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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2219-8075-2025-16-4-47-54</article-id><article-id custom-type="elpub" pub-id-type="custom">mvjr-2118</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВНУТРЕННИЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Клинико-морфологические особенности мантийноклеточной лимфомы как причины асцита</article-title><trans-title-group xml:lang="en"><trans-title>Clinical and morphological features of mantle cell lymphoma as a cause of ascites</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5749-5524</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сердюк</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Serdyuk</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сердюк Анна Андреевна, к.м.н., ассистент кафедры госпитальной терапии; врач-терапевт</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Anna A. Serdyuk, Cand. Sci. (Med.), Assistant Professor at the Department of Hospital Therapy; Therapist</p><p>Krasnodar</p></bio><email xlink:type="simple">xapzyann@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-2559-1673</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ларионова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Larionova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ларионова Анна Владимировна, врач клинической лабораторной диагностики</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Anna A. Serdyuk, Cand. Sci. (Med.), Assistant Professor at the Department of Hospital Therapy</p><p>Krasnodar</p></bio><email xlink:type="simple">loran41@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4909-5963</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рабаданов</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rabadanov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рабаданов Даниил Аликадиевич, ассистент кафедры госпитальной терапии; врач-терапевт</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Daniil A. Rabadanov, Assistant Professor at the Department of Hospital Therapy; Therapist</p><p>Krasnodar</p></bio><email xlink:type="simple">daniilrabadanov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9064-8617</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чухрай</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Chukhrai</surname><given-names>O. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чухрай Ольга Юрьевна, заведующая патологоанатомическим отделением</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Olga Yu. Chukhray, Head of the Pathology Department</p><p>Krasnodar</p></bio><email xlink:type="simple">sdocer@rambler.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9390-9154</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Читанава</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chitanava</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Читанава Тамара Вангельевна, к.м.н., врач-гематолог</p></bio><bio xml:lang="en"><p>Tamara V. Chitanava, Cand. Sci. (Med.), Hematologist</p><p>Krasnodar</p></bio><email xlink:type="simple">chitanava.tamara@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кубанский государственный медицинский университет; Краевая клиническая больница скорой медицинской помощи</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University; Krasnodar Regional Clinical Emergency Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Краевая клиническая больница скорой медицинской помощи</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Krasnodar Regional Clinical Emergency Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Клинический онкологический диспансер №1</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinical Oncology Dispensary No. 1</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>21</day><month>12</month><year>2025</year></pub-date><volume>16</volume><issue>4</issue><fpage>47</fpage><lpage>54</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сердюк А.А., Ларионова А.В., Рабаданов Д.А., Чухрай О.Ю., Читанава Т.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Сердюк А.А., Ларионова А.В., Рабаданов Д.А., Чухрай О.Ю., Читанава Т.В.</copyright-holder><copyright-holder xml:lang="en">Serdyuk A.A., Larionova A.V., Rabadanov D.A., Chukhrai O.Y., Chitanava T.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/2118">https://www.medicalherald.ru/jour/article/view/2118</self-uri><abstract><p>В статье представлено описание редкого клинического случая развития гидроперитонеума у пациента с мантийноклеточной лимфомой. Данное наблюдение иллюстрирует диагностические сложности при выявлении причины асцита неясной этиологии и подчеркивает важную роль цитологического анализа асцитической жидкости.</p><p>Мантийноклеточная лимфома — это агрессивная зрелая В-клеточная лимфома, характеризующаяся пролиферацией аномальных лимфоидных клеток с типичными индолентными ядерными контурами. Хотя экстранодальное поражение для данного вида лимфомы не редкость, изолированное возникновение асцита как первого проявления заболевания представляет собой уникальную и сложную диагностическую ситуацию.</p><p>Целью данного клинического примера явилась демонстрация важности включения онкологических и гематологических заболеваний в дифференциально-диагностический поиск при асците, особенно когда стандартные методы (например, визуализирующие методы диагностики, биохимические тесты) не выявляют очевидной причины.</p><p>В работе детально разбирается клинический случай пациента с гидроперитонеумом, где был применен комплексный диагностический подход, включая ультразвуковое исследование, лабораторные анализы и, что наиболее важно, — цитологическое и иммунофенотипическое исследование перитонеальной жидкости.</p><p>Цитологический анализ асцитической жидкости выявил наличие атипичных лимфоидных клеток, что позволило установить диагноз мантийноклеточной лимфомы с поражением брюшины. Этот метод диагностики стал ключевым для определения тактики ведения пациента и своевременного начала специфической полихимиотерапии.</p><p>Раннее выявление специфических клеток в асцитической жидкости позволяет установить точный диагноз, определить стадию заболевания и незамедлительно начать соответствующее лечение, что в конечном итоге улучшает прогноз для пациента.</p></abstract><trans-abstract xml:lang="en"><p>The article describes a rare clinical case of hydroperitoneum in a patient with mantle cell lymphoma. This observation illustrates the diagnostic difficulties in identifying the cause of ascites of unclear etiology and emphasizes the important role of cytological analysis of ascitic fluid.</p><p>Mantle cell lymphoma is an aggressive mature B-cell lymphoma characterized by the proliferation of abnormal lymphoid cells with typical indolent nuclear circuits. Although extranodal involvement is not uncommon for a given vila lymphoma, the isolated occurrence of ascites as the first manifestation of the disease presents a unique and complex diagnostic situation.</p><p>The purpose of this clinical example was to demonstrate the importance of including oncological and hematological diseases in the differential diagnostic search for ascites, especially when standard methods (for example, imaging diagnostic methods, biochemical tests) do not reveal an obvious cause.</p><p>The work analyzes in detail the clinical case of a patient with hydroperitoneum, where a comprehensive diagnostic approach was applied, including ultrasound examination, laboratory tests and, most importantly, cytological and immunophenotypic examination of peritoneal fluid.</p><p>Cytological analysis of ascitic fluid revealed the presence of atypical lymphoid cells, which made it possible to establish the diagnosis of mantle cell lymphoma with peritoneal damage. This diagnostic method has become key for determining the tactics of patient management and the timely start of specific polychemotherapy.</p><p> Early detection of specific cells in ascitic fluid allows for an accurate diagnosis, determination of the stage of the disease and immediate initiation of appropriate treatment, ultimately improving the prognosis for the patient.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>асцит</kwd><kwd>мантийноклеточная лимфома</kwd><kwd>цитологический анализ асцитической жидкости</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ascites</kwd><kwd>mantle cell lymphoma</kwd><kwd>cytological analysis of ascitic fluid</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование не имело спонсорской поддержки.</funding-statement><funding-statement xml:lang="en">The study did not have sponsorship.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Argatoff LH, Connors JM, Klasa RJ, Horsman DE, Gascoyne RD. 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