mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2025-16-1-5-13mvjr-2004Research Article3.1.4. АКУШЕРСТВО И ГИНЕКОЛОГИЯ3.1.4. OBSTETRICS AND GYNECOLOGYПроблема рецидива эндометриом яичникаThe problem of recurrence of ovarian endometriomashttps://orcid.org/0000-0003-2228-3884ЦхайВ. Б.TskhayV. B.

 Цхай Виталий Борисович, д.м.н., профессор, заведующий кафедрой перинатологии, акушерства и гинекологии лечебного факультета; научный консультант 

Красноярск

 Vitaly B. Tskhay, Dr. Sci. (Med.), Professor, Head of the Department of Perinatology, Obstetrics and Gynecology; Scientific consultant 

 Krasnoyarsk 

tchai@yandex.ruhttps://orcid.org/0000-0003-4462-4109ГребенниковаЭ. К.GrebennikovaE. K.

 Гребенникова Эльвира Константиновна, к.м.н., доцент кафедры перинатологии, акушерства и гинекологии 

Красноярск

 Elvira K. Grebennikova, Cand. Sci. (Med.), Associate Professor of the Department of Perinatology, Obstetrics and Gynecology 

 Krasnoyarsk 

ilay_m@mail.ruhttps://orcid.org/0000-0002-4357-6793СкуратоваЮ. Н.SkuratovaJu. N.

 Скуратова Юлия Николаевна, ассистент кафедры перинатологии, акушерства и гинекологии  

Красноярск

 Yulia N. Skuratova, Assistant at the Department of Perinatology, Obstetrics and Gynecology 

 Krasnoyarsk 

skuratova-julia@yandex.ruКрасноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого; Федеральный Сибирский научно-клинический центр Федерального медико-биологического агентства РоссииРоссияProf. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Federal Siberian Research Clinical Centre, Federal Medical-Biological AgencyRussian FederationКрасноярский государственный медицинский университет им. проф. В.Ф. Войно-ЯсенецкогоРоссияProf. V.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation202506022025161513Copyright © Цхай В.Б., Гребенникова Э.К., Скуратова Ю.Н., 20252025Цхай В.Б., Гребенникова Э.К., Скуратова Ю.Н.Tskhay V.B., Grebennikova E.K., Skuratova J.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/2004

В статье проведён научный обзор литературы, посвящённый важной проблеме — рецидивированию эндометриомы яичника в послеоперационном периоде. Анализ данных производился на основании зарубежных и отечественных источников («e-Library», «Springer Nature», «Wiley Journals», «PubMed») за 2016–2023 гг. по следующим ключевым словам: «эндометриома», «факторы риска», «рецидив», «прогнозирование», «биомаркеры». В процессе анализа литературы установлена значительная взаимосвязь между бесплодием и эндометриозом яичников, но все механизмы в возникновении бесплодия при эндометриомах яичника остаются не изученными до конца. Подробно описаны неинвазивные маркеры, участвующие в патогенезе заболевания (апоптоза, ангиогенеза, адгезии), а также возможности диагностической модели неинвазивной диагностики эндометриом в послеоперационном периоде. Выделены и обобщены данные об эффективности приема медикаментозной терапии, как способа профилактики послеоперационного рецидива заболевания.

Objective: this article is a scientific review of the literature devoted to the important problem of ovarian endometrioma recurrence in the postoperative period. The data were analyzed based on foreign and domestic sources e-Library, Springer Nature, Wiley Journals, PubMed for 2016–2023 using the following keywords: «endometrioma», «risk factors», «recurrence», «prediction», «biomarkers». In the process of literature review, a significant relationship between infertility and ovarian endometriosis has been established, but all mechanisms in the occurrence of infertility in ovarian endometriomas remain incompletely understood. Noninvasive markers involved in the pathogenesis of the disease - apoptosis, angiogenesis, adhesion, as well as the possibilities of the diagnostic model of noninvasive diagnosis of endometriomas in the postoperative period are described in detail. The data on the effectiveness of drug therapy, as a way of preventing postoperative recurrence of the disease are highlighted and summarized.

