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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2219-8075-2019-10-2-71-76</article-id><article-id custom-type="elpub" pub-id-type="custom">mvjr-864</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБМЕН ОПЫТОМ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXPERIENCE EXCHANGE</subject></subj-group></article-categories><title-group><article-title>Экспериментальный метод замещения костно-хрящевых дефектов суставов (ранние результаты)</article-title><trans-title-group xml:lang="en"><trans-title>Experimental method replacement of the osteo-chondral defects of the large joints (first results)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7507-7772</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Айрапетов</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Airapetov</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Георгий Александрович Айрапетов - кандидат медицинских наук, доцент кафедры травматологии и ортопедии</p></bio><bio xml:lang="en"><p>Georgii A. Airapetov - PhD, docent of department of traumatology and orthopedics</p></bio><email xlink:type="simple">AirapetovGA@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Загородний</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagorodniy</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Николай Васильевич Загородний - член-корреспондент РАН, заведующий кафедрой травматологии и ортопедии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Nikolay V. Zagorodniy - head ofdepartment oftraumatology and orthopedics.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воротников</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorotnikov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александр Анатольевич Воротников - заведующий кафедрой травматологии и ортопедии с курсом ДПО</p></bio><bio xml:lang="en"><p>Alexandr A. Vorotnikov - head of department of traumatology               and orthopedics</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ставропольский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Stavropol State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский университет дружбы народов</institution><country>Россия</country></aff><aff xml:lang="en"><institution>RUDN University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>02</day><month>09</month><year>2019</year></pub-date><volume>10</volume><issue>2</issue><fpage>71</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Айрапетов Г.А., Загородний Н.В., Воротников А.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Айрапетов Г.А., Загородний Н.В., Воротников А.А.</copyright-holder><copyright-holder xml:lang="en">Airapetov G.A., Zagorodniy N.V., Vorotnikov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/864">https://www.medicalherald.ru/jour/article/view/864</self-uri><abstract><sec><title>Цель</title><p>Цель: разработать и предложить оригинальный метод лечения костно-хрящевых дефектов гиалинового хряща на примере коленного сустава.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы: проспективное исследование проводилось на экспериментальных животных (овцы) в количестве 30 особей, возраст которых составил от 1 года до 3.5 лет, вес от 18 до 28 кг. Все особи разделены на 3 репрезентативные группы по 10 особей в зависимости от метода восполнения дефекта сустава. Во всех группах выполнялся полнослойный дефект гиалинового хряща с захватом поверхностной части субхондральной кости диаметром 4.5 мм по внутренней поверхности мыщелка бедра, несущей нагрузку и замещался различными способами. Выделенные костно-хрящевые фрагменты исследовали визуально, оценивая характер краёв дефекта суставного хряща, состояние его кровенаполнения, глубину дефекта, степень закрытия дефекта формирующимся фибрознохрящевым слоем. Область дефекта субхондральной пластинки изучали морфологически с использованием световой микроскопии.</p></sec><sec><title>Результаты</title><p>Результаты: результаты в группе без замещения дефекта сопоставимы с аналогичными исследованиями других авторов, что свидетельствует о невозможности организма самостоятельно восполнить имеющийся костнохрящевой дефект. Наилучшие результаты показаны в третьей группе, где костно-хрящевой дефект практически полностью заместился макроскопически, а микроскопически удалось проследить архитектонику новообразованной гиалиновоподобной ткани, что свидетельствует о хороших ранних результатах применения описываемой методики.</p></sec><sec><title>Выводы</title><p>Выводы: Предложенный оригинальный метод лечения костно-хрящевых дефектов коленного сустава позволил получить хорошие результат в ранние сроки. Необходимо дальнейшее наблюдение за поведением регенерата во всех экспериментальных группах.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: to develop and offer an original method of treatment of bone and cartilage defects of hyaline cartilage on the example of the knee joint.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods: a prospective study conducted on experimental animals (sheep) in an amount of 30 individuals, whose age was from 1.5 to 3 years, weight was from 20 to 30 kg. All individuals divided into 3 representative groups of 10 individuals, depending on the method of replenishment of the joint defect. In all groups, a full-thickness defect of the articular cartilage performed to a subchondral bone 4.5 mm in diameter on the loaded surface of the inner condyle of the thigh. Distinct bone-cartilage fragments examined visually, evaluating the nature of the edges of the articular cartilage defect, the condition of its blood filling, the depth of the defect, the degree of closure of the defect by the emerging fibrous-cartilaginous layer. The area of the defect of the subchondral plate studied morphologically using light microscopy.</p></sec><sec><title>Results</title><p>Results: The best results are shown in group 3, where the bone-cartilaginous defects are practically fully replaced macroscopically and microscopically managed to trace the architectonics of the newly formed hyaline-like tissue, which indicates good early results of the application of the described method.</p></sec><sec><title>Conclusions</title><p>Conclusions: the proposed original method of treatment of bone and cartilage defects of the knee joint allowed to get good results in the early stages. It is necessary to further observe the behavior of the regenerate in all experimental groups.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>костно-хрящевой дефект</kwd><kwd>мембрана для регенерации</kwd><kwd>эксперимент</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteo-chondral defects</kwd><kwd>membrane for regeneration</kwd><kwd>experiment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Божокин М.С., Божкова С.А., Нетылько Г.И. Возможности современных клеточных технологий для восстановления поврежденого суставного хряща (аналитический обзор литературы). // Травматология и ортопедия России. - 2016ю - Т.22, №3. - С.122-134. doi: 10.21823/2311-2905-2016-22-3-122-134</mixed-citation><mixed-citation xml:lang="en">Bozhokin MS, Bozhkova SA, Netylko GI. Possibilities of current cellular technologies for articular cartilage repair (analytical review). 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