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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2219-8075-2017-8-3-6-16</article-id><article-id custom-type="elpub" pub-id-type="custom">mvjr-600</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>МЕТАБОЛИЧЕСКИ ЗДОРОВОЕ ОЖИРЕНИЕ — ЧТО МЫ О НЕМ ЗНАЕМ?</article-title><trans-title-group xml:lang="en"><trans-title>METABOLIC HEALTHY OBESITY, WHAT DO WE KNOW ABOUT IT?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4874-7835</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Волкова</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Volkova</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Волкова Наталья Ивановна – доктор медицинских наук, профессор, проректор по научной работе </p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Natalya I. Volkova – M.D., Ph.D., professor of medicine, vice rector for scientific work, chief of the department of Internal Diseases III</p><p>Rostov-on-Don</p></bio><email xlink:type="simple">n_i_volkova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ганенко</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ganenko</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ганенко Лилия Александровна – врач-эндокринолог терапевтического отделения № 2 </p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Lilya A. Ganenko – M.D., endocrinologist, Therapeutic Department 2 </p><p>Rostov-on-Don</p></bio><email xlink:type="simple">ganenko.lilia@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поркшеян</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Porksheyan</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Поркшеян Мария Игоревна – кандидат медицинских наук, доцент кафедры внутренних болезней № 3 </p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Mariya I. Porksheyan – M.D., Ph.D., Associate professor, department of Internal Diseases III </p><p>Rostov-on-Don</p></bio><email xlink:type="simple">Porksheyan_mi@rostgmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ростовский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2017</year></pub-date><volume>8</volume><issue>3</issue><fpage>6</fpage><lpage>16</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Волкова Н.И., Ганенко Л.А., Поркшеян М.И., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Волкова Н.И., Ганенко Л.А., Поркшеян М.И.</copyright-holder><copyright-holder xml:lang="en">Volkova N.I., Ganenko L.A., Porksheyan M.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/600">https://www.medicalherald.ru/jour/article/view/600</self-uri><abstract><p>Распространенность ожирения растет во всем мире. Ожирение является важным фактором риска сердечно-сосудистых заболеваний, сахарного диабета 2 типа. Однако не все пациенты с ожирением имеют неблагоприятный кардиометаболический профиль. В последнее время большое внимание уделяется концепции «метаболически здорового ожирения» (МЗО). На сегодняшний день нет единых критериев для идентификации лиц с МЗО, что затрудняет изучение этой подгруппы пациентов и проведения сравнительного анализа различных исследований. В статье представлены данные современной литературы, включающие определение, распространенность и механизмы развития МЗО, также обсуждаются потенциально протективные факторы, участвующие в развитии МЗО и последствия терапевтического воздействия на МЗО.</p></abstract><trans-abstract xml:lang="en"><p>The prevalence of obesity is growing all over the world. Obesity is an important risk factor for cardiovascular diseases, type 2 diabetes. However, not all obese patients have an unfavorable cardio-metabolic profile. Recently, much attention has been paid to the concept of «metabolically healthy obesity» (MHO). To date, there are no single criteria for identifying individuals with MHO, which makes it difficult to study this subgroup of patients and to conduct a comparative analysis of various studies. The article presents data of modern literature, including the definition, prevalence and mechanisms of MHO development, also discusses potentially protective factors involved in MHO development and the consequences of the therapeutic impact on MHO.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>обзор</kwd><kwd>метаболически здоровое ожирение</kwd><kwd>кардиометаболический риск</kwd><kwd>распределение жировой ткани</kwd><kwd>воспаление</kwd><kwd>прогноз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>review</kwd><kwd>metabolically healthy obesity</kwd><kwd>cardiometabolic risk</kwd><kwd>fat distribution</kwd><kwd>inflammation</kwd><kwd>forecast</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Non-Communicable Disease Risk Factor Collaboration. