Prenatal Invasive Diagnosis with Quantitative Fluorescent PCR
Abstract
Purpose: To develop the method of prenatal invasive diagnosis and compare it abilities with traditional genetic cytological examination.
Materials and Methods: There was conducted prenatal fetal invasive diagnosis of 366 pregnant women. Depending on the pregnancy age and genetic indications the chorionic villus sampling, cordocentesis and amniocentesis were carried.
Results: The obtained samples was treated with QF-PCR and it results was verified by standard karyotyping. In all cases, the differences of the two methods was not observed.
Summary: It was shown the technique of quantitative fluorescent polymerase chain reaction (QF-PCR) has advantages over the standard cytologic examination and reduces analysis duration and increases the number of patients.
About the Authors
V. V. Avrutskaja
Rostov Scientific Research Institute of Obstetrics and Pediatrics
Russian Federation
Russian Federation
43 Mechnikova st., Rostov-on-Don, 344012
N. V. Kriventsova
Rostov Scientific Research Institute of Obstetrics and Pediatrics
Russian Federation
Russian Federation
43 Mechnikova st., Rostov-on-Don, 344012
R. A. Shokarev
Rostov Scientific Research Institute of Obstetrics and Pediatrics
Russian Federation
Russian Federation
43 Mechnikova st., Rostov-on-Don, 344012
V. S. Gimbut
Rostov Scientific Research Institute of Obstetrics and Pediatrics
Russian Federation
Russian Federation
43 Mechnikova st., Rostov-on-Don, 344012
S. Y. Kriger
Rostov Scientific Research Institute of Obstetrics and Pediatrics
Russian Federation
Russian Federation
43 Mechnikova st., Rostov-on-Don, 344012
References
1. Баранов В.С., Вахарловский В.Г. Наследственные болезни и дородовая диагностика. - С-Пб.: Знание., 2003. – 48 с.
2. Пренатальная диагностика наследственных и врожденных болезней / Под ред. Айламазяна Э.К., Баранова В.С. – М.: МЕДпресс-информ., 2006. – 384 с.
Review
For citations:
Avrutskaja V.V., Kriventsova N.V., Shokarev R.A., Gimbut V.S., Kriger S.Y. Prenatal Invasive Diagnosis with Quantitative Fluorescent PCR. Medical Herald of the South of Russia. 2011;(2):60-62. (In Russ.)
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