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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2219-8075-2026-17-2-104-108</article-id><article-id custom-type="elpub" pub-id-type="custom">mvjr-2167</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭПИДЕМИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EPIDEMIOLOGY</subject></subj-group></article-categories><title-group><article-title>Анализ случаев внутрибольничного инфицирования SARS-CoV-2:  факторы и группы риска, диагностика и профилактика</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of cases of nosocomial SARS-CoV-2 infection:  risk factors and groups, diagnosis and prevention</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-9939-2266</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пряников</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pryanikov</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пряников Григорий Алексеевич, аспирант кафедры эпидемиологии и доказательной медицины, Институт общественного здоровья им. Ф.Ф. Эрисмана</p><p>Москва</p></bio><bio xml:lang="en"><p>Grigory A. Pryanikov, postgraduate student at the Department of Epidemiology and Evidence–based Medicine, F.F. Institute of Public Health. ErismanI.M.</p><p>Moscow</p></bio><email xlink:type="simple">pryanikov@spbu.su</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-8510-6727</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванов Сергей Сергеевич, аспирант кафедры эпидемиологии и доказательной медицины, Институт общественного здоровья им. Ф.Ф. Эрисмана</p><p>Москва</p></bio><bio xml:lang="en"><p>Sergey S. Ivanov, postgraduate student at the Department of Epidemiology and Evidence-based Medicine, F.F. Institute of Public Health. Erisman M.</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>22</day><month>06</month><year>2026</year></pub-date><volume>17</volume><issue>2</issue><fpage>104</fpage><lpage>108</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пряников Г.А., Иванов С.С., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Пряников Г.А., Иванов С.С.</copyright-holder><copyright-holder xml:lang="en">Pryanikov G.A., Ivanov S.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/2167">https://www.medicalherald.ru/jour/article/view/2167</self-uri><abstract><p>Пандемия новой коронавирусной инфекции COVID-19 привела к существенным изменениям системы здравоохранения во всем мире с начала 2020 г. В начале пандемии лечебно-профилактические учреждения принимали необходимые меры как для ранней диагностики и своевременного лечения пациентов, так и для недопущения распространения инфекции. Были усилены меры инфекционного контроля, расширено использование средств индивидуальной защиты (повсеместное ношение масок для персонала и пациентов, тестирование бессимптомных пациентов, использование респираторов №95 и средств защиты глаз) для предотвращения передачи. На сегодняшний день в научной литературе отсутствует систематизированный анализ сведений о внутрибольничном инфицировании SARS-CoV-2. В ряде исследований приведены данные о том, что порядка 20% случаев заражения SARS-CoV-2 оказалось нозокомиальными. С появлением более контагиозных штаммов коронавируса в ряде одноцентровых исследованиях были описаны крупномасштабные вспышки, в том числе и среди вакцинированных пациентов. С декабря 2021 г., когда вариант SARSCoV-2 «Омикрон» стал доминирующим штаммом, риск инфицирования населения, особенно среди уязвимых групп, значительно вырос, рядом отечественных и зарубежных авторов отмечались многочисленные вспышки заболеваемости в пансионах и домах престарелых. Своевременная диагностика и оценка характера внутрибольничных инфекций в разных лечебно-профилактических учреждениях осложняется потенциальной изменчивостью методов больничного тестирования и симптоматического статуса пациентов с большим количеством случаев бессимптомного носительства. Цель — провести систематический обзор литературных источников по международным научным базам за последние 5 лет («PubMed», «Google Scholar», «Scopus») по ключевым словам: «внутрибольничные инфекции», «профилактика внутрибольничной передачи коронавирусной инфекции», «группы риска новой коронавирусной инфекции», «nosocomial infections», «prevention of nosocomial transmission of coronavirus infection», «risk groups for new coronavirus infection». Отобраны 29 источников, соответствующих критериям