Proinflammatory cytokines in patients with acute myocardial infarction against the background of chronic obstructive pulmonary disease
https://doi.org/10.21886/2219-8075-2020-11-3-40-47
Abstract
Objective: To study and analyze serum levels of interleukins (IL): IL-1β, IL-2 and IL-6 in patients with myocardial infarction and chronic obstructive pulmonary disease.
Materials and methods: In 85 people were examined: 28 patients with myocardial infarction, 37 patients with comorbid pathology (myocardial infarction and chronic obstructive pulmonary disease) and 20 somatically healthy volunteers as a control group. Determination of IL-1β, IL-2 and IL-6 levels was basing on enzyme immunoassay.
Results: The median and inter-percentile range of IL-1β, IL-2 and IL-6 in the donors did not differ significantly from the data of the manufacturer. In the group of patients with myocardial infarction and in patients with comorbid pathology a statistically significant increase in the level of median and inter-percentile range of cytokines was revealing compared with the control group. The highest levels of IL-1β, IL-2 and IL-6 were detecting in the group of patients with comorbid pathology. IL-6 was found to be an independent marker of increased risk of STEMI and an increase in its concentration later than 12 hours after hospitalization is associated with the risk of future cardiovascular death or new myocardial infarction.
Conclusion: Analysis of the dynamics of the level of IL-1β, IL-2 and IL-6 has a high prognostic value in patients with myocardial infarction and in patients with comorbid pathology.
About the Authors
A. V. Naumov
Astrakhan State Medical University
Russian Federation
Russian Federation
Andrey V. Naumov, Post-graduate student of the Department of Internal Diseases of Pediatric Faculty
Astrakhan
T. V. Prokofieva
Astrakhan State Medical University
Russian Federation
Russian Federation
Tatyana V. Prokofieva, Cand. Sci. (Med.), Associate Professor of the Department of Internal Diseases of Pediatric Faculty
Astrakhan
O. S. Polunina
Astrakhan State Medical University
Russian Federation
Russian Federation
Olga S. Polunina, Dr. Sci. (Med.), Professor, Head of the Department of Internal Diseases of Pediatric Faculty
Astrakhan
L. V. Saroyants
Scientific research Institute for the study of leprosy
Russian Federation
Russian Federation
Lyudmila V. Saroyants, Dr. Sci. (Med.), head of the Laboratory and Experimental Department
Astrakhan
E. A. Polunina
Astrakhan State Medical University
Russian Federation
Russian Federation
Ekaterina A. Polunina, Dr. Sci. (Med.), Associate Professor of the Department of Internal Diseases of Pediatric Faculty
Astrakhan
References
1. Divo M, Cote C, de Torres JP, Casanova C, Marin JM, et al. Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;186:155–161. https://doi.org/10.1164/rccm.201201-0034OC
2. Vanfleteren LE, Spruit MA, Groenen M, Gaffron S, van Empel VP, et al. Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;187:728–735. https://doi.org/10.1164/rccm.201209-1665OC
3. Barnett K, Mercer SW, Norbury M, Watt GG, Wyke S, et al. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012;380:37–43. https://doi.org/10.1016/S0140-6736(12)60240-2
4. Andell P, Koul S, Martinsson A, Sundström J, Jernberg T, et al. Impact of chronic obstructive pulmonary disease on mor bidity and mortality after myocardial infarction. Open Heart. 2014;1:e000002. DOI:10.1136/openhrt-2013-000002
5. Brekke PH, Omland T, Smith P, Soyseth V. Underdiagnoses of myocardial infarction in COPD - Cardiac Infarction Injury Score (CIIS) in patients hospitalized for COPD exacerbation. Respir Med. 2008;102:1243–1247. https://doi.org/10.1016/j.rmed.2008.04.010
6. Morgan AD, Zakeri R, Quint JK. Defining the relationship between COPD and CVD: what are the implications for clinical practice? Ther. Respir. Dis. 2018;12:11–16. https://doi.org/10.1177/1753465817750524
7. Kunisaki KM, Dransfield MT, Anderson JA, Brook RD, Calverley PM, et al. Exacerbations of chronic obstructive pulmonary disease and cardiac events: a cohort analysis. Am J Respir Crit Care Med. 2018;198:51–557. https://doi.org/10.1164/rccm.201711-2239OC
8. Donaldson GC, Hurst JR, Smith CJ, Hubbard RB, Wedzicha JA. Increased risk of myocardial infarction and stroke following exacerbation of COPD. Chest. 2010;137:1091–1097. https://doi.org/10.1378/chest.09-2029
9. Linden F, Domschke G, Erbel C, Akhavanpoor M, Katus HA, Gleissner CA. Inflammatory therapeutic targets in coronary atherosclerosis-from molecular biology to clinical application. Front Physiol. 2014;5:P. 455. https://doi.org/10.3389/fphys.2014.00455
10. Van Eeden S., Leipsic J., Paul Man S.F., Sin D.D. The relationship between lung inflammation and cardiovascular disease. Am J Respir Crit Care Med. 2012;186(1):11–16. https://doi.org/10.1164/rccm.201203-0455PP
11. Roversi S, Roversi P, Spadafora G, Rossi R, Fabbri LM. Coronary artery disease concomitant with chronic obstructive pulmonary disease. Eur J Clin Invest. 2014;44:93–102. https://doi.org/10.1111/eci.12181
