mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2016-1-28-32mvjr-303Research ArticleОБЗОРЫREVIEWДЕПРЕССИВНЫЕ РАССТРОЙСТВА У БОЛЬНЫХ СЕРДЕЧНО-СОСУДИСТЫМИ ЗАБОЛЕВАНИЯМИ: ВЛИЯНИЕ НА ПРОГНОЗDEPRESSIVE DISORDERS IN PATIENTS WITH CARDIOVASCULAR DISEASE: DETERMINING THE PROGNOSISИванченкоД. Н.IvanchenkoD. N.d_ivanchenko@mail.ruДорофееваН. П.DorofeevaN. P.ШлыкС. В.ShlykS. V.Ростовский государственный медицинский университет, Кафедра терапии ФПК и ППС, Россия, 344022, г. Ростов-на-Дону, пер. Нахичеванский, 29РоссияRostov State Medical University, Department of Faculty training and retraining, 29 Nakhichevansky st., Rostov-on-Don, Russia, 344022Russian Federation201630032016012832Copyright © Иванченко Д.Н., Дорофеева Н.П., Шлык С.В., 20162016Иванченко Д.Н., Дорофеева Н.П., Шлык С.В.Ivanchenko D.N., Dorofeeva N.P., Shlyk S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/303

Несмотря на достигнутые успехи в диагностике и лечении сердечно-сосудистых заболеваний, кардиальная смертность продолжает занимать лидирующие позициив структуре общей смертности. Наряду с этим, было отмечено, что среди лиц с кардиальной патологией велика распространенность расстройств депрессивного спектра. Последние способствуют ухудшению кардиального прогноза, как у больных сердечно-сосудистыми заболеваниями, так и у лиц без кардиальной патологии.В статье изложены основные патофизиологические механизмы взаимодействия симптомов депрессии и сердечно-сосудистого заболевания. Кроме того, уделено внимание диагностике симптомов депрессии, как фактора, определяющего кардиальный прогноз.

Despite the advances in the diagnosis and treatment of cardiovascular diseases, the cardiac mortality takes a leading position among the causes of general mortality. It was also noted that depressive disorders are widespread among the cardiovascular patients. They induce the impairment of cardiac prognosis both in patients with cardiovascular disease and in patients without cardiac disease. The article outlines the basic pathophysiological mechanisms of interaction between depressive symptoms and cardiovascular disease. In addition, the article focuses on the diagnosis of depressive symptoms as a factor determining cardiac prognosis.

сердечно-сосудистые заболеваниядепрессивные расстройствакардиальный прогнозcardiovascular diseasedepressive disorderscardiac prognosis.ReferencesAlonso J, Angermeyer MC, Bernert S et al: Prevalence of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. ActaPsychiatrScandSuppl 2004:21–27.Alonso J, Angermeyer MC, Bernert S et al: Prevalence of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. ActaPsychiatrScandSuppl 2004:21–27.Mathers CD, Loncar D: Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006, 3:e442.Mathers CD, Loncar D: Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006, 3:e442.Penninx B, Yuri Milaneschi Y, Lamers F and Vogelzangs N Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile BMC Medicine 2013, 11:129. http://www.biomedcentral.com/1741-7015/11/129Penninx B, Yuri Milaneschi Y, Lamers F and Vogelzangs N Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile BMC Medicine 2013, 11:129. http://www.biomedcentral.com/1741-7015/11/129R. C. Kessler, P. Berglund, O. Demler et al., “The epidemiology of major depressive disorder: results from the national comorbidity survey replication (NCS-R),” The Journal of the American Medical Association, vol. 289, no. 23, pp. 3095–3105, 2003.R. C. Kessler, P. Berglund, O. Demler et al., “The epidemiology of major depressive disorder: results from the national comorbidity survey replication (NCS-R),” The Journal of the American Medical Association, vol. 289, no. 23, pp. 3095–3105, 2003.T. Rutledge, V. A. Reis, S. E. Linke, B. H. Greenberg, and P. J. Mills, “Depression in heart failure. A meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes,” Journal of the American College of Cardiology, vol. 48, no. 8, pp. 1527–1537, 2006.T. Rutledge, V. A. Reis, S. E. Linke, B. H. Greenberg, and