эндометриозэндометриома яичникафакторы рискарецидив после операциипрогнозированиебиомаркерыendometriosisovarian endometriomarisk factorsrelapse after surgeryforecastingbiomarkersИсследование не имело спонсорской поддержки.ReferencesBergman-Larsson J, Gustafsson S, Méar L, Huvila J, Tolf A, et al. Combined expression of HOXA11 and CD10 identifies endometriosis versus normal tissue and tumors. Ann Diagn Pathol. 2022;56:151870. https://doi.org/10.1016/j.anndiagpath.2021.151870Bergman-Larsson J, Gustafsson S, Méar L, Huvila J, Tolf A, et al. Combined expression of HOXA11 and CD10 identifies endometriosis versus normal tissue and tumors. Ann Diagn Pathol. 2022;56:151870. https://doi.org/10.1016/j.anndiagpath.2021.151870Адамян Л.В., Алясова А.В., Пивазян Л.Г., Степанян А.А. Иммунологические аспекты эндометриоза: патофизиологические механизмы, диагностика, аутоиммунитет, таргетная терапия и модуляция. Проблемы репродукции. 2024;30(2):15-31. https://doi.org/10.17116/repro20243002115Adamyan LV, Alyasova AV, Pivazyan LG, Stepanian AA. Immunological aspects of endometriosis: pathophysiological mechanisms, diagnosis, autoimmunity, targeted therapy and modulation. Russian Journal of Human Reproduction. 2024;30(2):15-31. (In Russ.) https://doi.org/10.17116/repro20243002115Подзолкова Н.М., Фадеев И.Е., Масс Е.Е., Полетова Т.Н., Сумятина Л.В., Денисова Т.В. Неинвазивная диагностика и консервативная терапия эндометриоза. Гинекология. 2022;24(3):167-173. https://doi.org/10.26442/20795696.2022.3.201508Podzolkova N.M., Fadeev I.E., Mass E.E., Poletova T.N., Sumyatina L.V., Denisova T.V. Non-invasive diagnosis and non-surgical treatment of endometriosis: A review. Gynecology. 2022;24(3):167-173. (In Russ.) https://doi.org/10.26442/20795696.2022.3.201508Балан В.Е., Орлова С.А., Титченко Ю.П., Федоров А.А., Федоров А.А. Неинвазивные маркеры эндометриоза и динамика их уровня на фоне гормональной терапии. Проблемы репродукции. 2018;24(5):77-81. https://doi.org/10.17116/repro20182405177Balan V.E., Orlova S.A., Titchenko Iu.P., Fedorov A.A. Noninvasive markers of endometriosis and their dynamics during hormone therapy. Russian Journal of Human Reproduction. 2018;24(5):77-81. (In Russ.) https://doi.org/10.17116/repro20182405177Sun M, Xu P, Zou G, Wang J, Zhu L, Zhang X. Extrinsic Adenomyosis Is Associated With Postoperative Recurrence of Ovarian Endometrioma. Front Med (Lausanne). 2022;8:815628. https://doi.org/10.3389/fmed.2021.815628Sun M, Xu P, Zou G, Wang J, Zhu L, Zhang X. Extrinsic Adenomyosis Is Associated With Postoperative Recurrence of Ovarian Endometrioma. Front Med (Lausanne). 2022;8:815628. https://doi.org/10.3389/fmed.2021.815628Choi SH, Kim S, Lee SW, Won S, Shim SH, et al. Recurrence, Reoperation, Pregnancy Rates, and Risk Factors for Recurrence after Ovarian Endometrioma Surgery: Long-Term Follow-Up of 756 Women. Yonsei Med J. 2023;64(3):204-212. https://doi.org/10.3349/ymj.2022.0278Choi SH, Kim S, Lee SW, Won S, Shim SH, et al. Recurrence, Reoperation, Pregnancy Rates, and Risk Factors for Recurrence after Ovarian Endometrioma Surgery: Long-Term Follow-Up of 756 Women. Yonsei Med J. 2023;64(3):204-212. https://doi.org/10.3349/ymj.2022.0278Солопова А.Г., Ачкасов Е.Е., Москвичёва В.С., Григорьевская Ё., Ампилогова Д.М. Наружный генитальный эндометриоз: вопросы лечения и реабилитации. Акушерство, Гинекология и Репродукция. 2021;15(1):70-79. https://doi.org/10.17749/2313-7347/ob.gyn.rep.2020.148Solopova A.G., Achkasov E.E., Moskvichyova V.S., Grigorevskaya E., Ampilogova D.M. External genital endometriosis: treatment and rehabilitation. Obstetrics, Gynecology and Reproduction. 2021;15(1):70-79. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2020.148Давыдов А.И., Михалева Л.М., Таирова М.Б., Пацап О.