mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2024-15-4-90-98mvjr-2018Research ArticleАЛЛЕРГОЛОГИЯ И ИММУНОЛОГИЯALLERGOLOGY AND IMMUNOLOGYВрождённый иммунный ответ — ключевой игрок в процессе кальциноза коронарных артерий и аортального клапанаThe innate immune response is a key player in the process of coronary artery and aortic valve calcificationhttps://orcid.org/0000-0003-2193-7372ШлыкИ. Ф.ShlykI. F.

Ирина Федоровна Шлык, д.м.н., доцент, профессор кафедры кардиологии, ревматологии и функциональной диагностики

Ростов-на-Дону, Россия

Irina F. Shlyk, Dr. Sci. (Med.), Associate Professor, Professor of the Department of Cardiology, Rheumatology and Functional Diagnostics

Rostov-on-Don

sushkinaif@mail.ruhttps://orcid.org/0000-0003-0806-6437ХаритоноваМ. В.KharitonovaM. V.

Мария Владимировна Харитонова, к.м.н., заведующая лабораторией клинической иммунологии и аллергологии

Ростов-на-Дону

Maria V. Kharitonova, Cand. Sci. (Med.), Head of the Laboratory of Clinical Immunology and Allergology

Rostov-on-Don

mari.kharitonova.80@mail.ruhttps://orcid.org/0000-0002-6238-9782МоргуновМ. Н.MorgunovM. N.

Максим Николаевич Моргунов, к.м.н., доцент кафедры ультразвуковой диагностики

Ростов-на-Дону

Maxim N. Morgunov, Cand. Sci. (Med.), Associate Professor at the Diagnostic Ultrasound Department

Rostov-on-Don

doc.max@mail.ruhttps://orcid.org/0000-0003-3116-0560БлиновИ. М.BlinovI. M.

Блинов Игорь Михайлович, врач-рентгенолог отделения магнитно-резонансной и рентгеновской компьютерной томографии

Ростов-на-Дону

Igor M. Blinov, Radiologist of the Department of Magnetic Resonance and x-ray Computed Tomography

Rostov-on-Don

bim-bim@mail.ruhttps://orcid.org/0000-0002-1026-7492ВасильеваЕ. Д.VasilyevaE. D.

Елизавета Дмитриевна Васильева, ординатор кафедры лучевой диагностики

Ростов-на-Дону

Elizaveta D. Vasilyeva, resident of the Department of Radiation Diagnostics

Rostov-on-Don

el.stefanova2015@yandex.ruhttps://orcid.org/0000-0003-1396-627XБесединаД. Ю.BesedinaD. Yu.

Дарья Юрьевна Беседина, ассистент кафедры поликлинической терапии

Ростов-на-Дону

Daria Yu. Besedina, Assistant, Department of Polyclinic Therapy

Rostov-on-Don

besedinad@icloud.comРостовский государственный медицинский университетРоссияRostov State Medical UniversityRussian Federation2024171020241549098Copyright © Шлык И.Ф., Харитонова М.В., Моргунов М.Н., Блинов И.М., Васильева Е.Д., Беседина Д.Ю., 20242024Шлык И.Ф., Харитонова М.В., Моргунов М.Н., Блинов И.М., Васильева Е.Д., Беседина Д.Ю.Shlyk I.F., Kharitonova M.V., Morgunov M.N., Blinov I.M., Vasilyeva E.D., Besedina D.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/2018

Представленный обзор литературы позволяет понять и дополнить имеющиеся представления о патогенезе коронарного кальциноза и кальциноза аортального клапана на этапе формирования этих изменений, детально исследовать участие наиболее изученных иммунокомпетентных клеток врождённого иммунитета, таких как макрофаги, дендритные и тучные клетки, нейтрофилов, натуральных киллеров в кальцификации артерий и аортального клапана, их функциональную роль в прогрессировании этого процесса. Также в обзоре представлены пробелы и недостающие данные, присутствующие в изучении данных клеточных популяций, восполнение которых внесёт вклад в разработку таргетной терапии процесса кальцификации.

Поиск источников литературы проведён в следующих базах данных: «Scopus», «web of Science», «MedLine», «The Cochrane Library», «РИНЦ», «Springer», «Science Direct» — с учётом года публикации (не более 10 лет), языка публикации (английский/русский), наличия полнотекстовых публикаций и доступа к ним.

The presented literature review allows us to understand and supplement the existing ideas about the pathogenesis of coronary calcification and aortic valve calcification at the stage of formation of these changes. To study in detail the participation of the most studied immunocompetent cells of innate immunity, such as macrophages, dendritic and mast cells, neutrophils, natural killers in calcification of arteries and aortic valve, their functional role in the progression of this process. The review also presents gaps and missing data present in the study of these cell populations, the replenishment of which will contribute to the development of targeted therapy for the calcification process.

The search for literature sources was conducted in the following databases: Scopus, web of Science, MedLine, The Cochrane Library, RSCI, Springer, Science Direct — taking into account the year of publication (no more than 10 years), language of publication (English/Russian), availability of full-text publications and access to them.

врождённый иммунный ответкоронарный кальцинозкальциноз аортального клапанамакрофагидендритные клеткитучные клеткиinnate immune responsecoronary calcificationaortic valve calcificationmacrophagesdendritic cellsmast cellsОбзорная статья выполнена в рамках государственного задания по научной теме «Иммунологические и биохимические предикторы кальциноза коронарных артерий, патогенетическое обоснование тяжести его течения и создание инструментов прогнозирования сердечно-сосудистого риска» 1023022000034-7-3.1.3;3.2.4 от 31.05.2024, утвержденная Министерством здравоохранения РФ.The review article was carried out within the framework of the state assignment on the scientific topic “Immunological and biochemical predictors of coronary artery calcification, pathogenetic substantiation of the severity of its course and the creation of tools for predicting cardiovascular risk” 1023022000034-7-3.1.3;3.2.4 dated 05/31/2024 approved by the Ministry healthcare of the Russian Federation.ReferencesБарбараш О.Л., Кашталап В.В., Шибанова И.А., Коков А.Н. 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The authors declare that there are no conflicts of interest present.