A feature of the microbiota of the colon in patients with different phenotypes of obesity (pilot study)
https://doi.org/10.21886/2219-8075-2020-11-2-38-45
Abstract
Purpose: to study the microbiota of the colon in patients with various types of obesity and in healthy people.
Materials and methods: 37 people were examined (average age 39.6 ± 4.2 years) for the period 2018 – 2019. Formed 3 clinical groups. I group (n = 11) — healthy people with normal body weight (control), II group (n = 13) — patients with metabolically healthy obesity (MHO), III group (n = 13) — with obesity and metabolic disorders. In all patients, the basic metabolic parameters were studied and a quantitative assessment of the state of colon microbiocenosis was performed.
Results: compared to the formal-normative quantitative indicators, the examined fecal groups I, II and III showed unidirectional changes characterized by a decrease (p < 0.05) of Lactobacillus spp., Bifi dobacterium spp., B. thetaiotaomicron and an increase (p < 0.05 ) Enterobacter spp. / Citrobacter spp. Colon microbiota changes in groups II and III are characterized by the appearance of Proteus spp. and Klebsiella spp. (9.1 % and 8.3 % respectively). C. diffi cile (8.3 %) was detected in feces only in group III and the frequency of detection of banal E. coli was increased. Th e amount of F. prausnitzii was reduced (p < 0.05) in group III compared with group 1.
Conclusion: the data obtained as a result of a pilot study indicate changes in the microbiota of the colon in people with diff erent phenotypes of obesity.
About the Authors
N. I. Volkova
Rostov State Medical University
Russian Federation
Russian Federation
Natalia I. Volkova, Dr. Sci. (Med.), Professor, head of Department of internal medicine №3
Rostov-on-Don
Y. L. Naboka
Rostov State Medical University
Russian Federation
Russian Federation
Yulia L. Naboka, Dr. Sci. (Med.), Professor, head of Department of microbiology and virology №1
Rostov-on-Don
L. A. Ganenko
Rostov State Medical University
Russian Federation
Russian Federation
Liliya A. Ganenko, assistant of the Department of internal medicine №3
Rostov-on-Don
O. S. Оksenuk
Rostov State Medical University
Russian Federation
Russian Federation
Oksana S. Оksenuk, Head of the Central Research Laboratory
Rostov-on-Don
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Review
For citations:
Volkova N.I., Naboka Y.L., Ganenko L.A., Оksenuk O.S. A feature of the microbiota of the colon in patients with different phenotypes of obesity (pilot study). Medical Herald of the South of Russia. 2020;11(2):38-45. (In Russ.) https://doi.org/10.21886/2219-8075-2020-11-2-38-45
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