P. J. Mills, “Depression in heart failure. A meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes,” Journal of the American College of Cardiology, vol. 48, no. 8, pp. 1527–1537, 2006.P. J. McCabe, “Psychological distress in patients diagnosed with atrial fibrillation: the state of the science,” Journal of Cardiovascular Nursing, vol. 25, no. 1, pp. 40–51, 2010.P. J. McCabe, “Psychological distress in patients diagnosed with atrial fibrillation: the state of the science,” Journal of Cardiovascular Nursing, vol. 25, no. 1, pp. 40–51, 2010.P. J. Tully and R. A. Baker, “Depression, anxiety, and cardiac morbidity outcomes after coronary artery bypass surgery: a contemporary and practical review,” Journal of Geriatric Cardiology, vol. 9, no. 2, pp. 197–208, 2012.P. J. Tully and R. A. Baker, “Depression, anxiety, and cardiac morbidity outcomes after coronary artery bypass surgery: a contemporary and practical review,” Journal of Geriatric Cardiology, vol. 9, no. 2, pp. 197–208, 2012.N. E.Morone, D. K. Weiner, B.H. Belnap et al., “The impact of pain and depression on recovery after coronary artery bypassgrafting,” Psychosomatic Medicine, vol. 72, no. 7, pp. 620–625, 2010.N. E.Morone, D. K. Weiner, B.H. Belnap et al., “The impact of pain and depression on recovery after coronary artery bypassgrafting,” Psychosomatic Medicine, vol. 72, no. 7, pp. 620–625, 2010.J. C.Huffman, C. A.Mastromauro, G. L. Sowden, C.Wittmann, R. Rodman, and J. L. Januzzi, “A collaborative care depressionmanagement program for cardiac inpatients: depression characteristics and in-hospital outcomes,” Psychosomatics, vol. 52,no. 1, pp. 26–33, 2011.J. C.Huffman, C. A.Mastromauro, G. L. Sowden, C.Wittmann, R. Rodman, and J. L. Januzzi, “A collaborative care depressionmanagement program for cardiac inpatients: depression characteristics and in-hospital outcomes,” Psychosomatics, vol. 52,no. 1, pp. 26–33, 2011.Wulsin LR, Singal BM. Do depressive symptoms increase the risk for the onset of coronary disease? A systematic quantitative review. Psychosom Med 2003;65:201–210.Wulsin LR, Singal BM. Do depressive symptoms increase the risk for the onset of coronary disease? A systematic quantitative review. Psychosom Med 2003;65:201–210.R. L. Reese, K. E. Freedland, B. C. Steinmeyer,M.W. Rich, J.W. Rackley, and R. M. Carney, “Depression and rehospitalization following acute myocardial infarction,” Circulation: Cardiovascular Quality and Outcomes, vol. 4, no. 6, pp. 626–633, 2011.R. L. Reese, K. E. Freedland, B. C. Steinmeyer,M.W. Rich, J.W. Rackley, and R. M. Carney, “Depression and rehospitalization following acute myocardial infarction,” Circulation: Cardiovascular Quality and Outcomes, vol. 4, no. 6, pp. 626–633, 2011.Marcus MD, Wing RR, Guare J, Blair EH, Jawad A. Lifetime prevalence of major depression and its effect on treatment outcome in obese type II diabetic patients. Diabetes Care 1992;15:253–255.Marcus MD, Wing RR, Guare J, Blair EH, Jawad A. Lifetime prevalence of major depression and its effect on treatment outcome in obese type II diabetic patients. Diabetes Care 1992;15:253–255.DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. ArchInternMed 2000;160:2101–2107.DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. ArchInternMed 2000;160:2101–2107.Дмитриева Т.Б. Системы нейромедиторов и нейроспецифичных белков в оценке функций мозга человека и животных: теоретические и клинические аспекты: В кн. «Мозг. Теоретические и клинические аспекты». М.: Медицина, 2003. – 536 с.Дмитриева Т.