mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2018-9-3-17-28mvjr-696Research ArticleОБЗОРЫREVIEWСтратификация факторов риска развития тромбоэмболических осложнений у пациентов травматолого-ортопедического профиляStratification of deep vein thrombosis and pulmonary embolism risk factors after trauma and orthopedic surgeryhttps://orcid.org/0000-0001-7107-2691ГолубевГ. Ш.GolubevG. Sh.

Голубев Георгий Шотавич, д.м.н., профессор, заведующий кафедрой травматологии и ортопедии, ЛФК и спортивной медицины ФПК и ППС

Georgiy S. Golubev, PhD, prof., head of the Department of Traumatology and Orthopedics, Physical Fitness and Sports Medicine

ortho-rostgmu@yandex.ruhttps://orcid.org/0000-0002-9637-8950СаськоС. С.SaskoS. S.

Сасько Сергей Сергеевич, аспирант кафедры травматологии и ортопедии, ЛФК и спортивной медицины ФПК и ППС

Sergey S. Sasko, graduate student, Department of Traumatology and Orthopedics, Physical Fitness and Sports Medicine

sergej-sasko@yandex.ruhttps://orcid.org/0000-0002-4349-5897БачуринС. С.BachurinS. S.

Бачурин Станислав Сергеевич, ассистент кафедры фармацевтической химии и фармакогнозии

Stanislav S. Bachurin, assistant, Department of pharmaceutical chemistry and pharmacognosy

bachurin.rostgmu@gmail.comhttps://orcid.org/0000-0001-8767-8639БерезовскийД. П.BerezovskiyD. P.

Березовский Дмитрий Павлович, д.м.н., доцент, заведующий кафедрой судебной медицины

Dmitry P. Berezovsky, PhD, assistant professor, head of the Department of forensic medicine

dpb@mail.ruРостовский государственный медицинский университет, Ростов-на-ДонуРоссияRostov State Medical University, Rostov-on-DonRussian Federation201801102018931728Copyright © Голубев Г.Ш., Сасько С.С., Бачурин С.С., Березовский Д.П., 20182018Голубев Г.Ш., Сасько С.С., Бачурин С.С., Березовский Д.П.Golubev G.S., Sasko S.S., Bachurin S.S., Berezovskiy D.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/696

Цель настоящей работы — оценка способов стратификации риска тромбоза глубоких вен (ТГВ) и тромбоэмболии лёгочной артерии (ТЭЛА) после оперативного вмешательства у пациентов травматолого-ортопедического профиля. Литературные данные о роли факторов риска, в особенности генетических, в развитии послеоперационных тромбоэмболических осложнений носят разрозненный характер. В обзоре проанализирована частота встречаемости тромботических осложнений у пациентов травматолого-ортопедического профиля. Проведен анализ моделей стратификации риска ТГВ и ТЭЛА. На основе литературных данных показано, что никакая единственная мутация или полиморфизм известных генов не являются достаточно значимыми для клинической стратификации риска. Корреляционный анализ комбинаций полиморфизма или мутации нескольких генов повышают вероятность правильной оценки риска. Предложена программная версия калькуляторов риска венозных-тромбоэмболических осложнений и кровотечений в периоперационном периде.

The aim of this work is to assess the methods of risk stratification of deep vein thrombosis (DVT) and pulmonary embolism (PE) after trauma and orthopedic surgery. Modern data devoted to risk factors of DVT and PE (including genetic) are uncertaint. We analyzed probability of DVT and PE on the base of literature data for trauma and orthopedic patients. Different models of risk stratification being compared. Single gene mutation is not sig-nificant for DVT risk prediction. Correlations between several gene mutations and polymorphism increase probability of proper risk estimation. Programmatic DVT and HAS risk estimation calculator developed and is accessible on web-site.

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The authors declare that there are no conflicts of interest present.