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants. // Lancet. – 2016. – V.387(10026). – P.1377–1396. doi: 10.1016/S0140-6736(16)30054-X</mixed-citation><mixed-citation xml:lang="en">Non-Communicable Disease Risk Factor Collaboration.  Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants.  La ncet.2016;387(10026):1377–1396. doi: 10.1016/S0140-6736(16)30054-X</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kelly T., Yang W., Chen C.S., Reynolds K., He J. Global burden of obesity in 2005 and projections to 2030. // Int J Obes (Lond). – 2008. – V.32. – P.1431-1437. doi: 10.1038/ijo.2008.102</mixed-citation><mixed-citation xml:lang="en">Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond). 2008;32:1431-1437. doi: 10.1038/ijo.2008.102</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Keane E., Kearney P.M., Perry I.J., Kelleher C.C., Harrington J.M.. Trends and prevalence of overweight and obesity in primary school aged children in the Republic of Ireland from 2002–2012: a systematic review. // BMC Public Health. – 2014. – V.14.P.974. doi: 10.1186/1471-2458-14-974</mixed-citation><mixed-citation xml:lang="en">Keane E,  Kearney PM,  Perry IJ, Kelleher CC, Harrington JM.  Trends and prevalence of overweight and obesity in primary school aged children in the Republic of Ireland from 2002–2012: a systematic review. BMC Public Health. 2014;14:974. doi: 10.1186/1471-2458-14-974</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Primeau V., Coderre L., Karelis A.D., Brochu M., Lavoie M.E., Messier V., et al. Characterizing the profile of obese patients who are metabolically healthy. // Int J Obes (Lond). – 2011. – V.35(7). – P.971-81. doi: 10.1038/ijo.2010.216</mixed-citation><mixed-citation xml:lang="en">Primeau V,  Coderre L,  Karelis AD,  Brochu M,  Lavoie ME,  Messier V,  et al. Characterizing the profile of obese patients who are metabolically healthy. Int J Obes (Lond). 2011;35(7):971-81. doi: 10.1038/ijo.2010.216</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Jung C.H., Lee W.J., Song K.H. Metabolically healthy obesity: a friend or foe? // Korean J Intern Med. – 2017. – V.32(4). – P.611-621. doi: 10.3904/kjim.2016.259</mixed-citation><mixed-citation xml:lang="en">Jung CH, Lee WJ, Song KH. Metabolically healthy obesity: a friend or foe? Korean J Intern Med. 2017;32(4):611-621. doi: 10.3904/kjim.2016.259</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Karelis, A. Metabolically healthy but obese individuals. // Lancet. – 2008. V.372(9646). – P.1281–1283. doi: 10.1016/S0140-6736(08)61531-7.</mixed-citation><mixed-citation xml:lang="en">Karelis A. Metabolically healthy but obese individuals. Lancet. 2008;372(9646):1281–1283. doi: 10.1016/S01406736(08)61531-7.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Wildman R.P., Muntner P., Reynolds K., McGinn A.P., Rajpathak S., Wylie-Rosett J., et al. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). // Arch Intern Med. – 2008. – V.168 (15). – P.1617-1624. doi:10.1001/ar</mixed-citation><mixed-citation xml:lang="en">Wildman RP, Muntner P, Reynolds K, McGinn AP, Rajpathak S, Wylie-Rosett J, et al. The obese without cardiometabolic risk factor clustering and the normal weight with cardio-metabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med. 2008;168 (15):1617-1624. doi:10.1001/ar</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Roberson L.; Aneni E.; Maziak W., Agatston A., Feldman T.; RouseffM., et al. Beyond BMI: The “Metabolically healthy obese” phenotype &amp; its association with clinical/subclinical cardiovascular disease and all-cause mortality-A systematic review. // BMC Public Health – 2014. – V.14. – P.1–12.</mixed-citation><mixed-citation xml:lang="en">Roberson L, Aneni E, Maziak W, Agatston A, Feldman T; RouseffM, et al. Beyond BMI: The “Metabolically healthy obese” phenotype &amp; its association with clinical/subclinical cardiovascular disease and all-cause mortality-A systematic review. BMC Public Health 2014;14:1–12.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Van Vliet-Ostaptchouk J.; Nuotio M.; Slagter S.; Doiron D.; Fischer K., Foco L.; et al. The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: A collaborative analysis of ten large cohort studies. // BMC Endocr. Disord. – 2014. – V.14. – P. 9–22. doi: 10.1186/1472-6823-14-9</mixed-citation><mixed-citation xml:lang="en">Van Vliet-Ostaptchouk J, Nuotio M, Slagter S, Doiron D, Fischer K, Foco L, et al. The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: A collaborative analysis of ten large cohort studies. BMC Endocr. Disord. 