поиска для последующей систематизации. Источники содержат актуальную информацию о методах профилактики внутрибольничной передачи SARS-CoV-2, а также статистические сведения о данных по внутрибольничной заболеваемости. </p></abstract><trans-abstract xml:lang="en"><p>The pandemic of the new coronavirus infection COVID-19 has led to significant changes in the healthcare system</p><p>worldwide since the beginning of 2020. At the beginning of the pandemic, medical and preventive institutions took the necessary measures both for early diagnosis and timely treatment of patients, and to prevent the spread of infection. Infection control measures have been strengthened, and the use of personal protective equipment has been expanded (widespread wearing of masks for staff and patients, testing of asymptomatic patients, and the use of N95 respirators and eye protection) to prevent transmission. To date, there is no systematic analysis of information on hospital-acquired SARS-CoV-2 infection in the scientific literature. A number of studies have shown that about 20% of cases of SARS-CoV-2 infection turned out to be nosocomial. With the emergence of more contagious strains of coronavirus, large-scale outbreaks have been described in a number of single-center studies, including among vaccinated individuals. Since December 2021, when the SARS-CoV-2 variant “Omicron” became the dominant strain, the risk of infection of the population, especially among vulnerable groups, has increased significantly, and a number of domestic and foreign authors have noted numerous outbreaks of the disease in boarding schools and nursing home. Timely diagnosis and assessment of the nature of nosocomial infections in different medical institutions is complicated by the potential variability of hospital testing methods and the symptomatic status of patients with a large number of cases of asymptomatic carriage. The aim is to conduct a systematic review of literature sources on international scientific databases over the past 5 years (PubMed, Google Scholar, Scopus) by keywords: “nosocomial infections”, “prevention of nosocomial transmission of coronavirus infection”, “risk groups for new coronavirus infection”, “nosocomial infections”, “prevention of nosocomial transmission of coronavirus infection”, “risk groups for new coronavirus infection”. 29 sources were selected that meet the search criteria for subsequent systematization. The sources contain up-to-date information on methods of preventing nosocomial transmission of SARS-CoV-2, as well as statistical information on nosocomial morbidity.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>внутрибольничные инфекции</kwd><kwd>профилактика</kwd><kwd>коронавирусная инфекция</kwd><kwd>SARS-CoV-2</kwd><kwd>группы риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>review</kwd><kwd>nosocomial infections</kwd><kwd>prevention</kwd><kwd>coronavirus infection</kwd><kwd>SARS-CoV-2</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Акимкин В.Г., Давидова Н.Г., Углева С.В., Понежева Ж.Б., Шабалина С.В. Эпидемические очаги COVID-19 в зарубежных закрытых учреждениях долговременного ухода. Эпидемиология и Вакцинопрофилактика. 2022;21(5):138-146. https://doi.org/10.31631/20733046-2022-21-5-138-146</mixed-citation><mixed-citation xml:lang="en">Akimkin V.G., Davydova N.G., Ugleva S.V., Ponezheva Zh.B., Shabalina S.V. Epidemic Outbreak of COVID-19 in Foreign Closed Long-Term Care Facilities. Epidemiology and Vaccinal Prevention. 2022;21(5):138-146. (In Russ.) https://doi.org/10.31631/20733046-2022-21-5-138-146</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Брико Н.И., Коршунов В.А., Краснова С.В., Проценко Д.Н., Глазовская Л.С., и др. Клинико-эпидемиологические особенности пациентов, госпитализированных с COVID-19 в различные периоды пандемии в Москве. Журнал микробиологии, эпидемиологии и иммунобиологии. 2022;99(3):287-299. https://doi.org/10.36233/0372-9311-272</mixed-citation><mixed-citation xml:lang="en">Briko N.I., Korshunov V.A., Krasnova S.V., Protsenko D.N., Glazovskaya L.S., et al. Clinical and epidemiological characteristics of hospitalized patients with COVID-19 during different pandemic periods in Moscow. Journal of microbiology, epidemiology and immunobiology. 2022;99(3):287-299. (In Russ.) https://doi.org/10.36233/0372-9311-272</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Пряников Г.