И. Эндометриоз яичников: форма генитального эндометриоза или отдельная нозологическая единица? Вопросы гинекологии, акушерства и перинатологии. 2019;18(5):5–12. https://doi.org/10.20953/1726-1678-2019-5-5-12.Davydov A.I., Mikhaleva L.M., Tairova M.B., Patsap O.I. Ovarian endometriosis: a form of genital endometriosis or a separate nosological entity? Issues of gynecology, obstetrics and perinatology. 2019;18(5):5–12. (In Russ.) https://doi.org/10.20953/1726-1678-2019-5-5-12.Gałczyński K, Jóźwik M, Lewkowicz D, Semczuk-Sikora A, Semczuk A. Ovarian endometrioma – a possible finding in adolescent girls and young women: a mini-review. J Ovarian Res. 2019;12(1):104. https://doi.org/10.1186/s13048-019-0582-5Gałczyński K, Jóźwik M, Lewkowicz D, Semczuk-Sikora A, Semczuk A. Ovarian endometrioma – a possible finding in adolescent girls and young women: a mini-review. J Ovarian Res. 2019;12(1):104. https://doi.org/10.1186/s13048-019-0582-5Ярмолинская М.И., Русина Е.И., Хачатурян А.Р., Флорова М.С. Клиника и диагностика генитального эндометриоза. Журнал акушерства и женских болезней. 2016;65(5):4-21. https://doi.org/10.17816/JOWD6554-21Yarmolinskaya M.I., Rusina E.I., Khachaturyan A.R., Florova M.S. Clinical picture and diagnosis of genital endometriosis. Journal of obstetrics and women’s diseases. 2016;65(5):4-21. https://doi.org/10.17816/JOWD6554-21Sasaran V, Alexa Bad CM, Muresan D, Puscasiu L. Ultrasound pattern and diagnostic accuracy of primary ovarian endometrioma and its recurrence: a pictorial essay. Med Ultrason. 2020;22(2):230-235. https://doi.org/10.11152/mu-2331Sasaran V, Alexa Bad CM, Muresan D, Puscasiu L. Ultrasound pattern and diagnostic accuracy of primary ovarian endometrioma and its recurrence: a pictorial essay. Med Ultrason. 2020;22(2):230-235. https://doi.org/10.11152/mu-2331Huang G, Fan X, Zhu P. Analysis of recurrence factors associated with conservative surgery for ovarian-type endometriosis. Ann Transl Med. 2022;10(5):255. https://doi.org/10.21037/atm-22-189Huang G, Fan X, Zhu P. Analysis of recurrence factors associated with conservative surgery for ovarian-type endometriosis. Ann Transl Med. 2022;10(5):255. https://doi.org/10.21037/atm-22-189Becker CM, Bokor A, Heikinheimo O, Horne A, Jansen F, et al. ESHRE guideline: endometriosis. Hum Reprod Open. 2022;2022(2):hoac009. https://doi.org/10.1093/hropen/hoac009Becker CM, Bokor A, Heikinheimo O, Horne A, Jansen F, et al. ESHRE guideline: endometriosis. Hum Reprod Open. 2022;2022(2):hoac009. https://doi.org/10.1093/hropen/hoac009Leyland N, Casper R, Laberge P, Singh SS; SOGC. Endometriosis: diagnosis and management. J Obstet Gynaecol Can. 2010;32(7 Suppl 2):S1-32. PMID: 21545757Leyland N, Casper R, Laberge P, Singh SS; SOGC. Endometriosis: diagnosis and management. J Obstet Gynaecol Can. 2010;32(7 Suppl 2):S1-32. PMID: 21545757Carmona F, Martínez-Zamora MA, Rabanal A, Martínez-Román S, Balasch J. Ovarian cystectomy versus laser vaporization in the treatment of ovarian endometriomas: a randomized clinical trial with a five-year follow-up. Fertil Steril. 2011;96(1):251-254. https://doi.org/10.1016/j.fertnstert.2011.04.068Carmona F, Martínez-Zamora MA, Rabanal A, MartínezRomán S, Balasch J. Ovarian cystectomy versus laser vaporization in the treatment of ovarian endometriomas: a randomized clinical trial with a five-year follow-up. Fertil Steril. 2011;96(1):251-254. https://doi.org/10.1016/j.fertnstert.2011.04.068Muzii L, Achilli C, Lecce F, Bianchi A, Franceschetti S, et al. Second surgery for recurrent endometriomas is more harmful to healthy ovarian tissue and ovarian reserve than first surgery. Fertil Steril. 2015;103(3):738-743. https://doi.org/10.1016/j.fertnstert.2014.12.101Muzii L, Achilli C, Lecce F, Bianchi A, Franceschetti S, et al. Second surgery for recurrent endometriomas is more harmful to healthy ovarian tissue and ovarian reserve than first surgery. Fertil Steril. 