2014;14:9–22. doi: 10.1186/1472-6823-14-9</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips C.M. Metabolically healthy obesity across the life course: epidemiology, determinants, and implications. // Ann N Y Acad Sci. – 2017. – V.1391 (1). – P.85-100. Doi:1111/nyas.13230.</mixed-citation><mixed-citation xml:lang="en">Phillips CM. Metabolically healthy obesity across the life course: epidemiology, determinants, and implications. Ann N Y Acad Sci. 2017;1391(1):85-100. doi: 1111/nyas.13230.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Karelis A.; Rabasa-Lhoret R. Obesity: Can inflammatory status define metabolic health? // Nat. Rev. Endocrinol. – 2013. – V.9 (12). – P.694–695. doi: 10.1038/nrendo.2013.198</mixed-citation><mixed-citation xml:lang="en">Karelis A, Rabasa-Lhoret R. Obesity: Can inflammatory status define metabolic health? Nat. Rev. Endocrinol. 2013;9(12):694–695. doi: 10.1038/nrendo.2013.198</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Stefan N.; Kantartzis K.; Machann J.; Schick F.; Thamer C.; Rittig K. et al. Identification and characterization of metabolically benign obesity in humans. // Arch. Intern. Med. – 2008. – V. 168(15). – P. 1609–1616. doi: 10.1001/archinte.168.15.1609</mixed-citation><mixed-citation xml:lang="en">Stefan N, Kantartzis K, Machann J, Schick F, Th amer C, Rittig K, et al. Identification and characterization of metabolically benign obesity in humans. Arch. Intern. Med. 2008;168(15):1609–1616. doi: 10.1001/archinte.168.15.1609</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips CM , Dillon C., Harrington JM, McCarthy V.J., Kearney P.M., Fitzgerald A.P., et al . Defining metabolically healthy obesity: role of dietary and lifestyle factors. // PLoS One. – 2013. – V.8 (10). – P. e76188. doi:10.1371/journal.pone.0076188</mixed-citation><mixed-citation xml:lang="en">Phillips CM,  Dillon  C,  Harrington  JM,   McCarthy VJ, Kearney PM, Fitzgerald AP, et al  . Defining metabolically healthy obesity: role of dietary and lifestyle factors. PLoS One. 2013;8(10):e76188. doi:10.1371/journal.pone.0076188</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Yoo H.K., Choi E.Y., Park E.W., Cheong Y.S., Bae R.A. Comparison of metabolic characteristics of metabolically healthy but obese (MHO) middle-aged men according to different criteria. // Korean J. Fam. Med. – 2013. – V.34(1). – P.19-26. doi: 10.4082/kjfm.2013.34.1.19</mixed-citation><mixed-citation xml:lang="en">Yoo HK, Choi EY, Park EW, Cheong YS, Bae RA. Comparison of metabolic characteristics of metabolically healthy but obese (MHO) middle-aged men according to different criteria. Korean J. Fam. Med. 2013;34(1):19-26. doi: 10.4082/kjfm.2013.34.1.19</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Velho S., Paccaud F., Waeber G., Vollenweider P., MarquesVidal P. Metabolically healthy obesity: different prevalences using different criteria. // Eur. J. Clin. Nutr. – 2010. – V. 64 (10). – P.1043–1051. doi: 10.1038/ejcn.2010.114</mixed-citation><mixed-citation xml:lang="en">Velho S,  Paccaud F,  Waeber G,  Vollenweider P, MarquesVidal P. Metabolically healthy obesity: different prevalences using different criteria. Eur. J. Clin. Nutr. 2010;64(10):1043– 1051. doi: 10.1038/ejcn.2010.114</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips C.M. Metabolically healthy obesity across the life course: epidemiology, determinants, and implications. // Ann N Y Acad Sci. – 2017. – V.139(1). – P.85-100. doi: 10.1111/nyas.13230</mixed-citation><mixed-citation xml:lang="en">Phillips CM. Metabolically healthy obesity across the life course: epidemiology, determinants, and implications. Ann N Y Acad Sci. 2017;139(1):85-100. doi: 10.1111/nyas.13230</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Arsenault B.J., Lachance D., Lemieux I., Alméras N., Tremblay A., Bouchard C. et al. Visceral adipose tissue accumulation, cardiorespiratory fitness, and features of the metabolic syndrome. // Arch Intern Med. – 2007. – V.167(14). – P.15181520. doi: 10.1001/archinte.167.14.1518</mixed-citation><mixed-citation xml:lang="en">Arsenault BJ, Lachance D, Lemieux I, Alméras N, Tremblay A, Bouchard C et al. Visceral adipose tissue accumulation, cardiorespiratory fitness, and features of the metabolic syndrome. Arch Intern Med. 2007;167(14):1518-1520. doi: 10.1001/archinte.167.14.1518</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Després J.P., Lemieux I. Abdominal obesity and metabolic syndrome. // Nature. – 2006. – V.444(7121). – P. 881-887. doi: 10.1038/nature05488</mixed-citation><mixed-citation xml:lang="en">Després JP, Lemieux I.  