Б. Системы нейромедиторов и нейроспецифичных белков в оценке функций мозга человека и животных: теоретические и клинические аспекты: В кн. «Мозг. Теоретические и клинические аспекты». М.: Медицина, 2003. – 536 с.R. S. Duman, “Pathophysiology of depression: the concept of synaptic plasticity,” European Psychiatry, vol. 17, no. 3, pp. 306–310, 2002.R. S. Duman, “Pathophysiology of depression: the concept of synaptic plasticity,” European Psychiatry, vol. 17, no. 3, pp. 306–310, 2002.L. M. Holsen, K. Lancaster, A. Klibanski et al., “HPA-Axis hormone modulation of stress response circuitry activity in women with remittedmajor depression,” Neuroscience, vol. 250, pp. 733–742, 2013.L. M. Holsen, K. Lancaster, A. Klibanski et al., “HPA-Axis hormone modulation of stress response circuitry activity in women with remittedmajor depression,” Neuroscience, vol. 250, pp. 733–742, 2013.Gingrich J.A., Hen R. Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice // Psychopharmacology. – 2001. – Vol. 155. – Р. 1–10.Gingrich J.A., Hen R. Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice // Psychopharmacology. – 2001. – Vol. 155. – Р. 1–10.Marazziti D, Baroni S, Picchett M et al. Psychiatric disorders and mitochondrial dysfunctions European Review for Medical and Pharmacological Sciences 2012; 16: 270-275.Marazziti D, Baroni S, Picchett M et al. Psychiatric disorders and mitochondrial dysfunctions European Review for Medical and Pharmacological Sciences 2012; 16: 270-275.Porges SW: The polyvagal theory: phylogenetic substrates of a social nervous system. Int J Psychophysiol 2001, 42:123–146.Porges SW: The polyvagal theory: phylogenetic substrates of a social nervous system. Int J Psychophysiol 2001, 42:123–146.A.H. Kemp, D. S. Quintana, M. A. Gray, K. L. Felmingham, K. Brown, and J.M.Gatt, “Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis,” Biological Psychiatry, vol. 67, no. 11, pp. 1067–1074, 2010.A.H. Kemp, D. S. Quintana, M. A. Gray, K. L. Felmingham, K. Brown, and J.M.Gatt, “Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis,” Biological Psychiatry, vol. 67, no. 11, pp. 1067–1074, 2010.Belmaker RH, Agam G: Major depressive disorder. N Engl J Med 2008, 358:55–68.Belmaker RH, Agam G: Major depressive disorder. N Engl J Med 2008, 358:55–68.deKloet ER, Joels M, Holsboer F: Stress and the brain: from adaptation to disease. Nat Rev Neurosci 2005, 6:463–475.deKloet ER, Joels M, Holsboer F: Stress and the brain: from adaptation to disease. Nat Rev Neurosci 2005, 6:463–475.Silverman MN, Sternberg EM: Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Ann N Y AcadSci 2012, 1261:55–63.Silverman MN, Sternberg EM: Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Ann N Y AcadSci 2012, 1261:55–63.A. Gehi, D. Musselman, C. Otte, E. B. Royster, S. Ali, and M. A. Whooley, “Depression and platelet activation in outpatientswith stable coronary heart disease: findings from the heart and soul study,” Psychiatry Research, vol. 175, no. 3, pp. 200–204,2010.A. Gehi, D. Musselman, C. Otte, E. B. Royster, S. Ali, and M. A. Whooley, “Depression and platelet activation in outpatientswith stable coronary heart disease: findings from the heart and soul study,” Psychiatry Research, vol. 175, no. 3, pp. 200–204,2010.Сушкина И.Ф., Дорофеева Н.П., Шлык С.В. Оценка качества жизни у больных острым коронарным синдромом в сочетании с сахарным диабетом 2 типа / Медицинский вестник Юга России. – 2014. - №1. - с. 90-93.Сушкина И.Ф., Дорофеева Н.П., Шлык С.В. Оценка качества жизни у больных острым коронарным синдромом в сочетании с сахарным диабетом 2 типа / Медицинский вестник Юга России. – 2014. - №1. - с. 90-93.Pan A, Sun Q, Czernichow S, et al. Bidirectional association between depression and obesity in middle-aged and older women. Int J Obes (Lond) 2012;36: 595–602.Pan A, Sun Q, Czernichow S, et al. Bidirectional association between depression and obesity in middle-aged and older women. Int J Obes (Lond) 2012;36: 595–602.Black PH. The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain BehavImmun 2003; 17:350–364Black PH. The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain BehavImmun 2003; 17:350–364Kan C, Silva N, Golden SH et al. A Systematic Review and Metaanalysis of the Association BetweenDepressionand Insulin Resistance Diabetes Care 36:480–489, 2013.Kan C, Silva N, Golden SH et al. A Systematic Review and Metaanalysis of the Association