mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2025-16-4-74-83mvjr-2073Research ArticleИНФЕКЦИОННЫЕ БОЛЕЗНИINFECTIOUS DISEASESСовременные направления изучения средств неспецифической профилактики холерыModern approaches to studying non-specific prevention of cholerahttps://orcid.org/0000-0002-1103-4244ФилиппенкоА. В.FilippenkoA. V.

Филиппенко Анна Владимировна, к.б.н., научный сотрудник лаборатории иммунологии

Ростов-на-Дону

Anna V. Filippenko, Cand. Sci. (Biology), Research Laboratory of Immunology

Rostov-on-Don

filippenko.annushka@mail.ruhttps://orcid.org/0000-0001-7068-4071ИвановаИ. ИIvanovaI. A.

Иванова Инна Александровна, к.б.н., ведущий научный сотрудник, и.о. зав. лабораторией иммунологии

Ростов-на-Дону

Inna A. Ivanova, Cand. Sci. (Biology), Leading Researcher with Acting Head of the Laboratory Immunology

Rostov-on-Don

ivanova_ia@antiplague.ruhttps://orcid.org/0000-0001-5208-7724ОмельченкоН. Д.OmelchenkoN. D.

Омельченко Наталья Дмитриевна, к.м.н., старший научный сотрудник лаборатории иммунологии

Ростов-на-Дону

Natalia D. Omelchenko, Cand. Sci. (Med.), Senior Researcher Laboratory of Immunology

Rostov-on-Don

natalya.omelchenko@yandex.ruhttps://orcid.org/0000-0002-4770-5994ТруфановаА. Д.TrufanovaA. A.

Труфанова Анастасия Александровна, младший научный сотрудник лаборатории иммунологии

Ростов-на-Дону

Anastasia A. Trufanova, Junior Researcher, Laboratory of Immunology

Rostov-on-Don

nastyasia61@mail.ruhttps://orcid.org/0009-0008-3926-8182ЖуковаО. Г.ZhukovaO. G.

Жукова Ольга Геннадьевна, младший научный сотрудник лаборатории иммунологии

Ростов-на-Дону

Olga G. Zhukova, Junior Researcher at the Laboratory of Immunology

Rostov-on-Don

zhuova_og@antiplague.ruРостовский-на-Дону противочумный институт РоспотребнадзораРоссияRostov-on-Don Anti-Plague Institute of RospotrebnadzorRussian Federation2025211220251647483Copyright © Филиппенко А.В., Иванова И.И., Омельченко Н.Д., Труфанова А.Д., Жукова О.Г., 20252025Филиппенко А.В., Иванова И.И., Омельченко Н.Д., Труфанова А.Д., Жукова О.Г.Filippenko A.V., Ivanova I.A., Omelchenko N.D., Trufanova A.A., Zhukova O.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/2073

Холера остается серьезной проблемой общественного здравоохранения, особенно в странах с низким уровнем доходов, отсутствием водоснабжения и санитарно-просветительного образования среди населения. Вакцинация на сегодняшний день является основной мерой профилактики этой инфекции в эндемичных районах и во время вспышек, однако по ряду причин её эффективность может снижаться: всегда есть группа лиц, имеющих противопоказания к проведению вакцинации и не отвечающих на вакцину. Кроме того, существуют проблемы с доставкой, хранением и транспортировкой вакцинных препаратов. Все эти факторы обусловливают необходимость поиска, разработки и внедрения различных новых средств, препятствующих распространению заболевания. Целью данного обзора являлся анализ литературных данных, посвящённых изучению возможности использования антибиотиков, бактериофагов, пробиотических микроорганизмов, растительных компонентов и других веществ, для профилактики холеры. Список литературы включает 56 источников за последние десять лет, взятых из баз данных «РИНЦ», «eLibrary», «MedLine», «PubMed».

Cholera remains a serious public health problem, especially in low-income countries with a lack of water supply and sanitation education among the population. Vaccination is currently the main measure to prevent this infection in endemic areas and during outbreaks, but for a number of reasons its effectiveness may decrease: there is always a group of people who have contraindications to vaccination and do not respond to the vaccine. In addition, there are problems with the delivery, storage and transportation of vaccine preparations. All these factors necessitate the search, development and implementation of various new means to prevent the spread of the disease. The purpose of this review was to analyze the literature data on the study of the possibility of using antibiotics, bacteriophages, probiotic microorganisms, plant components and other substances for the prevention of cholera. The list of references includes 56 sources for the last ten years, taken from databases: RSCI, eLibrary, MedLine, PubMed.

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The authors declare that there are no conflicts of interest present.