Abdominal obesity and metabolic syndrome. Nature. 2006;444(7121):881-887. doi: 10.1038/nature05488</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kunnas T., Lahtio R., Kortelainen M.L., Kalela A., Nikkari S.T. Gln27Glu variant of Beta2-adrenoceptor gene affects male type fat accumulation in women. // Lipids Health Dis. – 2009. – V.8. – P.43. doi: 10.1186/1476-511X-8-43</mixed-citation><mixed-citation xml:lang="en">Kunnas T, Lahtio R, Kortelainen ML, Kalela A, Nikkari ST. Gln27Glu variant of Beta2-adrenoceptor gene affects male type fat accumulation in women. Lipids Health Dis. 2009;8:43. doi: 10.1186/1476-511X-8-43</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ferguson J.F., Phillips C.M., Tierney A.C., Pérez-Martínez P., Defoort C., Helal O. et al. Gene–nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. // Am. J. Clin. Nutr. – 2010. – V.91(3). – P.794–801. doi: 10.3945/ajcn.2009.28255</mixed-citation><mixed-citation xml:lang="en">Ferguson JF,  Phillips CM,  Tierney AC,  Pérez-Martínez P, Defoort C, Helal O, et  al.  Gene–nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Am. J. Clin. Nutr. 2010 ;91(3) :794–801. doi: 10.3945/ajcn.2009.28255</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips C.M., Goumidi L., Bertrais S., Field M.R., Ordovas J.M., Cupples L.A., et al. Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults. // J. Nutr. – 2010. – V.140(2). – P.238–244. doi: 10.3945/jn.109.115329</mixed-citation><mixed-citation xml:lang="en">Phillips CM, Goumidi L, Bertrais S, Field MR, Ordovas JM, Cupples LA,  et  al.  Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults. J. Nutr. 2010;140(2):238–244. doi: 10.3945/jn.109.115329</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Kvaloy K., Holmen J., Hveem K., Holmen T.L. Genetic effects on longitudinal changes from healthy to adverse weight and metabolic status—the HUNT study. // PLoS One. -2015. – V.10(10). – P.e0139632. doi: 10.1371/journal.pone.0139632</mixed-citation><mixed-citation xml:lang="en">Kvaloy K, Holmen J, Hveem   K, Holmen TL.  Genetic effects on longitudinal changes from healthy to adverse weight and metabolic status—the HUNT study. PLoS One. 2015;10(10):e0139632. doi: 10.1371/journal.pone.0139632</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sutherland J., McKinley B., Eckel R. The metabolic syndrome and inflammation. // Metab. Syndr. Relat. Disord. – 2004. – V.2(2). – P.82–104. doi: 10.1089/met.2004.2.82</mixed-citation><mixed-citation xml:lang="en">Sutherland J, McKinley B, Eckel R. The metabolic syndrome and inflammation. Metab. Syndr. Relat. Disord. 2004;2(2):82– 104. doi: 10.1089/met.2004.2.82</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Karelis A.D., Faraj M., Bastard J.P., St-Pierre D.H., Brochu M., Prud’homme D. et al. The metabolically healthy but obese individual presents a favorable inflammation profile. // J Clin Endocrinol Metab. – 2005. – V.90(7). – P.4145–4150. doi: 10.1210/jc.2005-0482</mixed-citation><mixed-citation xml:lang="en">Karelis AD, Faraj M, Bastard JP, St-Pierre DH, Brochu M, Prud’homme D,  et al. The metabolically healthy but obese individual presents a favorable inflammation profile. J Clin Endocrinol Metab. 2005;90(7):4145–4150.  doi: 10.1210/jc.2005-0482</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Gomez-Ambrosi J., Catalan V., Rodriguez A., Andrada P., Ramírez B., Ibáñez P. et al. Increased cardiometabolic risk factors and inflammation in adipose tissue in obese subjects classified as metabolically healthy. // Diabetes Care. – 2014. – V.37(10). – P.2813–2821. doi: 10.2337/dc14-0937</mixed-citation><mixed-citation xml:lang="en">Gomez-Ambrosi J, Catalan V, Rodriguez A, Andrada P, Ramírez B, Ibáñez P, et al. Increased cardiometabolic risk factors and inflammation in adipose tissue in obese subjects classified as metabolically healthy. Diabetes Care. 2014;37(10):2813–2821. doi: 10.2337/dc14-0937</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ahl S., Guenther M., Zhao S., James R., Marks J., Szabo A. et al. Adiponectin Levels Differentiate Metabolically Healthy vs Unhealthy Among Obese and Nonobese White Individuals. // J Clin Endocrinol Metab. – 2015. – V.100(11). – P.4172– 4180. doi: 10.1210/jc.2015-2765</mixed-citation><mixed-citation xml:lang="en">Ahl S, Guenther  M, Zhao  S, James  R, Marks  J, Szabo A, et al. Adiponectin Levels Differentiate Metabolically Healthy vs Unhealthy Among Obese and Nonobese White Individuals. J Clin Endocrinol Metab. 