2015;103(3):738-743. https://doi.org/10.1016/j.fertnstert.2014.12.101Yang X, Bao M, Hang T, Sun W, Liu Y, et al. Status and related factors of postoperative recurrence of ovarian endometriosis: a cross-sectional study of 874 cases. Arch Gynecol Obstet. 2023;307(5):1495-1501. https://doi.org/10.1007/s00404-023-06932-xYang X, Bao M, Hang T, Sun W, Liu Y, et al. Status and related factors of postoperative recurrence of ovarian endometriosis: a cross-sectional study of 874 cases. Arch Gynecol Obstet. 2023;307(5):1495-1501. https://doi.org/10.1007/s00404-023-06932-xТихомиров А.Л. Эндометриоз: качество, прогноз жизни и профилактика. Акушерство и гинекология: Новости. Мнения. Обучения. 2020;8(3):132-136. https://doi.org/10.24411/2303-9698-2020-13022Tikhomirov A.L. Endometriosis: quality of life, prognosis and prevention. Obstetrics and gynecology:news, opinions, training. 2020;8(3):132-136 (In Russ.) https://doi.org/10.24411/2303-9698-2020-13022Оразов М.Р., Радзинский В.Е., Хамошина М.Б., Кавтеладзе Е.В., Пухальская И.Ф., и др. Эффективность лечения бесплодия, обусловленного рецидивирующим наружным генитальным эндометриозом. Гинекология. 2019;21(1):38-43. https://doi.org/10.26442/20795696.2019.1.190230Orazov M.R., Radzinskiy V.E., Khamoshina M.B., Kavteladze E.V., Pukhalskaya I.F., et al. Treatment efficacy of infertility due to recurrent external genital endometriosis. Gynecology. 2019;21(1):38-43. (In Russ.) https://doi.org/10.26442/20795696.2019.1.190230Li XY, Chao XP, Leng JH, Zhang W, Zhang JJ, et al. Risk factors for postoperative recurrence of ovarian endometriosis: longterm follow-up of 358 women. J Ovarian Res. 2019;12(1):79. https://doi.org/10.1186/s13048-019-0552-yLi XY, Chao XP, Leng JH, Zhang W, Zhang JJ, et al. Risk factors for postoperative recurrence of ovarian endometriosis: longterm follow-up of 358 women. J Ovarian Res. 2019;12(1):79. https://doi.org/10.1186/s13048-019-0552-yMuzii L, Galati G, Mattei G, Chinè A, Perniola G, et al. Expectant, Medical, and Surgical Management of Ovarian Endometriomas. J Clin Med. 2023;12(5):1858. https://doi.org/10.3390/jcm12051858Muzii L, Galati G, Mattei G, Chinè A, Perniola G, et al. Expectant, Medical, and Surgical Management of Ovarian Endometriomas. J Clin Med. 2023;12(5):1858. https://doi.org/10.3390/jcm12051858Shaltout MF, Elsheikhah A, Maged AM, Elsherbini MM, Zaki SS, et al. A randomized controlled trial of a new technique for laparoscopic management of ovarian endometriosis preventing recurrence and keeping ovarian reserve. J Ovarian Res. 2019;12(1):66. https://doi.org/10.1186/s13048-019-0542-0Shaltout MF, Elsheikhah A, Maged AM, Elsherbini MM, Zaki SS, et al. A randomized controlled trial of a new technique for laparoscopic management of ovarian endometriosis preventing recurrence and keeping ovarian reserve. J Ovarian Res. 2019;12(1):66. https://doi.org/10.1186/s13048-019-0542-0Tan Z, Gong X, Li Y, Hung SW, Huang J, et al. Impacts of endometrioma on ovarian aging from basic science to clinical management. Front Endocrinol (Lausanne). 2023;13:1073261. https://doi.org/10.3389/fendo.2022.1073261Tan Z, Gong X, Li Y, Hung SW, Huang J, et al. Impacts of endometrioma on ovarian aging from basic science to clinical management. Front Endocrinol (Lausanne). 2023;13:1073261. https://doi.org/10.3389/fendo.2022.1073261Бахтияров К.Р., Семерюк Т.А., Чурганова А.А. Сохранение овариального резерва у больных с эндометриозом. Здоровье и образование в XXI веке. 2018;20(5):9-14.Bakhtiyarov K.R., Semeryuk T.A., Churganova A.A. Preservation of the ovarian reserve in patients with endometriosis. Zdorov’e i obrazovanie v XXI veke. 2018;20(5):9-14 (In Russ.). eLIBRARY ID: 34964673 EDN: XOCTCXBonavina G, Taylor HS. Endometriosis-associated infertility: From pathophysiology to tailored treatment. Front Endocrinol (Lausanne). 