mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2024-15-3-12-17mvjr-1923Research ArticleАКУШЕРСТВО И ГИНЕКОЛОГИЯOBSTETRICS AND GYNECOLOGYМолекулярно-биологические маркеры эндометриозаMolecular biological markers of endometriosishttps://orcid.org/0000-0002-4673-7003БурцевД. В.BurtsevD. V.

Бурцев Дмитрий Владимирович, д.м.н., доцент, заведующий кафедрой персонализированной и трансляционной медицины;

главный врач

Ростов-на-Дону

Dmitry V. Burtsev, Dr. Sci. (Med.), Associated Professor, Head of the Department of Personalized and Translational Medicine;

Chief Physician

Rostov-on-Don

dr-burtsev@mail.ruhttps://orcid.org/0000-0002-5399-6636ДимитриадиТ. А.DimitriadiT. A.

Димитриади Татьяна Александровна, д.м.н., доцент кафедры персонализированной и трансляционной медицины;

руководитель областного центра патологии шейки матки, врач акушер-гинеколог

Ростов-на-Дону

Tatyana A. Dimitriadi, Dr. Sci. (Med.), Associated Professor of the Department of Personalized and Translational Medicine;

Head of the Regional Center for Cervical Pathology, obstetrician-gynecologist

Rostov-on-Don

tdimitriadi@yandex.ruhttps://orcid.org/0009-0000-8773-8777СядневаН. П.SyadnevaN. P.

Сяднева Наталья Павловна, врач акушер-гинеколог

Ростов-на-Дону

Natalya P. Syadneva, obstetrician-gynecologist

Rostov-on-Don

nataguseva92@gmail.comРостовский государственный медицинский университет; Областной Консультативно-диагностический ЦентрРоссияRostov State Medical University; Rostov Region Regional Consultative and Diagnostic CenterRussian FederationОбластной Консультативно-диагностический ЦентрРоссияRostov Region Regional Consultative and Diagnostic CenterRussian Federation2024080720241531217Copyright © Бурцев Д.В., Димитриади Т.А., Сяднева Н.П., 20242024Бурцев Д.В., Димитриади Т.А., Сяднева Н.П.Burtsev D.V., Dimitriadi T.A., Syadneva N.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1923

Эндометриоз — хроническое гормонозависимое заболевание, для которого типично возникновение доброкачественных разрастаний ткани, по функциональным свойствам и структуре подобной эндометрию. Это заболевание поражает до 10% женщин репродуктивного возраста, значительно снижая работоспособность, фертильность и качество жизни. Диагностика эндометриоза основана на клинической картине, ультразвуковом исследовании (УЗИ) и магнитно-резонансной томографии (МРТ), однако постановка диагноза часто затрудняется отсутствием объективных критериев. Несмотря на практическую необходимость, в настоящее время не существует малоинвазивных высокочувствительных методов диагностики эндометриоза. В статье освещён обзор современных данных литературы о результатах поиска молекулярно-биологических маркеров эндометриоза в эктопических очагах и эутопическом эндометрии, особенностях их экспрессии и возможности применения в медицинской практике. Цитируемые в исследовании работы были отобраны с использованием ключевых слов «эндометриоз», «микроРНК», «молекулярные маркеры эндометриоза», «эутопический эндометрий» в поисковых системах PubMed, MedLine. Публикации должны были удовлетворять следующим критериям: публикация в последние 5–7 лет; языки публикации — русский, английский; доступ к полному тексту публикации. Литература, не индексированная в медицинских базах данных, не подлежала исследованию. Также из анализа исключались онкологические исследования, исследования, касающиеся экстрагенитальных форм эндометриоза, статьи о методах инвазивной диагностики и хирургического лечения. Из около 500 публикаций были выбраны 29 статей, соответствующих критериям отбора и максимально отражающих современное состояние вопроса неинвазивной и малоинвазивной диагностики эндометриоза.

Endometriosis is a chronic hormone-dependent disease, which is typically characterized by the occurrence of benign growths of tissue, similar in functional properties and structure to the endometrium. This disease affects up to 10% of women of reproductive age, significantly reducing performance, fertility and quality of life. Diagnosis of endometriosis is based on clinical presentation, ultrasound (US) and magnetic resonance imaging (MRI), but diagnosis is often hampered by the lack of objective criteria. Despite the practical necessity, there are currently no minimally invasive, highly sensitive methods for diagnosing endometriosis. The article covers a review of modern literature data on the results of the search for molecular biological markers of endometriosis in ectopic foci and eutopic endometrium, the characteristics of their expression and the possibility of application in medical practice. Works cited in the study were selected using the keywords “endometriosis”, “microRNA”, “molecular markers of endometriosis”, “eutopic endometrium” in the search engines PubMed, MedLine. Publications had to meet the following criteria: published in the last 5–7 years; publication language – Russian, English; access to the full text of the publication; Literature not indexed in medical databases was not examined. Also excluded from the analysis were oncological studies, studies concerning extragenital forms of endometriosis, articles on methods of invasive diagnostics and surgical treatment. As a result, 29 articles were selected that met the selection criteria and maximally reflected the current state of the issue of non-invasive and minimally invasive diagnosis of endometriosis.

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The authors declare that there are no conflicts of interest present.