2015;100(11):4172–4180. doi: 10.1210/jc.2015-2765</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Ortega F.B., Lee D.C., Katzmarzyk P.T., Ruiz J.R., Sui X., Church T.S. et al. The intriguing metabolically healthy but obese phenotype: Cardiovascular prognosis and role of fitness. // Eur. Heart J. – 2013.V.34(5). – P.389–397. doi: 10.1093/eurheartj/ehs174</mixed-citation><mixed-citation xml:lang="en">Ortega FB, Lee DC, Katzmarzyk PT, Ruiz JR, Sui X, Church TS, et al. The intriguing metabolically healthy but obese phenotype: Cardiovascular prognosis and role of fitness. Eur. Heart J. 2013;34(5):389–397. doi: 10.1093/eurheartj/ehs174</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Jennings C.L., Lambert E.V., Collins M., Joffe Y., Levitt N.S., Goedecke J.H. Determinants of insulin-resistant phenotypes in normal-weight and obese Black African women. // Obesity (Silver Spring). – 2008. – V.16(7). – P.16029. doi: 10.1038/oby.2008.233</mixed-citation><mixed-citation xml:lang="en">Jennings CL,  Lambert EV,  Collins M,  Joffe Y,  Levitt NS,  Goedecke JH. Determinants of insulin-resistant phenotypes in normal-weight and obese Black African women. Obesity (Silver Spring). 2008;16(7):P.1602-9. doi: 10.1038/oby.2008.233</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Camhi S.M., Whitney Evans E., Hayman L.L., Lichtenstein A.H., Must A. Healthy eating index and metabolically healthy obesity in U.S. adolescents and adults. // Prev. Med. – 2015. – V.77. – P.23–27. doi: 10.1016/j.ypmed.2015.04.023</mixed-citation><mixed-citation xml:lang="en">Camhi SM, Whitney Evans E, Hayman LL, Lichtenstein AH, Must A. Healthy eating index and metabolically healthy obesity in U.S. adolescents and adults. Prev. Med. 2015;77:23–27. doi: 10.1016/j.ypmed.2015.04.023</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Pujia A., Gazzaruso C., Ferro Y., Mazza E., Maurotti S., Russo C. et al. Individuals with Metabolically Нealthy Overweight/Obesity Have Higher Fat Utilization than Metabolically Unhealthy Individuals. // Nutrients. – 2016. – V.8(1). – P.2. doi:10.3390/nu8010002</mixed-citation><mixed-citation xml:lang="en">Pujia A, Gazzaruso C, Ferro Y, Mazza E, Maurotti S, Russo C, et al. Individuals with Metabolically Нealthy Overweight/ Obesity Have Higher Fat Utilization than Metabolically Unhealthy Individuals. Nutrients. 2016;8(1):2. doi:10.3390/nu8010002</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Park Y.M., Steck S.E., Fung T.T., Zhang J., Hazlett L.J., Han K. et al. Mediterranean diet and mortality risk in metabolically healthy obese and metabolically unhealthy obese phenotypes. // Int. J. Obes. – 2016. – V.40(10). – P.1541-1549. doi: 10.1038/ijo.2016.114</mixed-citation><mixed-citation xml:lang="en">Park YM, Steck SE, Fung TT, Zhang J, Hazlett LJ, Han K, et al. Mediterranean diet and mortality risk in metabolically healthy obese and metabolically unhealthy obese phenotypes. Int. J. Obes. 2016;40(10):1541-1549. doi:  10.1038/ ijo.2016.114</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips C.M., Perry I.J. Does inflammation determine metabolic health status in obese and nonobese adults? // J Clin Endocrinol Metab. – 2013. – V.98(10). – P.E1610–E1619. doi: 10.1210/jc.2013-2038</mixed-citation><mixed-citation xml:lang="en">Phillips CM, Perry IJ. Does inflammation determine metabolic health status in obese and nonobese adults? J Clin Endocrinol Metab. 2013;98(10):E1610–E1619. doi: 10.1210/ jc.2013-2038</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Flint H.J., Scott K.P., Louis P., Duncan S.H. The role of the gut microbiota in nutrition and health. // Nature Reviews. Gastroenterology and Hepatology. – 2012. – V.9(10). – P.577– 589. doi:10.1038/nrgastro.2012.156</mixed-citation><mixed-citation xml:lang="en">Flint  HJ,  Scott  KP,  Louis  P,  Duncan  SH.  The role of the gut microbiota in nutrition and health. Nature Reviews. Gastroenterology and Hepatology. 