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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2219-8075-2025-16-4-41-46</article-id><article-id custom-type="elpub" pub-id-type="custom">mvjr-2133</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВНУТРЕННИЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Клинический случай летального исхода инфекционного эндокардита у пациента с опиатной зависимостью</article-title><trans-title-group xml:lang="en"><trans-title>Clinical case of infectious endocarditis fatal outcome in a patient with opiate addiction</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2872-090X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вавилина</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Vavilina</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вавилина Елена Сергеевна, к.м.н., доцент кафедры внутренних болезней №1</p><p>г. Курск</p></bio><bio xml:lang="en"><p>Elena S. Vavilina, Cand. Sci. (Med.), Associate Professor of the Department of Internal Diseases N 1</p><p>Kursk</p></bio><email xlink:type="simple">vavilinals@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9292-3093</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мещерина</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Meshcherina</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мещерина Наталья Сергеевна, д.м.н., заведующая кафедрой внутренних болезней №1, проректор по медицинской деятельности и развитию регионального здравоохранения</p><p>г. Курск</p></bio><bio xml:lang="en"><p>Natalia S. Meshcherina, Dr. Sci. (Med.), Associate Professor, The Head of the Department оf Internal Diseases №1, Vice-Rector for Medical Activities and Development of Regional Healthcare</p><p>Kursk</p></bio><email xlink:type="simple">n.mescherina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-2309-7821</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаталова</surname><given-names>О. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Schatalova</surname><given-names>O. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шаталова Ольга Геннадьевна, студентка 6 курса педиатрического факультета</p><p>г. Курск</p></bio><bio xml:lang="en"><p>Olga G. Schatalova, 6-year student of pediatric faculty</p><p>Kursk</p></bio><email xlink:type="simple">olia.schatalova2016@yandex.ru093</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Курский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kursk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>21</day><month>12</month><year>2025</year></pub-date><volume>16</volume><issue>4</issue><fpage>41</fpage><lpage>46</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Вавилина Е.С., Мещерина Н.С., Шаталова О.Г., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Вавилина Е.С., Мещерина Н.С., Шаталова О.Г.</copyright-holder><copyright-holder xml:lang="en">Vavilina E.S., Meshcherina N.S., Schatalova O.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/2133">https://www.medicalherald.ru/jour/article/view/2133</self-uri><abstract><p>Инфекционный эндокардит (ИЭ) потребителей инъекционных наркотиков (ПИН) остается нерешённой и весьма значимой медико-социальной проблемой в связи со стремительным ростом числа наркозависимых пациентов, высокой частотой осложнений и госпитальной летальности, что обусловливает актуальность поиска их предикторов, требует оптимизации лечения с целью улучшения прогноза у данной категории больных. В статье продемонстрировано собственное клиническое наблюдение молодого пациента (ПИН) с первичным ИЭ с формированием сочетанного аортального порока, абсцесса синуса Вальсальвы и его прорыва в полость правого желудочка с развитием острой декомпенсации сердечной деятельности, полиорганной недостаточности, фибрилляции желудочков, что привело к смерти пациента. Ввиду крайне тяжёлого состояния больного не представлялось возможным своевременно транспортировать его в кардиохирургический центр для оперативного лечения. Обсуждены наиболее вероятные причины осложнений и летального исхода, возможности их предупреждения.</p></abstract><trans-abstract xml:lang="en"><p>Infectious endocarditis (IE) of injecting drug users (IDU) remains an unresolved and very significant medical and social problem due to the rapid increase in the number of drug-addicted patients, high frequency of complications and hospital mortality, which determines the relevance of the search for their predictors, requires optimization of treatment in order to improve the prognosis in this category of patients. The article demonstrates our own clinical observation of a young IDU patient with primary IE and the formation of a combined aortic defect, Valsalva sinus abscess and its rupture into the right ventricular cavity with the development of acute cardiac activity decompensation, multiple organ failure, ventricular fibrillation, which led to the death of the patient. In view of the extremely serious condition of the patient, it was not possible to timely transport him to a cardiac surgery center for surgical treatment. The most probable causes of complications and death, as well as the possibilities of their prevention, are discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекционный эндокардит</kwd><kwd>потребители инъекционных наркотических препаратов</kwd><kwd>абсцесс синуса Вальсальвы</kwd><kwd>летальный исход</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infectious endocarditis</kwd><kwd>injecting drug users</kwd><kwd>Valsalva sinus abscess</kwd><kwd>fatal outcome</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование не имело спонсорской поддержки.</funding-statement><funding-statement xml:lang="en">The study did not have sponsorship.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Демин А.А., Кобалава Ж.Д., Скопин И.И., Тюрин В.П., Бойцов С.А., и др. Инфекционный эндокардит и инфекция внутрисердечных устройств. 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