mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2017-1-12-20mvjr-353Research ArticleОБЗОРЫREVIEWРЕГУЛЯЦИЯ ВИТАМИНОМ D МЕТАБОЛИЗМА КОСТНОЙ ТКАНИVITAMIN D REGULATION OF BONE METABOLISMМайлянЭ. А.MaylyanE. A.

Кафедра клинической иммунологии, аллергологии и эндокринологии

Доцент

ДНР, 283003, Донецк, пр. Ильича, 16

16 Illicha Ave., Donetsk 283003, DPR

mea095@yandex.ruРезниченкоН. А.RheznichenkoN. A.

ДНР, 283003, Донецк, пр. Ильича, 16

16 Illicha Ave., Donetsk 283003, DPR

professorreznichenko@mail.ruМайлянД. Э.MaylyanD. E.

ДНР, 283003, Донецк, пр. Ильича, 16

16 Illicha Ave., Donetsk 283003, DPR

MEA095@ya.ruДонецкий национальный медицинский университет им. М.ГорькогоУкраинаDonetsk National Medical University named after M. GorkyUkraine201730032017011220Copyright © Майлян Э.А., Резниченко Н.А., Майлян Д.Э., 20172017Майлян Э.А., Резниченко Н.А., Майлян Д.Э.Maylyan E.A., Rheznichenko N.A., Maylyan D.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/353

Основная функция витамина D (1,25(OH)2D) заключается в поддержании нормальных концентраций кальция и фосфатов в плазме крови, которые необходимы для адекватной минерализации костной ткани и скелетообразования. В настоящее время установлено, что витамин D может и непосредственно участвовать в метаболизме костной ткани, прямо воздействуя через рецепторы витамина D (VDR) на ее клеточные элементы - хондроциты, остеобласты, остеоциты и остеокласты. Причем, неоспоримым является тот факт, что механизмы как стимулирования кишечной абсорбции кальция и фосфора, так и непосредственного воздействия витамина D на клетки кости являются значимыми и взаимодополняющими друг друга в процессе полноценной регуляции метаболизма костной ткани.

The main vitamin D (1,25(OH)2D) function lies in maintaining of calcium and phosphates normal concentrations in a blood plasma that is necessary for adequate bone tissue mineralization and skillet formation. Now there’s no doubt that vitamin D immediately participates in the bone tissue metabolism, directly influencing through VDR receptors located on cells: chondrocytes, osteoblasts, osteocytes and osteoclasts. At that, mechanisms of calcium and phosphorus intestinal absorption stimulation and immediate vitamin D influence on bone cells are significant and complementary in the full-fledged bone tissue metabolism regulation process.

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The authors declare that there are no conflicts of interest present.