mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2025-16-4-35-40mvjr-2116Research ArticleВНУТРЕННИЕ БОЛЕЗНИINTERNAL DISEASESНетипичный случай развития системной красной волчанки у мужчины старше 50 летAn atypical case of systemic lupus erythematosus in a male over 50https://orcid.org/0000-0002-9220-5841БлагининаИ. И.BlagininaI. I.

Благинина Ирина Ивановна, к.м.н., доцент, доцент кафедры внутренней медицины

Луганск

Irina I. Blaginina, Cand. Sci. (Med.), Associate Professor; Associate professor, Department of internal medicine

Lugansk

barry1803irina@yandex.ruhttps://orcid.org/0000-0002-8953-1048БлагодаренкоА. Б.BlagodarenkoA. B.

Благодаренко Анна Борисовна, к.м.н., доцент кафедры внутренней медицины

Луганск

Anna B. Blagodarenko, Cand. Sci. (Med.), Associate professor, Department of internal medicine

Lugansk

aborisovna3@mail.ruБахтояровП. Д.BakhtoyarovP. D.

Бахтояров Павел Дмитриевич, к.м.н., доцент, доцент кафедры нервных болезней и нейрохирургии

Луганск

Pavel D. Bakhtoyarov, Cand. Sci. (Med.), Associate Professor; Associate professor, Department of Nervous Diseases and Neurosurgery

Lugansk

shaoyan@yandex.ruЛуганский государственный медицинский университет имени Святителя ЛукиЛНРLugansk State Medical University n. a. St. LukeLNR2025211220251643540Copyright © Благинина И.И., Благодаренко А.Б., Бахтояров П.Д., 20252025Благинина И.И., Благодаренко А.Б., Бахтояров П.Д.Blaginina I.I., Blagodarenko A.B., Bakhtoyarov P.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/2116

Системная красная волчанка (СКВ) — хроническое системное аутоиммунное заболевание неизвестной этиологии с поражением соединительной ткани и сосудов, развивающееся на фоне несовершенства иммунорегуляторных процессов. Представлен клинический случай, демонстрирующий развитие СКВ у пациента мужского пола в возрасте старше 50 лет. От 2 до 20% случаев дебюта СКВ приходится на возрастной период старше 50 лет. Прогностически неблагоприятными факторами течения СКВ у лиц пожилого возраста являются поражение нервной системы, часто сопровождающееся развитием нейропсихических расстройств, и осложняющееся развитием острого нарушения мозгового кровообращения, дислипидемии, сахарный диабет. У мужчин с СКВ с высокой частотой встречаются серозиты, тромбозы, цитопении, высокий титр антител к фосфолипидам. Нетипичное начало заболевания, неполное соответствие диагностическим критериям, недостаточная осведомлённость врачей о возможности развития СКВ у лиц старшего возраста и, особенно, мужского пола, явились причинами позднего установления диагноза в представленном нами клиническом случае. В подобных случаях для более ранней диагностики обоснованным является междисциплинарный подход и сотрудничество врачей различных специальностей с использованием всех доступных лабораторно-инструментальных методов обследования.

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with unknown etiology that affects connective tissue and blood vessels. It develops due to imperfect immunoregulatory processes. A clinical case of SLE in a male patient aged over 50 will be presented. This condition is rare, with 2-20% of cases occurring in this age group. The prognosis for SLE in elderly patients is often unfavorable, as it can lead to damage to the nervous system and the development of neuropsychiatric disorders. This can be complicated by acute cerebral circulatory disorders, dyslipidemia, and diabetes.In men with SLE, serositis, thrombosis, cytopenia, and high titer of antibodies to phospholipids occur with high frequency. The atypical onset of the disease, incomplete compliance with diagnostic criteria, and insufficient awareness among doctors about the possibility of developing SLE in older people and, especially, males, were the reasons for the late diagnosis in the clinical case presented by us. In such cases, an interdisciplinary approach and collaboration of doctors of various specialties using all available laboratory and instrumental examination methods are reasonable for earlier diagnosis.

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The authors declare that there are no conflicts of interest present.