mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2024-15-3-26-32mvjr-1919Research Article3.1.17 ПСИХИАТРИЯ И НАРКОЛОГИЯPSYCHIATRY AND NARCOLOGYВлияние наследственной отягощённости расстройствами шизофренического спектра на клиническую картину шизофренииThe influence of family history of schizophrenic spectrum disorders on the clinical presentation of schizophreniahttps://orcid.org/0000-0001-9944-141XГашкаримовВ. Р.GashkarimovV. R.

Гашкаримов Вадим Римович, врач-психиатр

Уфа

Vadim R. Gashkarimov, psychiatrist

Ufa

gashkarimov@yandex.ruhttps://orcid.org/0000-0001-6679-4454СултановаР. И.SultanovaR. I.

Султанова Рената Ильдаровна, врач-психиатр

Москва

Renata I. Sultanova, psychiatrist

Moscow

renatasu@mail.ruhttps://orcid.org/0000-0002-9994-8656ЕфремовИ. С.EfremovI. S.

Ефремов Илья Сергеевич, к.м.н., заместитель директора центра молекулярной медицины

Уфа;

научный сотрудник

Санкт-Петербург

Ilya S. Efremov, Cand. Sci. (Med.), Deputy Director of the Center for Molecular medicine;

Researcher

Ufa;

Saint-Petersburg

efremovilya@gmail.comhttps://orcid.org/0000-0003-4885-7495СабанаеваИ. Э.SabanaevaI. E.

Сабанаева Илина Эдуардовна, студентка 5-го курса

Уфа

Ilina E. Sabanaeva, 5th year student

Ufa

ilinasabanaeva@mail.ruhttps://orcid.org/0009-0005-8528-8457ИсхаковА. А.IskhakovA. A.

Исхаков Анатолий Айратович, ординатор 2-го года кафедры психиатрии, наркологии и психотерапии

Уфа

Anatoliy A. Iskhakov, clinical resident-psychiatrist, Department of Psychiatry Narcology and Psychotherapy

Ufa

hostyfellow@gmail.comhttps://orcid.org/0000-0002-7519-436XБакировЛ. Р.BakirovL. R.

Бакиров Линар Рифкатович, врач-психиатр;

доцент кафедры психиатрии, наркологии и психотерапии

Уфа

Linar R. Bakirov, psychiatrist;

assistant professor, Department of Psychiatry, Narcology and Psychotherapy

Ufa

Blr.ufa@yandex.ruhttps://orcid.org/0000-0001-7148-4485АсадуллинА. Р.AsadullinA. R.

Асадуллин Азат Раилевич, д.м.н., профессор кафедры психиатрии, наркологии и психотерапии;

директор центра молекулярной медицины;

ведущий научный сотрудник института персонализированной психиатрии и неврологии;

профессор кафедры психиатрии, наркологии, психотерапии и клинической психологии

Уфа;

Санкт-Петербург;

Саратов

Azat R. Asadullin, Dr. Sci. (Med.), Professor, Department of Psychiatry, Narcology and Psychotherapy;

Director of the Center for Molecular medicine;

Leading Researcher;

Professor, Department of Psychiatry, Narcology, Psychotherapy and clinical psychology

Ufa;

Saint-Petersburg;

Saratov

droar@yandex.ruРеспубликанская клиническая психиатрическая больницаРоссияRepublican Clinical Psychiatric HospitalRussian FederationНаучно-практический психоневрологический центр имени З.П. СоловьеваРоссияMoscow Research and Clinical Center for NeuropsychiatryRussian FederationУфимский университет науки и технологий; Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. БехтереваРоссияUfa University of Science and Technology; V.M. Bekhterev National Medical Research Centre for Psychiatry and NeurologyRussian FederationБашкирский Государственный Медицинский УниверситетРоссияBashkir State Medical UniversityRussian FederationРеспубликанский клинический психотерапевтический центр; Башкирский Государственный Медицинский УниверситетРоссияRepublican Clinical Psychotherapeutic Center; Bashkir State Medical UniversityRussian FederationБашкирский Государственный Медицинский Университет; Уфимский университет науки и технологий; Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева; Саратовский государственный медицинский университет им. В. И. РазумовскогоРоссияBashkir State Medical University; Ufa University of Science and Technology; V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology; Saratov State Medical University named after V.I. RazumovskyRussian Federation2024090720241532632Copyright © Гашкаримов В.Р., Султанова Р.И., Ефремов И.С., Сабанаева И.Э., Исхаков А.А., Бакиров Л.Р., Асадуллин А.Р., 20242024Гашкаримов В.Р., Султанова Р.И., Ефремов И.С., Сабанаева И.Э., Исхаков А.А., Бакиров Л.Р., Асадуллин А.Р.Gashkarimov V.R., Sultanova R.I., Efremov I.S., Sabanaeva I.E., Iskhakov A.A., Bakirov L.R., Asadullin A.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1919

Цель: выявление особенностей клинического дебюта шизофрении, а также клинических аспектов, связанных с наследственной отягощённостью в рамках расстройств шизофренического спектра.Материалы и методы: пациенты с подтверждённым диагнозом F20.0 «Параноидная шизофрения», отобранные по критериям включения/невключения. Сбор материала осуществлялся при помощи клинического интервьюирования, анализа медицинских карт и документации, самоопросников.Результаты: в исследовании приняли участие 264 человека. У 127 из них (48,1%) была выявлена наследственная отягощённость расстройствами шизофренического спектра в пределах двух поколений. Наши результаты показали, что наличие семейного анамнеза по заболеваниям шизофренического спектра коррелировало с более ранним возрастом дебюта шизофрении (p=0,018) и более высокими показателями по шкале депрессии Калгари (p=0,013).Выводы: полученные данные могут служить эффективным инструментом для разработки более точных стратегий диагностики у лиц с высоким риском развития шизофрении в связи с наследственной отягощённостью, а также для последующего лечения этих людей.

Objective: to identify the characteristics of the clinical debut of schizophrenia, as well as clinical aspects related to hereditary aggravation within schizophrenic spectrum disorders.Materials and methods: patients with a confirmed diagnosis of F20.0 “Paranoid schizophrenia” selected according to inclusion/non-inclusion criteria participated in the study. Material was collected through clinical interviewing, analysis of medical records and documentation, and self-questionnaires.Results: a total of 264 individuals participated in the study. Hereditary aggravation with schizophrenic spectrum disorders within two generations was detected in 127 of them (48.1%). Our results showed that having a family history of schizophrenic spectrum disorders correlated with earlier age of schizophrenia debut (p=0.018) and higher scores on the Calgary Depression Scale (p=0.013).Conclusions: the findings may serve as an effective tool for developing more accurate diagnostic strategies in individuals at high risk of developing schizophrenia due to hereditary aggravation, as well as for the subsequent treatment of these individuals.

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The authors declare that there are no conflicts of interest present.