BetweenDepressionand Insulin Resistance Diabetes Care 36:480–489, 2013.Pan A, Keum N, Okereke OI, Sun Q, Kivimaki M, Rubin RR, Hu FB: Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies. Diabetes Care 2012, 35:1171–1180.Pan A, Keum N, Okereke OI, Sun Q, Kivimaki M, Rubin RR, Hu FB: Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies. Diabetes Care 2012, 35:1171–1180.Krishnan V, Nestler EJ: Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry 2010, 167:1305– 1320.Krishnan V, Nestler EJ: Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry 2010, 167:1305– 1320.Maes M, Bosmans E, Meltzer HY, Scharpe S, Suy E: Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression? Am J Psychiatry 1993, 150:1189–1193.Maes M, Bosmans E, Meltzer HY, Scharpe S, Suy E: Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression? Am J Psychiatry 1993, 150:1189–1193.Maes M: A review on the acute phase response in major depression. Rev Neurosci 1993, 4:407–416.Maes M: A review on the acute phase response in major depression. Rev Neurosci 1993, 4:407–416.G.Kania, P. Blyszczuk, andU. Eriksson, “Mechanisms of cardiac fibrosis in inflammatory heart disease,” Trends in Cardiovascular Medicine, vol. 19, no. 8, pp. 247–252, 2009.G.Kania, P. Blyszczuk, andU. Eriksson, “Mechanisms of cardiac fibrosis in inflammatory heart disease,” Trends in Cardiovascular Medicine, vol. 19, no. 8, pp. 247–252, 2009.W. J. Kop, P. K. Stein, R. P. Tracy, J. I. Barzilay, R. Schulz, and J. S. Gottdiener, “Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression,” Psychosomatic Medicine,vol. 72, no. 7, pp. 626–635, 2010.W. J. Kop, P. K. Stein, R. P. Tracy, J. I. Barzilay, R. Schulz, and J. S. Gottdiener, “Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression,” Psychosomatic Medicine,vol. 72, no. 7, pp. 626–635, 2010.J. A. Jimenez and P. J. Mills, “Neuroimmune mechanisms of depression in heart failure,” Methods in Molecular Biology, vol. 934, pp. 165–182, 2012.J. A. Jimenez and P. J. Mills, “Neuroimmune mechanisms of depression in heart failure,” Methods in Molecular Biology, vol. 934, pp. 165–182, 2012.Panagiotakos DB, Pitsavos C, Chrysohoou C, et al. Inflammation, coagulation, and depressive symptomatology in cardiovascular disease-free people; the ATTICA study. Eur Heart J. 2004; 25: 492-499.Panagiotakos DB, Pitsavos C, Chrysohoou C, et al. Inflammation, coagulation, and depressive symptomatology in cardiovascular disease-free people; the ATTICA study. Eur Heart J. 2004; 25: 492-499.Sublette ME, Postolache TT: Neuroinflammation and depression: the role of indoleamine 2,3-dioxygenase (IDO) as a molecular pathway. Psychosom Med 2012, 74:668–672.Sublette ME, Postolache TT: Neuroinflammation and depression: the role of indoleamine 2,3-dioxygenase (IDO) as a molecular pathway. Psychosom Med 2012, 74:668–672.S. Verma, C. H. Wang, S. H. Li et al., “A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide productionand inhibits angiogenesis,” Circulation, vol. 106, no. 8, pp. 913–919, 2002.S. Verma, C. H. Wang, S. H. Li et al., “A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide productionand inhibits angiogenesis,” Circulation, vol. 106, no. 8, pp. 913–919, 2002.Zigmound A.S., Snaith R.P. The hospital anxiety and depression scale // Acta. Psychiatr. Scand. – 1983. – Vol.67. – P.361-370.Zigmound A.S., Snaith R.P. The hospital anxiety and depression scale // Acta. Psychiatr. Scand. – 1983. – Vol.67. – P.361-370.Андрюшенко А.В., Дробижев М.Ю., Добровольский А.В. Сравнительная оценка шкал CES-D, BDI и HADS(d) в диагностике депрессий в общемедицинской практике // Журн. неврол. и психиатрии им. С.С. Корсакова. - 2003. - № 103 (5). – С. 11-18.Андрюшенко А.В., Дробижев М.Ю., Добровольский А.В. Сравнительная оценка шкал CES-D, BDI и HADS(d) в диагностике депрессий в общемедицинской практике // Журн. неврол. и психиатрии им. С.С. Корсакова. - 2003. - № 103 (5). – С. 11-18.

The authors declare that there are no conflicts of interest present.