mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2025-16-4-55-61mvjr-2134Research ArticleВНУТРЕННИЕ БОЛЕЗНИINTERNAL DISEASESСердечно-сосудистые заболевания и злокачественные новообразования — что общего?Cardiovascular diseases and malignant neoplasms — what do they have in common?https://orcid.org/0000-0003-2193-7372ШлыкИ. Ф.ShlykI. F.

Шлык Ирина Федоровна, д.м.н., доцент, заведующий кафедрой поликлинической и неотложной терапии

Ростов-на-Дону

Irina F. Shlyk, Dr. Sci. (Med.), Associate Professor, Head of the Department of Outpatient and Emergency Therapy

Rostov-on-Don

sushkinaif@mail.ruhttps://orcid.org/0009-0003-8278-5955КечкинаВ. Д.KechkinaV. D.

Кечкина Виктория Дмитриевна, студент 6 курса лечебно-профилактического факультета 

Ростов-на-Дону

Victoria D. Kechkina, 6th-year student of the Faculty of General Medicine

Rostov-on-Don

vicktoriakechkina@yandex.ruhttps://orcid.org/0000-0003-1396-627XБесединаД. Ю.BesedinaD. Yu.

Беседина Дарья Юрьевна, ассистент кафедры поликлинической и неотложной терапии

Ростов-на-Дону

Daria Yu. Besedina, Assistant, Department of Outpatient and Emergency Therapy

Rostov-on-Don

besedinad@icloud.comРостовский государственный медицинский университетРоссияRostov State Medical UniversityRussian Federation2025211220251645561Copyright © Шлык И.Ф., Кечкина В.Д., Беседина Д.Ю., 20252025Шлык И.Ф., Кечкина В.Д., Беседина Д.Ю.Shlyk I.F., Kechkina V.D., Besedina D.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/2134

Сердечно-сосудистые заболевания как злокачественные новообразования занимают лидирующие позиции в структуре общей смертности. Одним из распространённых побочных эффектов лечения злокачественных новообразований является кардиотоксичность, которая в последующем осложняет патогенетическую терапию образования. Целью данного обзора явилось обобщение и уточнение имеющихся представлений о влиянии различных факторов риска сердечно-сосудистых заболеваний на возникновение рака. Представленный обзор позволяет детально изучить результаты метаанализов и крупномасштабных исследований, дополняющие представление о классических поведенческих факторах, таких как курение, употребление алкоголя, нерациональное питание, и биологических факторах риска, таких как артериальная гипертензия, ожирение, сахарный диабет, отражающие вклад этих факторов в развитие не только сердечно-сосудистых, но и злокачественных новообразований. Влияние данных факторов, проанализировано с позиции патогенетических механизмов — оксидативного стресса и хронического воспаления, кардиотоксичности проводимого лечения. Также в обзоре уделяется внимание противоречивым данным в отношении влияния какого-либо фактора на возникновение данных нозологий и обобщается анализируемый материал.

Cardiovascular diseases, as malignant neoplasms, occupy a leading position in the structure of total mortality. One of the common side effects of the treatment of malignant neoplasms is cardiotoxicity, which subsequently complicates the pathogenetic therapy of the formation. The purpose of this review was to summarize and clarify existing ideas about the influence of various risk factors for cardiovascular diseases on the occurrence of cancer. The presented review allows us to study in detail the results of meta–analyses and large-scale studies that complement the understanding of classical behavioral factors such as smoking, alcohol consumption, poor nutrition and biological risk factors such as hypertension, obesity, diabetes mellitus, reflecting the contribution of these factors not only to the development of cardiovascular diseases, but also malignant neoplasms. The influence of these factors was analyzed from the perspective of pathogenetic mechanisms – oxidative stress and chronic inflammation, cardiotoxicity of the treatment. The review also focuses on contradictory data regarding the influence of any factor on the occurrence of these nosologies and summarizes the analyzed material.

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The authors declare that there are no conflicts of interest present.