А. Анализ факторов риска у медицинского персонала в период пандемии COVID-19. Анализ риска здоровью – 2024. Материалы XIV Всероссийской научнопрактической конференции с международным участием. Пермь. 2024;2:291-297.</mixed-citation><mixed-citation xml:lang="en">Pryanikov GA. Analysis of risk factors among medical personnel during the COVID-19 pandemic. Health Risk Analysis-2024: Collection of articles of the XIV All-Russian Scientific and Practical Conference with International Participation. Perm. 2024;2:291-297. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou F, Yu T, Du R, Fan G, Liu Y, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):10541062. Erratum in: Lancet. 2020;395(10229):1038. Erratum in: Lancet. 2020;395(10229):1038. https://doi.org/10.1016/S0140-6736(20)30566-3</mixed-citation><mixed-citation xml:lang="en">Zhou F, Yu T, Du R, Fan G, Liu Y, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):10541062. Erratum in: Lancet. 2020;395(10229):1038. Erratum in: Lancet. 2020;395(10229):1038. https://doi.org/10.1016/S0140-6736(20)30566-3</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Möhlenkamp S, Thiele H. Ventilation of COVID-19 patients in intensive care units. Herz. 2020;45(4):329-331. https://doi.org/10.1007/s00059-020-04923-1</mixed-citation><mixed-citation xml:lang="en">Möhlenkamp S, Thiele H. Ventilation of COVID-19 patients in intensive care units. Herz. 2020;45(4):329-331. https://doi.org/10.1007/s00059-020-04923-1</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Alijotas-Reig J, Esteve-Valverde E, Belizna C, SelvaO’Callaghan A, Pardos-Gea J, et al. Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: A comprehensive review. Autoimmun Rev. 2020;19(7):102569. https://doi.org/10.1016/j.autrev.2020.102569</mixed-citation><mixed-citation xml:lang="en">Alijotas-Reig J, Esteve-Valverde E, Belizna C, SelvaO’Callaghan A, Pardos-Gea J, et al. Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: A comprehensive review. Autoimmun Rev. 2020;19(7):102569. https://doi.org/10.1016/j.autrev.2020.102569</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cataño-Correa JC, Cardona-Arias JA, Porras Mancilla JP, García MT. Bacterial superinfection in adults with COVID-19 hospitalized in two clinics in Medellín-Colombia, 2020. PLoS One. 2021;16(7):e0254671. https://doi.org/10.1371/journal.pone.0254671</mixed-citation><mixed-citation xml:lang="en">Cataño-Correa JC, Cardona-Arias JA, Porras Mancilla JP, García MT. Bacterial superinfection in adults with COVID-19 hospitalized in two clinics in Medellín-Colombia, 2020. PLoS One. 2021;16(7):e0254671. https://doi.org/10.1371/journal.pone.0254671</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rawson TM, Moore LSP, Zhu N, Ranganathan N, Skolimowska K, et al. Bacterial and Fungal Coinfection in Individuals With Coronavirus: A Rapid Review To Support COVID-19 Antimicrobial Prescribing. Clin Infect Dis. 2020;71(9):2459-2468. https://doi.org/10.1093/cid/ciaa530</mixed-citation><mixed-citation xml:lang="en">Rawson TM, Moore LSP, Zhu N, Ranganathan N, Skolimowska K, et al. Bacterial and Fungal Coinfection in Individuals With Coronavirus: A Rapid Review To Support COVID-19 Antimicrobial Prescribing. Clin Infect Dis. 2020;71(9):2459-2468. https://doi.org/10.1093/cid/ciaa530</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lansbury L, Lim B, Baskaran V, Lim WS. Co-infections in people with COVID-19: a systematic review and meta-analysis. J Infect. 2020;81(2):266-275. https://doi.org/10.1016/j.jinf.2020.05.046</mixed-citation><mixed-citation xml:lang="en">Lansbury L, Lim B, Baskaran V, Lim WS. Co-infections in people with COVID-19: a systematic review and meta-analysis. J Infect. 2020;81(2):266-275. https://doi.org/10.1016/j.jinf.2020.05.046</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Musuuza JS, Watson L, Parmasad V, Putman-Buehler N, Christensen L, Safdar N. Prevalence and outcomes of coinfection and superinfection with SARS-CoV-2 and other pathogens: A systematic review and meta-analysis. PLoS One. 2021;16(5):e0251170. https://doi.org/10.1371/journal.pone.0251170</mixed-citation><mixed-citation xml:lang="en">Musuuza JS, Watson L, Parmasad V, Putman-Buehler N, Christensen L, Safdar N. Prevalence and outcomes of coinfection and superinfection with SARS-CoV-2 and other pathogens: A systematic review and meta-analysis. PLoS One. 2021;16(5):e0251170. https://doi.org/10.1371/journal.pone.0251170</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323(16):1574-1581. Erratum in: JAMA. 2021;325(20):2120. https://doi.org/10.1001/jama.2020.5394</mixed-citation><mixed-citation xml:lang="en">Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323(16):1574-1581. Erratum in: JAMA. 2021;325(20):2120. https://doi.org/10.1001/jama.2020.5394</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Huang C, Wang Y, Li X, Ren L, Zhao J, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. Erratum in: Lancet. 