2012;9(10):577–589. doi:10.1038/nrgastro.2012.156</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Aung K., Lorenzo C., Hinojosa M.A., Haffner S.M. Risk of developing diabetes and cardiovascular disease in metabolically unhealthy normal-weight and metabolically healthy obese individuals. // J Clin Endocrinol Metab. – 2014. – V.99(2). – P.462–468. doi: 10.1210/jc.2013-2832</mixed-citation><mixed-citation xml:lang="en">Aung K, Lorenzo C, Hinojosa MA, Haffner SM. Risk of developing diabetes and cardiovascular disease in metabolically unhealthy normal-weight and metabolically healthy obese individuals. J Clin Endocrinol Metab. 2014;99(2):462–468. doi: 10.1210/jc.2013-2832</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Hinnouho G.M., Czernichow S., Dugravot A., Nabi H., Brunner E.J., Kivimaki M. et al. Metabolically healthy obesity and the risk of cardiovascular disease and type 2 diabetes: the Whitehall II cohort study. // Eur Heart J. – 2015. – V.36(9). – P.551–559. doi: 10.1093/eurheartj/ehu123</mixed-citation><mixed-citation xml:lang="en">Hinnouho GM, Czernichow S, Dugravot A, Nabi H, Brunner EJ, Kivimaki M, et al. Metabolically healthy obesity and the risk of cardiovascular disease and type 2 diabetes: the Whitehall II cohort study. Eur Heart J. 2015;36(9):551– 559. doi: 10.1093/eurheartj/ehu123</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Hamer M., Stamatakis E. Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality. // J. Clin. Endocrinol. Metab. – 2012. – 97(7). – P.2482–2488. doi: 10.1210/jc.2011-3475</mixed-citation><mixed-citation xml:lang="en">Hamer M, Stamatakis E.  Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality. J. Clin. Endocrinol. Metab. 2012;97(7):2482–2488. doi: 10.1210/jc.2011-3475</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Flint A.J., Hu F.B., Glynn R.J., Caspard H., Manson J.E., Willett W.C. et al. Excess weight and the risk of incident coronary heart disease among men and women. // Obesity (Silver Spring). – 2010. – V.18(2). – P. 377–383. doi: 10.1038/oby.2009.223 38.</mixed-citation><mixed-citation xml:lang="en">Flint AJ, Hu FB, Glynn RJ, Caspard H, Manson JE, Willett WC, et al. Excess weight and the risk of incident coronary heart disease among men and women. Obesity (Silver Spring). 2010;18(2):377–383. doi: 10.1038/oby.2009.223</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Kang Y.M., Jung C.H., Jang J.E., Hwang J.Y., Kim E.H., Park J.Y. et al. The association of incident hypertension with metabolic health and obesity status: definition of metabolic health does not matter. // Clin Endocrinol (Oxf). – 2016. – V.85(2). – P.207–215. doi: 10.1111/cen.13074</mixed-citation><mixed-citation xml:lang="en">Kang YM, Jung CH, Jang JE, Hwang JY, Kim EH, Park JY, et al. The association of incident hypertension with metabolic health and obesity status: definition of metabolic health does not matter. Clin Endocrinol (Oxf). 2016;85(2):207–215. doi: 10.1111/cen.13074</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Arnlov J., Sundstrom J., Ingelsson E., Lind L. Impact of BMI and the metabolic syndrome on the risk of diabetes in middle-aged men. // Diabetes Care. – 2011. V.34(1). – P.61–65. doi: 10.2337/dc10-0955</mixed-citation><mixed-citation xml:lang="en">Arnlov J,  Sundstrom J,  Ingelsson E, Lind L. Impact of BMI and the metabolic syndrome on the risk of diabetes in middle-aged men. Diabetes Care. 2011;34(1):61–65. doi: 10.2337/ dc10-0955</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Lassale C., Tzoulaki I., MoonsK.G.M., Sweeting M., Boer J., Johnson L. et al. Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis. // European Heart Journal. -2017. ehx448. doi: 10.1093/eurheartj/ehx448</mixed-citation><mixed-citation xml:lang="en">Lassale C, Tzoulaki I,  MoonsK.GM,  Sweeting  M, Boer J, Johnson L, et al.  Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis. European Heart Journal. 2017:ehx448. doi: 10.1093/eurheartj/ehx448</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng R., Zhou D., Zhu Y. The long-term prognosis of cardiovascular disease and all-cause mortality for metabolically healthy obesity: a systematic review and metaanalysis. // J Epidemiol Community Health. – 2016. – V.70(10). – P.1024-31. doi: 10.1136/jech-2015-206948</mixed-citation><mixed-citation xml:lang="en">Zheng R,  Zhou D,  Zhu Y. The long-term prognosis of cardiovascular disease and all-cause mortality for metabolically healthy obesity: a systematic review and meta-analysis. J Epidemiol Community Health. 