mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2018-9-1-70-79mvjr-661Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESИнформативность маркеров системного воспаления у пациентов со стабильной ишемической болезнью сердца: влияние симптомов депрессии и рестеноза в анамнезеInformativeness of markers of systemic inflammation in patients with stable ischemic heart disease: influence of depressive symptoms and restenosis in anamnesisОреховаЮ. Н.OrekhovaI. N.

аспирант кафедры терапии ФПК и ППС РостГМУ

postgraduate student

orehowa.yulia@yandex.ruИванченкоД. Н.IvanchenkoD. N.

к.м.н., ассистент кафедры терапии ФПК и ППС

PhD, assistant

d_ivanchenko@mail.ruДорофееваН. П.DorofeevaN. P.

д.м.н., профессор кафедры терапии ФПК и ППС

PhD, professor

ppmahogany@yandex.ruМартиросовВ. Ю.MartirosovV. Y.

к.м.н., ассистент кафедры организации здравоохранения и общественного здоровья с курсом информационных компьютерных технологий в здравоохранении и медицине ФПК и ППС

PhD, assistant

ШлыкС. В.ShlykS. V.

д.м.н., профессор, заведующий кафедрой терапии ФПК и ППС

PhD, professor

Ростовский Государственный Медицинский УниверситетРоссияRostov State Medical University, Rostov-on-DonRussian FederationРостовский государственный медицинский университет, Ростов-на-ДонуРоссияRostov State Medical University, Rostov-on-DonRussian Federation201823032018917079Copyright © Орехова Ю.Н., Иванченко Д.Н., Дорофеева Н.П., Мартиросов В.Ю., Шлык С.В., 20182018Орехова Ю.Н., Иванченко Д.Н., Дорофеева Н.П., Мартиросов В.Ю., Шлык С.В.Orekhova I.N., Ivanchenko D.N., Dorofeeva N.P., Martirosov V.Y., Shlyk S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/661Цель

Цель: изучить лабораторные маркеры воспаления у пациентов со стабильной ИБС, оценить взаимосвязь интенсивности системного воспаления с симптомами депрессии.

Материалы и методы: В исследование были включены 46 мужчин в возрасте от 46 до 75 лет, госпитализированных с целью консервативного (n =20) и хирургического (чрескожное коронарное вмешательство (ЧКВ) со стентированием, n = 26) лечения ИБС. В качестве маркеров воспаления оценивались абсолютное количество лейкоцитов и нейтрофилов, рассчитывались показатели отношения количества моноцитов к уровню липопротеидов высокой плотности (ЛПВП), а также абсолютного числа нейтрофилов к лимфоцитам. Проводилась оценка выраженности симптомов тревоги и депрессии (использовалась анкета CES-D).Результаты: Симптомы депрессии различной степени тяжести были обнаружены у 8 пациентов (17,37% от общего числа). Отношение количества моноцитов к уровню ЛПВП у пациентов с ИБС было значимо выше по сравнению со здоровыми лицами; при наличии симптомов депрессии, ранее имплантированным стентом, рестенозом стента в анамнезе  отмечалось еще более значимое увеличение показателя. Уровень лейкоцитов был выше в ранний период после перенесенного ЧКВ со стентрованием и у лиц с рестенозом стента в анамнезе. Уровень нейтрофилов и отношение нейтрофилов к лимфоцитам оказался значимо выше у лиц с симптомами депрессии, в ранний послеоперационный период, а также с перенесенным ранее рестенозом стента.Заключение: уровень системного воспаления, оцениваемый при помощи рутинных лабораторных показателей, был значимо выше как у лиц с неблагоприятным анамнезом ИБС, так и при сопутствующих симптомах депрессивного расстройства

Objective

Objective: the aim of the study was to investigate laboratory markers of inflammation in patients with stable ischemic heart disease, to estimate their interrelation with symptoms of depression. Matherials and methods: 46 men aged from 46 to 75 years hospitalized for the conservative (n = 20) and surgical (n = 26) treatment of ischemic heart disease participated in the study. An evaluation of inflammatory markers (absolute quantity of leukocytes and neutrophils, monocyte/HDL ratio and neutrophil/lymphocyte ratio) was performed. Depressive symptoms were measured using the CES-D scale. Conclusions: symptoms of depression were found in 8 patients (17,37%). 13% of them had symptoms of mild depression, 4,37% - symptoms of severe depression. The monocyte/HDL ratio was significantly higher in patients with ischemic heart disease comparing to healthy individuals. The monocyte/HDL ratio was significantly increased in patients with depressive symptoms, previously implanted stent, restenosis of the coronary stent in anamnesis. Level of leukocytes was higher during the early period after the procedure of percutaneous coronary intervention with stenting and in patients with stent restenosis. Number of neutrophils and the neutrophil/lymphocyte ratio were significantly higher in patients with depression symptoms, during the early period after stent implantation and also with previous restenosis of the stent. Systemic inflammation estimated using routine laboratory tests was significantly higher in both patients with complicated ischemic heart disease, and with symptoms of depressive disorder. Routine laboratory indicators can be informative in assessing inflammation in patients with ischemic heart disease. Symptoms of depression and stent restenosis can be followed by increased inflammatory markers.

 

 

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The authors declare that there are no conflicts of interest present.