12. Dinarello CA. Interleukin 1b and interleukin 18 as mediators of inflammation and the aging process. Am.J.Clin. Nutr. 2006;83(2):4447-455. https://doi.org/10.1093/ajcn/83.2.447s
13. Chen BB, Li ZH, Gao S. Circulating miR-146a/b correlates with inflammatory cytokines in COPD and could predict the risk of acute exacerbation COPD. Medicine (Baltimore). 2018;97(7):e9820. https://doi.org/10.1097/MD.0000000000009820
14. Min X, Lu M, Tu S, Wang X, Pang S, et al. Serum cytokine profile in relation to the severity of coronary artery disease Biomed Research international. 2017;2017:4013685. https://doi.org/10.1155/2017/4013685
15. Simon AD, Yazdani S, Wang W, Schwartz A, Rabbani LE. Elevated plasma levels of interleukin-2 and soluble IL-2 receptor in ischemic heart disease. Clin Cardiol. 2001;24(3):253-256. https://doi.org/10.1002/clc.4960240315
16. Han SF, Li XY, Liu KW, Wang L, Cui R, et al. Imbalance of T helper 1 cells/T helper 2 cells accelerated T-cell-mediated endothelium injury in patients with acute coronary syndromes. Zhonghua Xin Xue Guan Bing Za Zhi. 2008;36(12):1070– 1073. PMID: 19134272 (in Chinese)
17. Barczyk A, Pierzchała W, Kon OM, Cosio B, Adcock IM, et al. Cytokine production by bronchoalveolar lavage T lymphocytes in chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2006;117(11):1484-1492. https://doi.org/10.1016/j.jaci.2006.02.013
18. Luc G, Bard JM, Juhan-Vague I, Ferrieres J, Evans A, et al. C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: The PRIME study. Arterioscler Thromb Vasc Biol. 2003;23:1255-1261. https://doi.org/10.1161/01.atv.0000079512.66448.1d
19. Shalenkova M.A., Mikhailova Z.D., Manyukova E.T., Basalgina T.A., Shishkina A.P. Levels of interleukins and melatonin in patients with acute coronary syndrome. Meditsinskaya immunologiya. 2014;16(5):473-480. (in Russ.) https://doi.org/10.15789/1563-0625-2017-2-191-196
20. Vitkina T.I., Denisenko Yu.K., Sidletskaya K.A. Changes in IL-6 receptor expression on the surface of immunocompetent cells in the progression of chronic obstructive pulmonary disease. Meditsinskaya immunologiya. 2017;19(2):191-196. (In Russ.) https://doi.org/10.15789/1563-0625-2017-2-191-196.
21. Passoni F, Morelli B, Seveso G, Lazzati L, Beria G, et al. Comparaitive short-term prognostic value of hemostatic and inflammatoery markers in patients with non-ST elevation acute coronary syndrome. Ital. Heart J. 2002;3(1):28-35. PMID: 11899586
22. Polikutina O.M., Slepynina Yu.S., Bazdyrev E.D., Karetnikova V.N., Barbarash O.L. Outcomes of St-segment elevation myocardial infarction in patients with chronic obstructive pulmonary disease in the Kemerovo region. Rossiiskii Kardiologicheskii Zhurnal. 2014; 7(111):91-97. (In Russ.) https://doi.org/10.15829/1560-4071-2014-7-91-97
23. Ozdemir O, Gundogdu F, Karakelleoglu S, Sevimli S, Pirim I, et al. Comparison of serum levels of inflammatory markers and allelic variant of interleukin-6 in patients with acute coronary syndrome and stable angina pectoris. Coron Artery Dis. 2008;19:15–19. https://doi.org/10.1097/mca.0b013e3282f27bf7
24. Kilic T. Relation between proinflammatory to anti-inflammatory cytokine ratios and long-term prognosis in patients with non-ST elevation acute coronary syndrome. Heart. 2006;92:1041–1046. https://doi.org/10.1136/hrt.2005.080382
25. Dizdarević-Hudić L, Kušljugić Z, Baraković F, Brkić S, Sabitović D, et al. Correlation between interleukin 6 and interleukin 10 in acute myocardial infarction. Bosn J Basic Med Sci. 2009;9(4):301–306. https://doi.org/10.17305/bjbms.2009.2784
26. Groot HE, Al Ali L, van der Horst ICC, Schurer RAJ, van der Werf HW, et al Plasma interleukin 6 levels are associated with cardiac function after ST-elevation myocardial infarction. Clinical Research in Cardiology. 2018;108:612-621. https://doi.org/10.1007/s00392-018-1387-z
27. Bennermoa M, Held C, Green F, Strandberg L-E, Ericsson C-G, et al. Prognostic value of plasma interleukin-6 concentrations and the −174 G > C and −572 G > C promoter polymorphisms of the interleukin-6 gene in patients with acute myocardial infarction treated with thrombolysis. Atherosclerosis May. 2004;174(1):157–163. https://doi.org/10.1016/j.atherosclerosis.2004.01.019
28. Alyavi A.L., Nizomov A.A., Kasimova G.M. Clinical and diagnostic significance of cytokine activation and the possibility of correcting disorders in patients with acute coronary syndrome with St segment elevation. Tezisy Rossiiskogo natsional'nogo kongressa kardiologov. – 2012. - №0024. - S. 43-44. (In Russ.)
Review
For citations:
Naumov A.V., Prokofieva T.V., Polunina O.S., Saroyants L.V., Polunina E.A. Proinflammatory cytokines in patients with acute myocardial infarction against the background of chronic obstructive pulmonary disease. Medical Herald of the South of Russia. 2020;11(3):40-47. (In Russ.) https://doi.org/10.21886/2219-8075-2020-11-3-40-47
Views:
1002
Email this article 