2022;13:1020827. https://doi.org/10.3389/fendo.2022.1020827Bonavina G, Taylor HS. Endometriosis-associated infertility: From pathophysiology to tailored treatment. Front Endocrinol (Lausanne). 2022;13:1020827. https://doi.org/10.3389/fendo.2022.1020827Kasapoglu I, Ata B, Uyaniklar O, Seyhan A, Orhan A, et al. Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study. Fertil Steril. 2018;110(1):122-127. https://doi.org/10.1016/j.fertnstert.2018.03.015Kasapoglu I, Ata B, Uyaniklar O, Seyhan A, Orhan A, et al. Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study. Fertil Steril. 2018;110(1):122-127. https://doi.org/10.1016/j.fertnstert.2018.03.015Filip L, Duică F, Prădatu A, Crețoiu D, Suciu N, et al. Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches. Medicina (Kaunas). 2020;56(9):460. https://doi.org/10.3390/medicina56090460Filip L, Duică F, Prădatu A, Crețoiu D, Suciu N, et al. Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches. Medicina (Kaunas). 2020;56(9):460. https://doi.org/10.3390/medicina56090460Оразов М.Р., Хамошина М.Б., Абитова М.З., Михалева Л.М., Волкова С.В., и др. Бесплодие, ассоциированное с эндометриозом яичников: современный взгляд на проблему. Гинекология. 2020;22(5):44-49. https://doi.org/10.26442/20795696.2020.5.200405Orazov M.R., Khamoshina M.B., Abitova M.Z., Mikhaleva L.M., Volkova S.V., et al. Ovarian endometriosis associated infertility: a modern view to the problem. Gynecology. 2020;22(5):44-49. (In Russ.) https://doi.org/10.26442/20795696.2020.5.200405Sengoku K, Miyamoto T, Horikawa M, Katayama H, Nishiwaki K, et al. Clinicopathologic risk factors for recurrence of ovarian endometrioma following laparoscopic cystectomy. Acta Obstet Gynecol Scand. 2013;92(3):278-284. https://doi.org/10.1111/aogs.12051Sengoku K, Miyamoto T, Horikawa M, Katayama H, Nishiwaki K, et al. Clinicopathologic risk factors for recurrence of ovarian endometrioma following laparoscopic cystectomy. Acta Obstet Gynecol Scand. 2013;92(3):278-284. https://doi.org/10.1111/aogs.12051Yang F, Liu B, Xu L, Liu H. Age at surgery and recurrence of ovarian endometrioma after conservative surgery: a meta-analysis including 3125 patients. Arch Gynecol Obstet. 2020;302(1):23-30. https://doi.org/10.1007/s00404-020-05586-3Yang F, Liu B, Xu L, Liu H. Age at surgery and recurrence of ovarian endometrioma after conservative surgery: a meta-analysis including 3125 patients. Arch Gynecol Obstet. 2020;302(1):23-30. https://doi.org/10.1007/s00404-020-05586-3Качалина Т.С., Богатова М.Е., Кузнецов С.С., Лазукин В.Ф. Факторы риска рецидива эндометриоидных кист яичников после хирургического лечения: ретроспективное когортное исследование. Сеченовский вестник. 2020;11(4):60–71. https://doi.org/10.47093/2218-7332.2020.11.4.60-71Kachalina T.S., Bogatova M.E., Kuznetsov S.S., Lazukin V.F. Risk factors for recurrence of ovarian endometriomas after surgical treatment: retrospective cohort study. Sechenov Medical Journal. 2020;11(4):60–71. (In Russ.) https://doi.org/10.47093/2218-7332.2020.11.4.60-71Борисова АВ, Козаченко АВ, Франкевич ВЕ, Чаговец ВВ, Кононихин АС, и др. Факторы риска развития рецидива наружного генитального эндометриоза после оперативного лечения: проспективное когортное исследование. Медицинский Совет. 2018;(7):32-38. https://doi.org/10.21518/2079-701X-2018-7-32-38Borisova AV, Kozachenko AV, Frankevich VE, Chagovets VV, Kononokhin AS, et al. Risk factors for recurrence of external genital endometriosis after surgical treatment: prospective cohortant study. Meditsinskiy sovet = Medical Council. 2018;(7):32-38. (In Russ.) https://doi.org/10.21518/2079-701X-2018-7-32-38Ding S, Lin Q, Zhu T, Li T, Zhu L, et al. Is there a correlation between inflammatory markers and coagulation parameters in women with advanced ovarian endometriosis? BMC Womens Health. 