mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2024-15-1-82-93mvjr-1892Research ArticleАКУШЕРСТВО И ГИНЕКОЛОГИЯOBSTETRICS AND GYNECOLOGY«Белые пятна» в диагностическом поиске причин невынашивания беременности“White spots” in the diagnostic search for the causes of recurrent miscarriagehttps://orcid.org/0000-0003-2602-1486ЛебеденкоЕ. Ю.LebedenkoE. Yu.

Лебеденко Елизавета Юрьевна, д.м.н., доцент, заведующая кафедрой акушерства и гинекологии №3

Ростов-на-Дону

Elizaveta Yu. Lebedenko, Dr. Sc. (Med.), associate Professor, Head of the Department of Obstetrics and Gynecology No. 3

Rostov-on-Don

lebedenko08@mail.ruhttps://orcid.org/0000-0002-8282-2248МихельсонАр. А.MikhelsonAr. A.

Михельсон Артур Александрович, к.м.н., доцент кафедры акушерства и гинекологии №3

Ростов-на-Дону

Artur A. Mikhelson, C. Sc. (Med.), associate professor of the Department of Obstetrics and Gynecology No. 3

Rostov-on-Don

artur.mikhelson@gmail.comhttps://orcid.org/0000-0001-5053-5941МихельсонА. А.MikhelsonA. A.

Михельсон Александр Александрович, к.м.н., доцент кафедры акушерства и гинекологии №3

Ростов-на-Дону

Aleksandr A. Mikhelson, C. Sc. (Med.), associate professor of the Department of Obstetrics and Gynecology No. 3

Rostov-on-Don

michelson_aa@mail.ruhttps://orcid.org/0009-0003-9959-846XЗмиенкоВ. А.ZmienkoV. A.

Змиенко Вера Андреевна, аспирант кафедры акушерства и гинекологии №3

Ростов-на-Дону

Vera A. Zmienko, postgraduate student of the Department of Obstetrics and Gynecology No. 3

Rostov-on-Don

vesazonova@yandex.ruhttps://orcid.org/0009-0009-3668-3417СагамоновА. С.SagamonovA. S.

Сагамонов Артур Сергеевич, ординатор кафедры акушерства и гинекологии №3

Ростов-на-Дону

Artur S. Sagamonov, resident doctor of the Department of Obstetrics and Gynecology No. 3

Rostov-on-Don

a.sagamonov@gmail.ruhttps://orcid.org/0009-0000-6071-4396КормануковХ. Ю.KormanukovH. Yu.

Кормануков Хачерес Юрьевич, студент 5 курса лечебно-профилактического факультета

Ростов-на-Дону

Hacheres Yu. Kormanukov, 5th year student of the Faculty of Treatment and Prevention

Rostov-on-Don

po4tayashik715@yandex.ruРостовский государственный медицинский университетРоссияRostov State Medical UniversityRussian Federation2024130320241518293Copyright © Лебеденко Е.Ю., Михельсон А.А., Михельсон А.А., Змиенко В.А., Сагамонов А.С., Кормануков Х.Ю., 20242024Лебеденко Е.Ю., Михельсон А.А., Михельсон А.А., Змиенко В.А., Сагамонов А.С., Кормануков Х.Ю.Lebedenko E.Y., Mikhelson A.A., Mikhelson A.A., Zmienko V.A., Sagamonov A.S., Kormanukov H.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1892

Невынашивание беременности — не только медицинская, но и социальная проблема, носящая мультифакториальный характер, которая остается нерешаемой несмотря на постоянный поиск и применение новых диагностических и терапевтических стратегий. В представленном обзоре рассматриваются данные литературы о доказательных аспектах причин невынашивания беременности, а также методах, использование которых остается дискутабельным. Особое внимание уделяется иммунологическим основам формирования нормальной беременности, нарушение которых создает предпосылки для привычного выкидыша. Также в работе проанализированы современные данные о роли рецептивности эндометрия и вклада мужского фактора в проблему невынашивания, представлены перспективы дальнейших исследований по проблеме рецидивирующих репродуктивных потерь ранних сроков.

Recurrent pregnancy loss is not only a medical, but also a social problem of a multifactorial nature. This problem remains unsolvable despite the constant search and application of new diagnostic and therapeutic strategies. The presented review examines the literature data on evidence-based methods for diagnosing the causes of miscarriage, as well as methods whose use remains controversial. Special attention is paid to the immunological foundations of a normal pregnancy formation, the violation of which creates the prerequisites for a recurrent miscarriage. The paper also analyzes current data on the role of endometrial receptivity and the contribution of the male factor to the problem of miscarriage, and presents prospects for further research on the problem of recurrent pregnancy loss.

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The authors declare that there are no conflicts of interest present.