mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2017-1-21-27mvjr-487Research ArticleОБЗОРЫREVIEWМЕХАНИЗМЫ ФОРМИРОВАНИЯ ФИБРОЗА ПОЧЕК С УЧЕТОМ МИКРОСОСУДИСТОГО ПОРАЖЕНИЯMECHANISMS OF FORMATION OF KIDNEY FIBROSIS BASED ON MICROVASCULAR LESIONSЛевицкаяЕ. С.LevitskayaE. S.

кандидат медицинских наук, ассистент кафедры внутренних болезней №2, направление - кардиология, нефрология, морфология

Россия, 344022, Ростов-на-Дону, пер. Нахичеванский, 29

29 Nakhichevanskiy st., Rostov-on-Don, 344022 Russia

es.med@mail.ruФГБОУ ВО РостГМУ Минздрава РоссииРоссияRostov State Medical UniversityRussian Federation201730032017012127Copyright © Левицкая Е.С., 20172017Левицкая Е.С.Levitskaya E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/487

Обзор посвящен описанию механизмов, участвующих в формировании фиброза почек. Представлены молекулярные факторы активации патологического процесса, сигнальных путей, компетентные клетки с синтезированием провосполительных медиаторов, роль эпителиально-мезенхимального перехода в развитии и прогрессировании фиброза почек. Продемонстрированы данные, свидетельствующие о значимости ремоделирования почечных артерий малого диаметра в развитии и прогрессировании фиброза почечной ткани. В качестве источников информации для полного раскрытия темы обзорной статьи с представлением современных взглядов на изучение данной проблемы, использованы базы цитирований PubMed, РИНЦ, Scopus, Web of Science, Google Scholar, Index Copernicus, Ulrich’s Periodicals Directory.

The review deals with the description of the mechanisms involved in the formation of kidney fibrosis. Presented molecular factors activation of the pathological process, signaling pathways, competent cells with synthetic provospolitelnyh mediators, the role of epithelial-mesenchymal transition in the development and progression of renal fibrosis. Demonstrated evidence of the importance of the remodeling of the renal arteries of small diameter in the development and progression of renal fibrosis tissue. Sources of information on topics Review article full disclosure, a presentation of the current views on the study of this problem, use the database PubMed citations, RISC, Scopus, Web- Mathematical Sciences, Google Scholar, Copernicus index, Ulrich Periodicals Directory.

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The authors declare that there are no conflicts of interest present.