2020;395(10223):496. https://doi.org/10.1016/S0140-6736(20)30183-5</mixed-citation><mixed-citation xml:lang="en">Huang C, Wang Y, Li X, Ren L, Zhao J, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. Erratum in: Lancet. 2020;395(10223):496. https://doi.org/10.1016/S0140-6736(20)30183-5</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rhee C, Baker MA, Klompas M. The COVID-19 infection control arms race. Infect Control Hosp Epidemiol. 2020;41(11):1323-1325. https://doi.org/10.1017/ice.2020.211</mixed-citation><mixed-citation xml:lang="en">Rhee C, Baker MA, Klompas M. The COVID-19 infection control arms race. Infect Control Hosp Epidemiol. 2020;41(11):1323-1325. https://doi.org/10.1017/ice.2020.211</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou P, Liu Z, Chen Y, Xiao Y, Huang X, Fan XG. Bacterial and fungal infections in COVID-19 patients: A matter of concern. Infect Control Hosp Epidemiol. 2020;41(9):1124-1125. https://doi.org/110.1017/ice.2020.156</mixed-citation><mixed-citation xml:lang="en">Zhou P, Liu Z, Chen Y, Xiao Y, Huang X, Fan XG. Bacterial and fungal infections in COVID-19 patients: A matter of concern. Infect Control Hosp Epidemiol. 2020;41(9):1124-1125. https://doi.org/110.1017/ice.2020.156</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Giacobbe DR, Battaglini D, Ball L, Brunetti I, Bruzzone B, et al. Bloodstream infections in critically ill patients with COVID-19. Eur J Clin Invest. 2020;50(10):e13319. https://doi.org/10.1111/eci.13319</mixed-citation><mixed-citation xml:lang="en">Giacobbe DR, Battaglini D, Ball L, Brunetti I, Bruzzone B, et al. Bloodstream infections in critically ill patients with COVID-19. Eur J Clin Invest. 2020;50(10):e13319. https://doi.org/10.1111/eci.13319</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Dudoignon E, Caméléna F, Deniau B, Habay A, Coutrot M, et al. Bacterial Pneumonia in COVID-19 Critically Ill Patients: A Case Series. Clin Infect Dis. 2021;72(5):905-906. Medical Herald of the South of Russia107 2026; 17(2):104-108 https://doi.org/10.1093/cid/ciaa762</mixed-citation><mixed-citation xml:lang="en">Dudoignon E, Caméléna F, Deniau B, Habay A, Coutrot M, et al. Bacterial Pneumonia in COVID-19 Critically Ill Patients: A Case Series. Clin Infect Dis. 2021;72(5):905-906. Medical Herald of the South of Russia107 2026; 17(2):104-108 https://doi.org/10.1093/cid/ciaa762</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sharifipour E, Shams S, Esmkhani M, Khodadadi J, FotouhiArdakani R, et al. Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU. BMC Infect Dis. 2020;20(1):646. https://doi.org/10.1186/s12879-020-05374-z</mixed-citation><mixed-citation xml:lang="en">Sharifipour E, Shams S, Esmkhani M, Khodadadi J, FotouhiArdakani R, et al. Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU. BMC Infect Dis. 2020;20(1):646. https://doi.org/10.1186/s12879-020-05374-z</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Seligman R, Ramos-Lima LF, Oliveira Vdo A, Sanvicente C, Sartori J, Pacheco EF. Risk factors for infection with multidrugresistant bacteria in non-ventilated patients with hospitalacquired pneumonia. J Bras Pneumol. 2013;39(3):339-348. https://doi.org/10.1590/S1806-37132013000300011</mixed-citation><mixed-citation xml:lang="en">Seligman R, Ramos-Lima LF, Oliveira Vdo A, Sanvicente C, Sartori J, Pacheco EF. Risk factors for infection with multidrugresistant bacteria in non-ventilated patients with hospitalacquired pneumonia. J Bras Pneumol. 2013;39(3):339-348. https://doi.org/10.1590/S1806-37132013000300011</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Li H, Liu L, Zhang D, Xu J, Dai H, et al. SARS-CoV-2 and viral sepsis: observations and hypotheses. Lancet. 