2019;19(1):169. https://doi.org/10.1186/s12905-019-0860-9Ding S, Lin Q, Zhu T, Li T, Zhu L, et al. Is there a correlation between inflammatory markers and coagulation parameters in women with advanced ovarian endometriosis? BMC Womens Health. 2019;19(1):169. https://doi.org/10.1186/s12905-019-0860-9Ling X, Wang T. Diagnostic and prognostic value of coagulation-related factors in endometriosis. Am J Transl Res. 2022;14(11):7924-7931. PMID: 36505289; PMCID: PMC9730110.Ling X, Wang T. Diagnostic and prognostic value of coagulation-related factors in endometriosis. Am J Transl Res. 2022;14(11):7924-7931. PMID: 36505289; PMCID: PMC9730110.Бегович Ё., Солопова А.Г., Идрисова Л.Э., Хлопкова С.В. Наружный генитальный эндометриоз: качество жизни и реабилитационные технологии. Врач. 2021;32(8):11-17. https://doi.org/10.29296/25877305-2021-08-02Begovich E., Solopova A.G., Idrisova L.EH., Khlopkova S. Quality of life and rehabilitation technologies in patients with external genital endometriosis. Vrach. 2021;32(8):11-17. (In Russ.). https://doi.org/10.29296/25877305-2021-08-02Luo J, Song Z, Zhang T, Chu K, Li J, et al. Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis. J Zhejiang Univ Sci B. 2022;23(2):158-163. https://doi.org/10.1631/jzus.B2100502Luo J, Song Z, Zhang T, Chu K, Li J, et al. Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis. J Zhejiang Univ Sci B. 2022;23(2):158-163. https://doi.org/10.1631/jzus.B2100502Адамян Л.В., Азнаурова Я.Б. Биомаркеры эндометриоза – современные тенденции. 2018;24(1):57-62. https://doi.org/10.17116/repro201824157-62Adamyan LV, Aznaurova YaB. Biomarkers of endometriosis — current trends. Problemy reprodukcii. 2018;24(1):57-62. (In Russ.). https://doi.org/10.17116/repro201824157-62Межлумова Н.А., Бобров М.Ю., Адамян Л.В. Биомаркеры эндометриоза: проблемы и возможности ранней диагностики рецидивов заболевания (обзор литературы). Проблемы репродукции. 2018;24(6):139-148. https://doi.org/10.17116/repro201824061139Mezhlumova NA, Bobrov MYu, Adamyan LV. Biomarkers of endometriosis: problems and possibilities of early detection of disease recurrence (a review). Russian Journal of Human Reproduction. 2018;24(6):139-148. (In Russ.) https://doi.org/10.17116/repro201824061139Chmaj-Wierzchowska K, Kampioni M, Wilczak M, Sajdak S, Opala T. Novel markers in the diagnostics of endometriomas: Urocortin, ghrelin, and leptin or leukocytes, fibrinogen, and CA-125? Taiwan J Obstet Gynecol. 2015;54(2):126-130. https://doi.org/10.1016/j.tjog.2014.08.004Chmaj-Wierzchowska K, Kampioni M, Wilczak M, Sajdak S, Opala T. Novel markers in the diagnostics of endometriomas: Urocortin, ghrelin, and leptin or leukocytes, fibrinogen, and CA-125? Taiwan J Obstet Gynecol. 2015;54(2):126-130. https://doi.org/10.1016/j.tjog.2014.08.004Kimber-Trojnar Ż, Pilszyk A, Niebrzydowska M, Pilszyk Z, Ruszała M, Leszczyńska-Gorzelak B. The Potential of Non-Invasive Biomarkers for Early Diagnosis of Asymptomatic Patients with Endometriosis. J Clin Med. 2021;10(13):2762. https://doi.org/10.3390/jcm10132762Kimber-Trojnar Ż, Pilszyk A, Niebrzydowska M, Pilszyk Z, Ruszała M, Leszczyńska-Gorzelak B. The Potential of NonInvasive Biomarkers for Early Diagnosis of Asymptomatic Patients with Endometriosis. J Clin Med. 2021;10(13):2762. https://doi.org/10.3390/jcm10132762Абитова М.З., Оразов М.Р., Хамошина М.Б., Волкова С.В., Арютин Д.Г., Демина О.А. Эндометриоз яичников – прогнозирование рецидивов: современная парадигма. Акушерство и гинекология: новости, мнения, обучение. 2020;8(3):115-120. https://doi.org/10.24411/2303-9698-2020-13019Abitova M.Z., Orazov M.R., Khamoshina M.B., Volkova S.V., Aryutin D.G., Demina О.А. Ovarian endometriosis-relapse prediction: a modern paradigm. