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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2219-8075-2015-1-50-52</article-id><article-id custom-type="elpub" pub-id-type="custom">mvjr-191</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ОПТИМИЗАЦИЯ РЕЖИМОВ ХИМИОТЕРАПИИ БОЛЬНЫХ НЕХОДЖКИНСКИМИ ЛИМФОМАМИ</article-title><trans-title-group xml:lang="en"><trans-title>OPTIMIZATION OF CHEMOTHERAPY REGIMENS OF PATIENTS SUFFERING FROM NON-HODGKIN LIMPHOMA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киреева</surname><given-names>Я А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kireeva</surname><given-names>Y. A.</given-names></name></name-alternatives><email xlink:type="simple">m.d.harish@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хариш</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Harish</surname><given-names>D. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурнашева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Burnasheva</surname><given-names>E. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ростовский государственный медицинский университет, кафедра внутренних болезней № 2, отделение гематологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University, Faculty of Internal Medicine № 2, Hematology Department</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2015</year></pub-date><volume>0</volume><issue>1</issue><fpage>50</fpage><lpage>52</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Киреева Я.А., Хариш Д.И., Бурнашева Е.В., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Киреева Я.А., Хариш Д.И., Бурнашева Е.В.</copyright-holder><copyright-holder xml:lang="en">Kireeva Y.A., Harish D.I., Burnasheva E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/191">https://www.medicalherald.ru/jour/article/view/191</self-uri><abstract><sec><title>Цель</title><p>Цель: оценить эффективность различных вариантов химиотерапии у больных НХЛ.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы: проведен анализ терапии 64 больных (38 мужчин и 26 женщин) В-клеточными НХЛ в возрасте от 21 до 83 лет. Оценку эффективности лечения проводили после 3-го цикла терапии и после индукционного курса лечения, а также после завершения всей программы лечения.</p></sec><sec><title>Результаты</title><p>Результаты: общая эффективность лечения составила 80% (20 больных) (полные ремиссии получены у 52% (13 больных), частичные - у 28% (7 больных)). У 2-х больных (8%) достигнута стабилизация, у 3-х (12%) выявлено прогрессирование заболевания. В структуре осложнений преобладали гематологическая токсичность 3-4 ст. (56% больных), инфекционные осложнения (48% больных), геморрагический синдром (13% пациентов).</p></sec><sec><title>Выводы</title><p>Выводы: современная ПХТ, проводимая в зависимости от прогностической группы риска, позволяет добиться высоких показателей выживаемости у подавляющего большинства больных НХЛ.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose: to evaluate the eff ectiveness of diff erent chemotherapy variants of NHL patients.</p></sec><sec><title>Materials and methods</title><p>Materials and methods: the therapy of 64 B-cell NHL patients aged 21-83 (38 males and 28 females) has been analysed. Th e eff ectiveness of the treatment was evaluated aft er the third cycle of therapy and inductional course of treatment as well as aft er the completion of the entire treatment program.</p></sec><sec><title>Results</title><p>Results: general eff ectiveness of the treatment made 80% (20 patients), full remission made 52% (15 patients), partial remission made 28% (7 patients), stabilization was achieved in 2 cases (2 patients) (8%), in three cases (3 patients) there was progressiveness of the disease. In the structure of aft er-eff ects the prevailing ones were: hematologic toxicity III-IVst. (56% of the patients), infection (48% of the patients), hemorrhagic syndrome (13% of the patients).</p></sec><sec><title>Summary</title><p>Summary: contemporary PCT’s conducted according to prognostic risk groups, allows to achieve high survival rates for the vast majority of patients with NHL.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>неходжкинские лимфомы</kwd><kwd>эффективность</kwd><kwd>схемы полихимиотерапии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>non-Hodgkin’s lymphoma</kwd><kwd>eff ectiveness</kwd><kwd>chemotherapy scheme (diagram)</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kate R. S., James O. A., // Th e Non-Hodgkin lymphoma, 2012-09-01, Volume 380, Issue 9844, Pages 848-857. - URL: https://www.clinicalkey.com/#author2 Non-Hodgkin lymphoma (дата обращения 10.05.2013).</mixed-citation><mixed-citation xml:lang="en">Kate R. S., James O. 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