2020;395(10235):1517-1520. https://doi.org/10.1016/S0140-6736(20)30920-X</mixed-citation><mixed-citation xml:lang="en">Li H, Liu L, Zhang D, Xu J, Dai H, et al. SARS-CoV-2 and viral sepsis: observations and hypotheses. Lancet. 2020;395(10235):1517-1520. https://doi.org/10.1016/S0140-6736(20)30920-X</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bartoletti M, Pascale R, Cricca M, Rinaldi M, Maccaro A, et al. Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study. Clin Infect Dis. 2021;73(11):e3606-e3614. https://doi.org/10.1093/cid/ciaa1065</mixed-citation><mixed-citation xml:lang="en">Bartoletti M, Pascale R, Cricca M, Rinaldi M, Maccaro A, et al. Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study. Clin Infect Dis. 2021;73(11):e3606-e3614. https://doi.org/10.1093/cid/ciaa1065</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Dananché C, Vanhems P, Machut A, Aupée M, Bervas C, et al. Trends of Incidence and Risk Factors of Ventilator-Associated Pneumonia in Elderly Patients Admitted to French ICUs Between 2007 and 2014. Crit Care Med. 2018;46(6):869-877. https://doi.org/10.1097/CCM.0000000000003019</mixed-citation><mixed-citation xml:lang="en">Dananché C, Vanhems P, Machut A, Aupée M, Bervas C, et al. Trends of Incidence and Risk Factors of Ventilator-Associated Pneumonia in Elderly Patients Admitted to French ICUs Between 2007 and 2014. Crit Care Med. 2018;46(6):869-877. https://doi.org/10.1097/CCM.0000000000003019</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lipsky MS, Hung M. Men and COVID-19: A Pathophysiologic Review. Am J Mens Health. 2020;14(5):1557988320954021. https://doi.org/10.1177/1557988320954021</mixed-citation><mixed-citation xml:lang="en">Lipsky MS, Hung M. Men and COVID-19: A Pathophysiologic Review. Am J Mens Health. 2020;14(5):1557988320954021. https://doi.org/10.1177/1557988320954021</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Parekh D, Patel JM, Scott A, Lax S, Dancer RC, et al. Vitamin D Deficiency in Human and Murine Sepsis. Crit Care Med. 2017;45(2):282-289. https://doi.org/10.1097/CCM.0000000000002095</mixed-citation><mixed-citation xml:lang="en">Parekh D, Patel JM, Scott A, Lax S, Dancer RC, et al. Vitamin D Deficiency in Human and Murine Sepsis. Crit Care Med. 2017;45(2):282-289. https://doi.org/10.1097/CCM.0000000000002095</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Bychinin MV, Klypa TV, Mandel IA, Andreichenko SA, Baklaushev VP, et al. Low Circulating Vitamin D in Intensive Care Unit-Admitted COVID-19 Patients as a Predictor of Negative Outcomes. J Nutr. 2021;151(8):2199-2205. https://doi.org/10.1093/jn/nxab107</mixed-citation><mixed-citation xml:lang="en">Bychinin MV, Klypa TV, Mandel IA, Andreichenko SA, Baklaushev VP, et al. Low Circulating Vitamin D in Intensive Care Unit-Admitted COVID-19 Patients as a Predictor of Negative Outcomes. J Nutr. 2021;151(8):2199-2205. https://doi.org/10.1093/jn/nxab107</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">RECOVERY Collaborative Group; Horby P, Lim WS, Emberson JR, Mafham M, et al. Dexamethasone in Hospitalized Patients with Covid-19. N Engl J Med. 2021;384(8):693-704. https://doi.org/10.1056/NEJMoa2021436</mixed-citation><mixed-citation xml:lang="en">RECOVERY Collaborative Group; Horby P, Lim WS, Emberson JR, Mafham M, et al. Dexamethasone in Hospitalized Patients with Covid-19. N Engl J Med. 2021;384(8):693-704. https://doi.org/10.1056/NEJMoa2021436 26. Bardi T, Pintado V, Gomez-Rojo M, Escudero-Sanchez R, Azzam Lopez A, et al. Nosocomial infections associated to COVID-19 in the intensive care unit: clinical characteristics and outcome. Eur J Clin Microbiol Infect Dis. 2021;40(3):495-502. https://doi.org/10.1007/s10096-020-04142-w</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bardi T, Pintado V, Gomez-Rojo M, Escudero-Sanchez R, Azzam Lopez A, et al. Nosocomial infections associated to COVID-19 in the intensive care unit: clinical characteristics and outcome. Eur J Clin Microbiol Infect Dis. 2021;40(3):495-502. https://doi.org/10.1007/s10096-020-04142-w</mixed-citation><mixed-citation xml:lang="en">Bardi T, Pintado V, Gomez-Rojo M, Escudero-Sanchez R, Azzam Lopez A, et al. Nosocomial infections associated to COVID-19 in the intensive care unit: clinical characteristics and outcome. Eur J Clin Microbiol Infect Dis. 2021;40(3):495-502. https://doi.org/10.1007/s10096-020-04142-w</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