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie [Obstetrics and Gynecology: News, Opinions, Training]. 2020;8(3):115-120. (in Russ.) https://doi.org/10.24411/2303-9698-2020-13019Brătilă E, Brătilă CP, Comandaşu DE, Bauşic V, Vlădescu CT, et al. The assessment of immunohistochemical profile of endometriosis implants, a practical method to appreciate the aggressiveness and recurrence risk of endometriosis. Rom J Morphol Embryol. 2015;56(4):1301-1307. PMID: 26743275.Brătilă E, Brătilă CP, Comandaşu DE, Bauşic V, Vlădescu CT, et al. The assessment of immunohistochemical profile of endometriosis implants, a practical method to appreciate the aggressiveness and recurrence risk of endometriosis. Rom J Morphol Embryol. 2015;56(4):1301-1307. PMID: 26743275.Zhang J, Wang H, Meng Q, Chen J, Wang J, Huang S. Expression of MTA1 in endometriosis and its relationship to the recurrence. Medicine (Baltimore). 2018;97(35):e12115. https://doi.org/10.1097/MD.0000000000012115Zhang J, Wang H, Meng Q, Chen J, Wang J, Huang S. Expression of MTA1 in endometriosis and its relationship to the recurrence. Medicine (Baltimore). 2018;97(35):e12115. https://doi.org/10.1097/MD.0000000000012115Guo SW. Recurrence of endometriosis and its control. Hum Reprod Update. 2009;15(4):441-461. https://doi.org/10.1093/humupd/dmp007Guo SW. Recurrence of endometriosis and its control. Hum Reprod Update. 2009;15(4):441-461. https://doi.org/10.1093/humupd/dmp007Sansone AM, Hisrich BV, Young RB, Abel WF, Bowens Z, et al. Evaluation of BCL6 and SIRT1 as Non-Invasive Diagnostic Markers of Endometriosis. Curr Issues Mol Biol. 2021;43(3):1350-1360. https://doi.org/10.3390/cimb43030096Sansone AM, Hisrich BV, Young RB, Abel WF, Bowens Z, et al. Evaluation of BCL6 and SIRT1 as Non-Invasive Diagnostic Markers of Endometriosis. Curr Issues Mol Biol. 2021;43(3):1350-1360. https://doi.org/10.3390/cimb43030096Пшеничнюк Е.Ю., Асатурова А.В., Адамян Л.В., Зайцев Н.В.. Иммуногистохимические особенности эутопического и эктопического эндометрия у пациенток с рецидивирующим течением эндометриоидных кист яичников. Акушерство и гинекология. 2018;(3):84-95. https://doi.org/10.18565/aig.2018.3.84-95Pshenichnyuk E.Yu., Asaturova A.V., Adamyan L.V., Zaitsev N.V. Immunohistochemical features of eutopic and ectopic endometrium in patients with recurrent ovarian endometrioid cysts. Obstetrics and Gynegology. 2018;(3):84-95 (In Russ.). https://doi.org/10.18565/aig.2018.3.84-95Selcuk S, Cam C, Koc N, Kucukbas M, Ozkaya E, et al. Evaluation of risk factors for the recurrence of ovarian endometriomas. Eur J Obstet Gynecol Reprod Biol. 2016;203:56-60. https://doi.org/10.1016/j.ejogrb.2016.05.008Selcuk S, Cam C, Koc N, Kucukbas M, Ozkaya E, et al. Evaluation of risk factors for the recurrence of ovarian endometriomas. Eur J Obstet Gynecol Reprod Biol. 2016;203:56-60. https://doi.org/10.1016/j.ejogrb.2016.05.008Xu X, Chen Y, Yu Q, Wang J, Xu P, et al. The presence of living endometrial cells in ovarian endometriotic cyst fluid may contribute to the recurrence of endometriosis after surgical excision of endometriomas. J Ovarian Res. 2022;15(1):89. https://doi.org/10.1186/s13048-022-01018-9Xu X, Chen Y, Yu Q, Wang J, Xu P, et al. The presence of living endometrial cells in ovarian endometriotic cyst fluid may contribute to the recurrence of endometriosis after surgical excision of endometriomas. J Ovarian Res. 2022;15(1):89. https://doi.org/10.1186/s13048-022-01018-9Артымук Н.В., Зотова О.А., Ваулина Е.Н. Эндометриомы: эффективность комбинированного лечения. Гинекология. 2021;23(6):536-541. https://doi.org/10.26442/20795696.2021.6.201173Artymuk N.V., Zotova O.A., Vaulina E.N. Endometriomas: the effectiveness of combination treatment. Gynecology. 