2016;70(10):1024-31. doi: 10.1136/jech-2015-206948</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hashimoto Y., Tanaka M., Okada H., Senmaru T., Hamaguchi M., Asano M. et al. Metabolically healthy obesity and risk of incident CKD. // Clin J Am Soc Nephrol – 2015. – V.10(4). – P.578–583. doi: 10.2215/CJN.08980914</mixed-citation><mixed-citation xml:lang="en">Hashimoto Y, Tanaka M, Okada H, Senmaru T, Hamaguchi M, Asano M, et al. Metabolically healthy obesity and risk of incident CKD. Clin J Am Soc Nephrol. 2015 ;10(4) :578–583. doi: 10.2215/CJN.08980914</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Chang Y., Ryu S., Choi Y., Zhang Y., Cho J., Kwon M.J. et al. Metabolically healthy obesity and development of chronic kidney disease: a cohort study. // Ann Intern Med – 2016. – V.164(5). – P.305–312. doi: 10.7326/M15-1323</mixed-citation><mixed-citation xml:lang="en">Chang Y, Ryu S, Choi Y, Zhang Y, Cho J, Kwon MJ, et al. Metabolically healthy obesity and development of chronic kidney disease: a cohort study. Ann Intern Med. 2016;164(5):305– 312. doi: 10.7326/M15-1323</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Janiszewski P.M., Ross R. Effects of weight loss among metabolically healthy obese men and women. // Diabetes Care. – 2010. – V.33(9). – P.1957–1959. doi: 10.2337/dc10-0547</mixed-citation><mixed-citation xml:lang="en">Janiszewski PM, Ross R. Effects of weight loss among metabolically healthy obese men and women. Diabetes Care. 2010;33(9):1957–1959. doi: 10.2337/dc10-0547</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Kantartzis K., Machann J., Schick F., Rittig K., Machicao F., Fritsche A., et al. Effects of a lifestyle intervention in metabolically benign and malign obesity. // Diabetologia. – 2011. – V.54(5). – P.864–868. doi: 10.1007/s00125-010-2006-3</mixed-citation><mixed-citation xml:lang="en">Kantartzis K, Machann J, Schick F, Rittig K, Machicao F, Fritsche A, et al. Effects of a lifestyle intervention in metabolically benign and malign obesity. Diabetologia. 2011;54(5):864– 868. doi: 10.1007/s00125-010-2006-3</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Shin M.J., Hyun Y.J., Kim O.Y., Kim J.Y., Jang Y., Lee J.H. Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women. // Int J Obes (London). – 2006. – V.30(10). – P.1529–1534. DOI: 10.1038/ sj.ijo.0803304</mixed-citation><mixed-citation xml:lang="en">Shin MJ, Hyun YJ, Kim OY, Kim JY, Jang Y, Lee JH. Weight loss effect on inflammation and LDL oxidation in metaboli cally healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women. Int J Obes (London). 2006;30(10):1529–1534. DOI: 10.1038/sj.ijo.0803304</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Karelis A.D., Messier V., Brochu M., Rabasa-Lhoret R. Metabolically healthy but obese women: effect of an energy-restricted diet. // Diabetologia. – 2008. – V.51(9). – P.1752-4. doi: 10.1007/s00125-008-1038-4</mixed-citation><mixed-citation xml:lang="en">Karelis AD, Messier V, Brochu M, Rabasa-Lhoret R. Metabolically healthy but obese women: effect of an energy-restricted diet. Diabetologia. 2008;51(9):1752-4. doi: 10.1007/s00125008-1038-4</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Liu R.H., Wharton S., Sharma A.M., Ardern C.I., Kuk J.L. Influence of a clinical lifestyle-based weight loss program on the metabolic risk profile of metabolically normal and abnormal obese adults. // Obesity (Silver Spring) – 2013. – V.21(8). – P.1533–1539. doi: 10.1002/oby.20219</mixed-citation><mixed-citation xml:lang="en">Liu RH, Wharton S, Sharma AM, Ardern CI, Kuk JL. Influence of a clinical lifestyle-based weight loss program on the metabolic risk profile of metabolically normal and abnormal obese adults. Obesity (Silver Spring). 2013;21(8):1533–1539. doi: 10.1002/oby.20219</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Dalleck L.C., Van Guilder G.P., Richardson T.B., Bredle D.L., Janot J.M. A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype. // Diabetes Metab. Syndr. Obes. – 2014. – V.7. – P.369–380. doi: 10.2147/DMSO. S67441</mixed-citation><mixed-citation xml:lang="en">Dalleck LC,  Van Guilder GP,  Richardson TB,  Bredle DL, Janot JM. A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype. Diabetes Metab. Syndr. Obes. 2014;7:369–380. doi: 10.2147/DMSO.S67441</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Soriguer F., Gutiérrez-Repiso C., Rubio-Martín E., GarcíaFuentes E., Almaraz M.C., Colomo N., et al. Metabolically healthy but obese, a matter of time? Findings from the prospective Pizarra study. // J Clin Endocrinol Metab – 2013. – V.98(6). – P.2318–2325. doi: 10.1210/jc.2012-4253</mixed-citation><mixed-citation xml:lang="en">Soriguer F, Gutiérrez-Repiso C, Rubio-Martín E, GarcíaFuentes E, Almaraz MC, Colomo N, et al. Metabolically healthy but obese, a matter of time? Findings from the prospective Pizarra study. J Clin Endocrinol Metab. 