорожденных у женщин с хроническим пиелонефритом: Дис. … канд. мед. наук.– М., 2003.– 151 с.
2. Hart A., Nowicki B.J., Reisner B. et al. Ampicillin-resistant Escherichia coli in gestational pyelonephritis: increased occurrence and association with the colonization factor Dr adhesin // J. Infect. Dis.– 2001.– V.183, №10.– P.1526-1529.
3. Дудукалов С. Г., Гайдукова Е.Г., Сиротина З. В. Влияние хронического пиелонефрита на формирование патологических изменений в плаценте // Дальневост. мед. журн.– 2000.– №1. C.13-16.
4. Качалина Т.С., Каткова Н.Ю., Николаева О.А. Клинические аспекты дифференцированного подхода к лечению и профилактике пиелонефрита у беременных // Consilium medicum.– 2004.– Т.6.- №6.– С.251-254.
5. Судакова Н.М. Клинические проявления поражений нервной системы у новорожденных, родившихся от матерей с хроническим пиелонефритом // Рос. пед. журн.- 2001.- №3.- С. 8-10.
6. Wing D.A. Pyelonephritis in pregnancy: treatment options for optimal outcomes // Drugs.– 2001.– V.61, № 14.– P.2087-2096.
7. Никольская И.Г., Тареева Т.Г., Микаелян А.В. и др. Пиелонефрит и беременность. Этиология, патогенез, классификация, клиническая картина, перинатальные осложнения // Росс. вестн. акушера-гинеколога.– 2003.– №2.– С. 34–36.
8. Roy K.K., Malhotra N., Banerjee K. Recurrent eclampsia in a woman with chronic pyelonephritis // Eur. J. Obstet. Gynecol. Reprod. Biol.– 2001.– V.94, № 2.– P.307-308.
9. Ишкабулова Г.Д. Особенности функционального состояния почек у новорожденных от матерей, больных хроническим пиелонефритом // Педиатрия.– 2001.- №3.– С.42-45.
10. Машковцева И.А., Астафьева А.Н. Клинико-бактериологические особенности уроренальной инфекции у детей раннего возраста // Ж. Педиатрия.- 1992.- №2.- С.105.
11. Бухарин О.В. Персистенция патогенных бактерий. М.- Медицина, 1999.- 366 с.
Review
For citations:
Rymashevsky A.N., Volkov A.E., Naboka J.L., Krasnikova N.A., Markina V.V. Analysis of Pregnancy, Labor and Perinatal Outcomes of Women with Pyelonephritis. Medical Herald of the South of Russia. 2011;(2):86-90. (In Russ.)
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