2021;23(6):536-541. https://doi.org/10.26442/20795696.2021.6.201173Wacharachawana S, Phaliwong P, Prommas S, Smanchat B, Bhamarapravatana K, Suwannarurk K. Recurrence Rate and Risk Factors for the Recurrence of Ovarian Endometriosis after Laparoscopic Ovarian Cystectomy. Biomed Res Int. 2021;2021:6679641. https://doi.org/10.1155/2021/6679641Wacharachawana S, Phaliwong P, Prommas S, Smanchat B, Bhamarapravatana K, Suwannarurk K. Recurrence Rate and Risk Factors for the Recurrence of Ovarian Endometriosis after Laparoscopic Ovarian Cystectomy. Biomed Res Int. 2021;2021:6679641. https://doi.org/10.1155/2021/6679641Макаренко Т.А., Галкина Д.Е., Борисова Е.А. Стратегии консервативного лечения эндометриоидных кист яичников. Гинекология. 2023;25(1):4-10. https://doi.org/10.26442/20795696.2023.1.201803Makarenko T.A., Galkina D.E., Borisova E.A. Conservative treatment strategies for endometrioid ovarian cysts: A review. Gynecology. 2023;25(1):4-10. https://doi.org/10.26442/20795696.2023.1.201803Wattanayingcharoenchai R, Rattanasiri S, Charakorn C, Attia J, Thakkinstian A. Postoperative hormonal treatment for prevention of endometrioma recurrence after ovarian cystectomy: a systematic review and network meta-analysis. BJOG. 2021;128(1):25-35. https://doi.org/10.1111/1471-0528.16366Wattanayingcharoenchai R, Rattanasiri S, Charakorn C, Attia J, Thakkinstian A. Postoperative hormonal treatment for prevention of endometrioma recurrence after ovarian cystectomy: a systematic review and network meta-analysis. BJOG. 2021;128(1):25-35. https://doi.org/10.1111/1471-0528.16366Эндометриоз. Клинические рекомендации. М.: Министерство здравоохранения Российской Федерации. 2020.Endometriosis. Clinical guidelines. Moscow: Ministry of Health of the Russian Federation. 2020. (In Russ.).Беженарь В.Ф., Ярмолинская М.И., Байлюк Е.Н., Цыпурдеева А.А., Цицкарава Д.З., и др. Сравнение эффективности различных схем гормономодулирующей терапии после хирургического лечения наружного генитального эндометриоза. Проблемы репродукции. 2015;21(4):89-98. https://doi.org/10.17116/repro201521489-98Bezhenar’ VF, Iarmolinskaia MI, Baĭliuk EN, Tsypurdeeva A.A., Tsitskarava D.Z., et al. The comparison of the efficacy of different regimens of postoperative hormonal therapy in infertile women with endometriosis. Russian Journal of Human Reproduction. 2015;21(4):89-98. (In Russ.) https://doi.org/10.17116/repro201521489-98Чернуха Г.Е., Думановская М.Р., Ильина Л.М. Овариальный эндометриоз и проблема сохранения фертильности. Гинекология. 2021;23(2):110-116. https://doi.org/10.26442/20795696.2021.2.200822Chernukha G.E., Dumanovskaya M.R., Ilina L.M. Ovarian endometriosis and fertility preservation problem. Gynecology. 2021;23(2):110-116. https://doi.org/10.26442/20795696.2021.2.200822Намазова М.Р., Орлова Е.С., Артемова О.И. Сравнение патогенетических аспектов развития гинекологической патологии (обзор литературы). Сибирское медицинское обозрение. 2023;(4):5-14. eLIBRARY ID: 54671137 EDN: ULHGGKNamazova M.R., Orlova E.S., Artemova O.I. Pathogenetic aspects of development of adenomyosis and endometriosis (a review). Siberian Medical Review. 2023;(4):5-14. (In Russ.). eLIBRARY ID: 54671137 EDN: ULHGGKGu Z, Li X, Shi J, Wu Y, Zhang J, et al. The Development of Predictive Nomogram of Recurrence for Patients With Endometrioma After Cystectomy Who Were Younger Than 45 Years Old and Received Postoperative Therapy. Front Med (Lausanne). 2022;9:872481. https://doi.org/10.3389/fmed.2022.872481Gu Z, Li X, Shi J, Wu Y, Zhang J, et al. The Development of Predictive Nomogram of Recurrence for Patients With Endometrioma After Cystectomy Who Were Younger Than 45 Years Old and Received Postoperative Therapy. Front Med (Lausanne). 2022;9:872481. https://doi.org/10.3389/fmed.2022.872481

The authors declare that there are no conflicts of interest present.