2013;98(6):2318–2325. doi: 10.1210/jc.2012-4253</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Li S., Chen W., Srinivasan S.R., Xu J., Berenson G.S. Relation of childhood obesity/cardiometabolic phenotypes to adult cardiometabolic profile: the Bogalusa Heart Study. // Am. J. Epidemiol. – 2012. – V.176(7). – P.S142–S149. doi: 10.1093/aje/kws236</mixed-citation><mixed-citation xml:lang="en">Li S, Chen W, Srinivasan SR, Xu J, Berenson GS. Relation of childhood obesity/cardiometabolic phenotypes to adult cardiometabolic profile: the Bogalusa Heart Study. Am. J. Epidemiol. 2012;176(7):S142–S149. doi: 10.1093/aje/kws236</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Appleton S.L., Seaborn C.J., Visvanathan R., Hill C.L., Gill T.K., Taylor A.W. Diabetes and cardiovascular disease outcomes in the metabolically healthy obese phenotype: a cohort study. // Diabetes Care. – 2013. – V.36(8). – P.2388– 2394. doi: 10.2337/dc12-1971</mixed-citation><mixed-citation xml:lang="en">Appleton SL, Seaborn CJ, Visvanathan R, Hill CL, Gill TK, Taylor AW. Diabetes and cardiovascular disease outcomes in the metabolically healthy obese phenotype: a cohort study. Diabetes Care.  2013;36(8):2388–2394. doi: 10.2337/dc121971</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Eshtiaghi R., Keihani S., Hosseinpanah F., Barzin M., Azizi F. Natural course of metabolically healthy abdominal obese adults aft er 10 years of follow-up: the Tehran Lipid and Glucose Study. // Int. J. Obes. – 2015. – V.39(3). – P.514–519. doi: 10.1038/ijo.2014.176</mixed-citation><mixed-citation xml:lang="en">Eshtiaghi R, Keihani S, Hosseinpanah F, Barzin M, Azizi F. Natural course of metabolically healthy abdominal obese adults aft er 10 years of follow-up: the Tehran Lipid and Glucose Study. Int. J. Obes. 2015;39(3):514–519. doi: 10.1038/ ijo.2014.176</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Hamer M., Bell J.A., Sabia S., Batty G.D., Kivimäki M. Stability of metabolically healthy obesity over 8 years: the English Longitudinal Study of Ageing. // Eur. J. Endocrinol. – 2015. – V.173(5). – P.703–708. doi: 10.1530/EJE-15-0449</mixed-citation><mixed-citation xml:lang="en">Hamer M, Bell JA, Sabia S, Batty GD, Kivimäki M. Stability of metabolically healthy obesity over 8 years: the English Longitudinal Study of Ageing. Eur. J. Endocrinol. 2015;173(5):703–708. doi: 10.1530/EJE-15-0449</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Schröder H., Ramos R., Baena-Díez J.M., Mendez M.A., Canal D.J., Fíto M. et al. Determinants of the transition from a cardiometabolic normal to abnormal overweight/obese phenotype in a Spanish population. // Eur J Nutr. – 2014. – V.53(6). – P.1345–1353. doi: 10.1007/s00394-013-0635-2</mixed-citation><mixed-citation xml:lang="en">Schröder H, Ramos R, Baena-Díez JM, Mendez MA, Canal DJ, Fíto M, et al. Determinants of the transition from a cardiometabolic normal to abnormal overweight/ obese phenotype in a Spanish population. Eur J Nutr. 2014;53(6):1345–1353. doi: 10.1007/s00394-013-0635-2</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Bluher M. The distinction of metabolically ‘healthy’ from ‘unhealthy’ obese individuals. // Curr Opin Lipidol. – 2010. – V.21(1). – P.38–43. doi: 10.1097/MOL.0b013e3283346ccc</mixed-citation><mixed-citation xml:lang="en">Bluher M. The distinction of metabolically ‘healthy’ from ‘unhealthy’ obese individuals. Curr Opin Lipidol. 2010;21(1):38– 43. doi: 10.1097/MOL.0b013e3283346ccc</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Волкова Н.И., Поркшеян М.И., Гюльмагомедова А.Н. Лечение ожирения: история взлетов и падений. // Медицинский вестник Юга России. – 2015. – №1. – С.21-26. doi: 10.21886/2219-8075-2015-1-21-26</mixed-citation><mixed-citation xml:lang="en">Volkova NI, Porksheyan MI, Gyulmagomedova AN. Treatment for obesity: the history of flights&amp;falls. Medical Herald of the South of Russia. 2015;(1):21-26. (In Russ.) DOI:10.21886/2219-8075-2015-1-21-26</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report. Bethesda (MD): National Heart, Lung, and Blood Institute; 1998.</mixed-citation><mixed-citation xml:lang="en">Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report. Bethesda (MD): National Heart, Lung, and Blood Institute; 1998.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
